GWAS meta-analysis of 16 790 patients with Barrett’s oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level

Autor: Schröder, Julia, Chegwidden, Laura, Maj, Carlo, Gehlen, Jan, Speller, Jan, Böhmer, Anne C., Borisov, Oleg, Hess, Timo, Kreuser, Nicole, Venerito, Marino, Alakus, Hakan, May, Andrea, Gerges, Christian, Schmidt, Thomas, Thieme, Rene, Heider, Dominik, Hillmer, Axel M., Reingruber, Julian, Lyros, Orestis, Dietrich, Arne, Hoffmeister, Albrecht, Mehdorn, Matthias, Lordick, Florian, Stocker, Gertraud, Hohaus, Michael, Reim, Daniel, Kandler, Jennis, Müller, Michaela, Ebigbo, Alanna, Fuchs, Claudia, Bruns, Christiane J., Hölscher, Arnulf H., Lang, Hauke, Grimminger, Peter P., Dakkak, Dani, Vashist, Yogesh, May, Sandra, Görg, Siegfried, Franke, Andre, Ellinghaus, David, Galavotti, Sara, Veits, Lothar, Weismüller, Josef, Dommermuth, Jens, Benner, Udo, Rösch, Thomas, Messmann, Helmut, Schumacher, Brigitte, Neuhaus, Horst, Schmidt, Carsten, Wissinowski, Thaddäus T., Nöthen, Markus M., Dong, Jing, Ong, Jue-Sheng, Buas, Matthew F., Thrift, Aaron P., Vaughan, Thomas L., Tomlinson, Ian, Whiteman, David C., Fitzgerald, Rebecca Claire, Jankowski, Janusz, Vieth, Michael, Mayr, Andreas, Gharahkhani, Puya, MacGregor, Stuart, Gockel, Ines, Palles, Claire, Schumacher, Johannes, Prenen, Hans, Wellcome Trust Case Control Consortium 2 (WTCCC2), Esophageal Adenocarcinoma Genetics Consortium (EAGLE), Barrett's and Esophageal Adenocarcinoma Consortium (BEACON)

Publikováno v: Gut : the journal of the British Society for Gastroenterology

ObjectiveOesophageal cancer (EC) is the sixth leading cause of cancer-related deaths. Oesophageal adenocarcinoma (EA), with Barrett’s oesophagus (BE) as a precursor lesion, is the most prevalent EC subtype in the Western world. This study aims to c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8a9de8c99bbbe9155eb7d149c847b4
https://hdl.handle.net/10067/1893670151162165141

GWAS meta-analysis of 16 790 patients with Barrett’s oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level

Autor: Schro¨der, Julia, Chegwidden, Laura, Maj, Carlo, Gehlen, Jan, Speller, Jan, Bo¨hmer, Anne C, Borisov, Oleg, Hess, Timo, Kreuser, Nicole, Venerito, Marino, Alakus, Hakan, May, Andrea, Gerges, Christian, Schmidt, Thomas, Thieme, Rene, Heider, Dominik, Hillmer, Axel M, Reingruber, Julian, Lyros, Orestis, Dietrich, Arne, Hoffmeister, Albrecht, Mehdorn, Matthias, Lordick, Florian, Stocker, Gertraud, Hohaus, Michael, Reim, Daniel, Kandler, Jennis, Mu¨ller, Michaela, Ebigbo, Alanna, Fuchs, Claudia, Bruns, Christiane J, Ho¨lscher, Arnulf H, Lang, Hauke, Grimminger, Peter P, Dakkak, Dani, Vashist, Yogesh, May, Sandra, Go¨rg, Siegfried, Franke, Andre, Ellinghaus, David, Galavotti, Sara, Veits, Lothar, Weismu¨ller, Josef, Dommermuth, Jens, Benner, Udo, Ro¨sch, Thomas, Messmann, Helmut, Schumacher, Brigitte, Neuhaus, Horst, Schmidt, Carsten, Wissinowski, Thadda¨us T, No¨then, Markus M, Dong, Jing, Ong, Jue-Sheng, Buas, Matthew F, Thrift, Aaron P, Vaughan, Thomas L, Tomlinson, Ian, Whiteman, David C, Fitzgerald, Rebecca Claire, Jankowski, Janusz, Vieth, Michael, Mayr, Andreas, Gharahkhani, Puya, MacGregor, Stuart, Gockel, Ines, Palles, Claire, Schumacher, Johannes

Publikováno v: Gut; 2023, Vol. 72 Issue: 4 p612-623, 12p