Výsledky vyhledávání - "Dominique Y Pifat"

Ensuring the Biologic Safety of Plasma-Derived Therapeutic Proteins

Autor: Todd M. Gierman, Dominique Y. Pifat, Steve R. Petteway, Kang Cai, Joann Hotta, Christopher J. Stenland, Douglas C. Lee

Publikováno v: Biodrugs

Human plasma-derived proteins, such as immunoglobulins, coagulation factors, alpha1-antitrypsin, fibrin sealants, and albumin, are widely used as therapeutics for many serious and life-threatening medical conditions. The human origin of these protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67c10285a78e9c16373da7edea6b802
https://doi.org/10.2165/00063030-200519020-00002

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Anthrax vaccine: immunogenicity and safety of a dose-reduction, route-change comparison study in humans

Autor: Gerald W. Parker, Robert Myers, Phillip R. Pittman, Dominique Y Pifat, Arthur M. Friedlander, Paul H. Gibbs, Gina Kim-Ahn, Kevin Coonan, Steve Little, Judith G Pace-Templeton

Publikováno v: Vaccine. 20:1412-1420

Anthrax vaccine adsorbed (AVA), an effective countermeasure against anthrax, is administered as six subcutaneous (SQ) doses over 18 months. To optimize the vaccination schedule and route of administration, we performed a prospective pilot study compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b35481a35789ad06104f94d4824a24
https://doi.org/10.1016/s0264-410x(01)00462-5

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Role of hepatocytes and Kupffer cells in age-dependent murine hepatitis caused by a phlebovirus, Punta Toro

Autor: Patricia S. Latham, Susan B. Sepelak, Jonathan F. Smith, Dominique Y. Pifat

Publikováno v: Journal of Medical Virology. 33:10-18

Punta Toro virus (PTV) infection of C57BL/6 mice results in fulminant hepatic necrosis and death in 3-week-old susceptible mice, but survival with minimal hepatocellular necrosis in 8-week-old resistant mice. Susceptibility in 3-week-old mice is asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9434d2dac627b7a9c1da7cb90702cfae
https://doi.org/10.1002/jmv.1890330104

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Effects of ribamidine, a 3-carboxamidine derivative of ribavirin, on experimentally induced Phlebovirus infections

Autor: Robert W. Sidwell, John H. Huffman, Dale L. Barnard, Dominique Y. Pifat

Publikováno v: Antiviral Research. 10:193-207

Ribamidine (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine) was inhibitory in rhesus monkey kidney (LLC-MK2 derivative) cells to Adames and Balliet strains of Punta Toro virus (PTV), a Phlebovirus related to Rift Valley fever and sandfly fever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea019dbda9f3e121977bf4c2a8a7ae8
https://doi.org/10.1016/0166-3542(88)90031-9

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Punta Toro virus infection of C57BL/6J mice: a model for phlebovirus-induced disease

Autor: Dominique Y. Pifat, Jonathan F. Smith

Publikováno v: Microbial Pathogenesis. 3:409-422

Punta Toro virus infections of inbred strains of mice have been characterized and evaluated as a model in which to study various aspects of the host response to phlebovirus infections and the requirements for protective immunity. The Adames strain of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f61732fc5ec860758ea58b4272d315
https://doi.org/10.1016/0882-4010(87)90011-8

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Antigenic analysis of Punta Toro Virus and identification of protective determinants with monoclonal antibodies

Autor: Jonathan F. Smith, Dominique Y. Pifat, Mark C. Osterling

Publikováno v: Virology. 167:442-450

Hybridomas producing monoclonal antibodies to the three major structural proteins of Punta Toro virus (PTV) were established by fusion of spleen cells with Sp2/0-Ag-14 mouse plasmacytoma cells. Thirty-six independently derived monoclonal antibodies w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a450879bcf834290a820a230500224ef
https://doi.org/10.1016/0042-6822(88)90106-7

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Junin virus monoclonal antibodies: characterization and cross-reactivity with other arenaviruses

Autor: Clarence J. Peters, Dominique Y. Pifat, Michael P. Kiley, Joseph B. McCormick, Anthony Sanchez, Richard H. Kenyon

Publikováno v: The Journal of general virology. 70

Twenty-one monoclonal antibodies reactive with Junin virus structural proteins were produced and characterized. Using radioimmunoprecipitation and Western blot assays, 13 were found to react with the nucleoprotein, seven with the surface glycoprotein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d5212853c7ce610d00ac3a2096c753
https://pubmed.ncbi.nlm.nih.gov/2471803

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In Vitro and in Vivo Phlebovirus Inhibition by Nucleosides Related to Ribavirin

Autor: Ganapathi R. Revankar, Robert W. Sidwell, John H. Huffman, Roland K. Robins, Dominique Y. Pifat

Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 8:1159-1160

Eleven compounds were compared to ribavirin for their in vitro and in vivo inhibition of Punta Toro virus (PTV), a phlebovirus in the Bunyaviridae virus family.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e75de66238f279adbace924ad8cfab3
https://doi.org/10.1080/07328318908054318

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