Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload.

Autor: Vieira-Lara MA; Laboratory of Pediatrics, Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, Postbus 196, 9700, AD, Groningen, The Netherlands., Dommerholt MB; Laboratory of Pediatrics, Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, Postbus 196, 9700, AD, Groningen, The Netherlands., Zhang W; Laboratory of Pediatrics, Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, Postbus 196, 9700, AD, Groningen, The Netherlands.; Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands., Blankestijn M; Laboratory of Pediatrics, Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, Postbus 196, 9700, AD, Groningen, The Netherlands., Wolters JC; Laboratory of Pediatrics, Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, Postbus 196, 9700, AD, Groningen, The Netherlands.; Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands., Abegaz F; Laboratory of Pediatrics, Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, Postbus 196, 9700, AD, Groningen, The Netherlands., Gerding A; Laboratory of Pediatrics, Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, Postbus 196, 9700, AD, Groningen, The Netherlands.; Dutch Molecular Pathology Centre, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., van der Veen YT; Laboratory of Pediatrics, Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, Postbus 196, 9700, AD, Groningen, The Netherlands.; Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands., Thomas R; Dutch Molecular Pathology Centre, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., van Os RP; Central Animal Facility, Mouse Clinic for Cancer and Aging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Reijngoud DJ; Laboratory of Pediatrics, Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, Postbus 196, 9700, AD, Groningen, The Netherlands., Jonker JW; Laboratory of Pediatrics, Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, Postbus 196, 9700, AD, Groningen, The Netherlands., Kruit JK; Laboratory of Pediatrics, Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, Postbus 196, 9700, AD, Groningen, The Netherlands., Bakker BM; Laboratory of Pediatrics, Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, Postbus 196, 9700, AD, Groningen, The Netherlands. B.M.Bakker01@umcg.nl.

Publikováno v: BMC biology [BMC Biol] 2021 Jul 30; Vol. 19 (1), pp. 154. Date of Electronic Publication: 2021 Jul 30.

Short-term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue.

Autor: Dommerholt MB; Sections of Molecular Metabolism and Nutrition, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Blankestijn M; Sections of Molecular Metabolism and Nutrition, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Vieira-Lara MA; Sections of Systems Medicine of Metabolism and Signaling, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., van Dijk TH; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, the Netherlands., Wolters H; Sections of Molecular Metabolism and Nutrition, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Koster MH; Sections of Molecular Metabolism and Nutrition, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Gerding A; Sections of Systems Medicine of Metabolism and Signaling, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, the Netherlands., van Os RP; Mouse Clinic for Cancer and Aging, Central Animal Facility, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Bloks VW; Sections of Molecular Metabolism and Nutrition, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Bakker BM; Sections of Systems Medicine of Metabolism and Signaling, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Kruit JK; Sections of Molecular Metabolism and Nutrition, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Jonker JW; Sections of Molecular Metabolism and Nutrition, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Publikováno v: The FEBS journal [FEBS J] 2021 Apr; Vol. 288 (7), pp. 2257-2277. Date of Electronic Publication: 2020 Nov 09.

Fibroblast growth factors in control of lipid metabolism: from biological function to clinical application.

Autor: Struik D; Department of Pediatrics, Section of Molecular Metabolism and Nutrition, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Dommerholt MB, Jonker JW

Publikováno v: Current opinion in lipidology [Curr Opin Lipidol] 2019 Jun; Vol. 30 (3), pp. 235-243.

NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation.

Autor: Riedlinger T; Institute of Biochemistry, Medical Faculty, Friedrichstrasse 24, Justus-Liebig-University, D-35392 Giessen, Germany., Dommerholt MB; Section of Molecular Metabolism and Nutrition, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713, AV, Groningen, The Netherlands., Wijshake T; Section of Molecular Genetics, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713, AV, Groningen, The Netherlands; Departments of Pediatrics and Adolescent Medicine, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN, USA., Kruit JK; Section of Molecular Metabolism and Nutrition, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713, AV, Groningen, The Netherlands., Huijkman N; Section of Molecular Genetics, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713, AV, Groningen, The Netherlands., Dekker D; Section of Molecular Genetics, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713, AV, Groningen, The Netherlands., Koster M; Section of Molecular Genetics, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713, AV, Groningen, The Netherlands., Kloosterhuis N; Section of Molecular Genetics, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713, AV, Groningen, The Netherlands., Koonen DPY; Section of Molecular Genetics, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713, AV, Groningen, The Netherlands., de Bruin A; Section of Molecular Genetics, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713, AV, Groningen, The Netherlands; Dutch Molecular Pathology Center, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Baker D; Departments of Pediatrics and Adolescent Medicine, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN, USA., Hofker MH; Section of Molecular Genetics, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713, AV, Groningen, The Netherlands., van Deursen J; Departments of Pediatrics and Adolescent Medicine, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN, USA., Jonker JW; Section of Molecular Metabolism and Nutrition, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713, AV, Groningen, The Netherlands., Schmitz ML; Institute of Biochemistry, Medical Faculty, Friedrichstrasse 24, Justus-Liebig-University, D-35392 Giessen, Germany., van de Sluis B; Section of Molecular Genetics, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713, AV, Groningen, The Netherlands. Electronic address: a.j.a.van.de.sluis@umcg.nl.

Publikováno v: Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2017 Oct; Vol. 1864 (10), pp. 1785-1798. Date of Electronic Publication: 2017 Jul 16.