Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Domiziana Masci"'
Publikováno v:
Molecules, Vol 29, Iss 19, p 4524 (2024)
CBP and p300 are versatile transcriptional co-activators that play essential roles in regulating a wide range of signaling pathways, including Wnt/β-catenin, p53, and HIF-1α. These co-activators influence various cellular processes such as prolifer
Externí odkaz:
https://doaj.org/article/becd2ba5fd5d46d3829664884ee879a8
Autor:
Akram Abd El-Haleem, Usama Ammar, Domiziana Masci, Sohair El-Ansary, Doaa Abdel Rahman, Fatma Abou-Elazm, Nehad El-Dydamony
Publikováno v:
Pharmaceuticals, Vol 17, Iss 9, p 1197 (2024)
Bacterial DNA gyrase is considered one of the validated targets for antibacterial drug discovery. Benzopyrones have been reported as promising derivatives that inhibit bacterial DNA gyrase B through competitive binding into the ATP binding site of th
Externí odkaz:
https://doaj.org/article/d7748974fece4ca48486d74412e6db9e
Autor:
Anna Percio, Michela Cicchinelli, Domiziana Masci, Mariagrazia Summo, Andrea Urbani, Viviana Greco
Publikováno v:
Antioxidants, Vol 13, Iss 8, p 883 (2024)
Redox dysregulation, an imbalance between oxidants and antioxidants, is crucial in the pathogenesis of various neurodegenerative diseases. Within this context, the “redoxome” encompasses the network of redox molecules collaborating to maintain ce
Externí odkaz:
https://doaj.org/article/83dc999d66fd4caea5ad8d9a94c53c7c
Publikováno v:
Molecules, Vol 29, Iss 9, p 2110 (2024)
Alterations in cellular metabolism, such as dysregulation in glycolysis, lipid metabolism, and glutaminolysis in response to hypoxic and low-nutrient conditions within the tumor microenvironment, are well-recognized hallmarks of cancer. Therefore, un
Externí odkaz:
https://doaj.org/article/ac60eefba1d04b8ca683b589b74619eb
Autor:
Lorenza Marinaccio, Gokhan Zengin, Stefano Pieretti, Paola Minosi, Edina Szucs, Sandor Benyhe, Ettore Novellino, Domiziana Masci, Azzurra Stefanucci, Adriano Mollica
Publikováno v:
Food Chemistry: X, Vol 18, Iss , Pp 100640- (2023)
Rubiscolin-6 (amino acid sequence: YPLDLF) is a selective δ-opioid receptor peptide isolated from spinach Rubisco. Its synthetic analogue, peptide YPMDIV is the most potent described so far for its increased opioid activity, thus in this work it was
Externí odkaz:
https://doaj.org/article/8ae8bcac785b43ffa3acc6337d66acbf
Autor:
Domiziana Masci, Chiara Naro, Michela Puxeddu, Andrea Urbani, Claudio Sette, Giuseppe La Regina, Romano Silvestri
Publikováno v:
Molecules, Vol 28, Iss 22, p 7513 (2023)
Triple-negative breast cancer (TNBC) is one of the most heterogeneous and aggressive breast cancer subtypes with a high risk of death on recurrence. To date, TNBC is very difficult to treat due to the lack of an effective targeted therapy. However, r
Externí odkaz:
https://doaj.org/article/b166d36cc2c644eaaf2b9adfc9fc4897
Autor:
Francesco Cairone, Dario Allevi, Stefania Cesa, Giancarlo Fabrizi, Antonella Goggiamani, Domiziana Masci, Antonia Iazzetti
Publikováno v:
Foods, Vol 12, Iss 17, p 3286 (2023)
Rapeseed meal (RSM) is a by-product of rapeseed oil extraction and is a rich source of bioactive compounds, including proteins and antioxidants. This study compared two methods for extracting antioxidants from RSM: conventional ethanol Soxhlet extrac
Externí odkaz:
https://doaj.org/article/4d11b8a26e4c4592833a701fe034cc5e
Publikováno v:
Molecules, Vol 27, Iss 22, p 7735 (2022)
Aberrant accumulation of β-catenin in the cell nucleus as a result of deregulation of the Wnt/β-catenin pathway is found in various types of cancer. Direct β-catenin targeting agents are being researched despite obstacles; however, specific β-cat
Externí odkaz:
https://doaj.org/article/1b39d13dd54f47c4b58c881d37a6deb7
Autor:
Sveva Pelliccia, Yu-Hsuan Wu, Antonio Coluccia, Giuseppe La Regina, Chin-Kai Tseng, Valeria Famiglini, Domiziana Masci, John Hiscott, Jin-Ching Lee, Romano Silvestri
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 1091-1101 (2017)
Dengue virus (DENV) is the leading mosquito-transmitted viral infection in the world. With more than 390 million new infections annually, and up to 1 million clinical cases with severe disease manifestations, there continues to be a need to develop n
Externí odkaz:
https://doaj.org/article/bf23c1b2976a4e1abd0b5502b69c15cf
Autor:
Azzurra Stefanucci, Alice Della Valle, Giuseppe Scioli, Lorenza Marinaccio, Stefano Pieretti, Paola Minosi, Edina Szucs, Sandor Benyhe, Domiziana Masci, Parthasaradhireddy Tanguturi, Kerry Chou, Deborah Barlow, Karen Houseknecht, John M. Streicher, Adriano Mollica
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1707-1714