Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Dominique T. Brandt"'
Autor:
Chen Jiang, Ahsan Javed, Laura Kaiser, Michele M. Nava, Rui Xu, Dominique T. Brandt, Dandan Zhao, Benjamin Mayer, Javier Fernández-Baldovinos, Luping Zhou, Carsten Höß, Kovilen Sawmynaden, Arkadiusz Oleksy, David Matthews, Lee S. Weinstein, Heidi Hahn, Hermann-Josef Gröne, Peter L. Graumann, Carien M. Niessen, Stefan Offermanns, Sara A. Wickström, Thomas Worzfeld
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
It is unclear how epithelial tissues adjust cell division rates to cell density. Here, the authors show that Plexin-B1 and Plexin-B2 sense mechanical compression (crowding) of epidermal stem cells, resulting in inactivation of YAP and suppression of
Externí odkaz:
https://doaj.org/article/c31e77abae1d4cc9839c925693d0c2fb
Autor:
Silke Reinartz, Sonja Lieber, Jelena Pesek, Dominique T. Brandt, Alina Asafova, Florian Finkernagel, Bernard Watzer, Wolfgang Andreas Nockher, Andrea Nist, Thorsten Stiewe, Julia M. Jansen, Uwe Wagner, Anne Konzer, Johannes Graumann, Robert Grosse, Thomas Worzfeld, Sabine Müller‐Brüsselbach, Rolf Müller
Publikováno v:
Molecular Oncology, Vol 13, Iss 2, Pp 185-201 (2019)
The peritoneal fluid of ovarian carcinoma patients promotes cancer cell invasion and metastatic spread with lysophosphatidic acid (LPA) as a potentially crucial mediator. However, the origin of LPA in ascites and the clinical relevance of individual
Externí odkaz:
https://doaj.org/article/e7b07ecf563740a58d0b49e54170b0d7
Autor:
Rui Xu, Carsten Höß, Jakub M. Swiercz, Dominique T. Brandt, Veronika Lutz, Natalia Petersen, Rui Li, Dandan Zhao, Arkadiusz Oleksy, Tilbe Creigh-Pulatmen, Martina Trokter, Marina Fedorova, Ann Atzberger, Rune B. Strandby, August A. Olsen, Michael P. Achiam, David Matthews, Magdalena Huber, Hermann-Josef Gröne, Stefan Offermanns, Thomas Worzfeld
Publikováno v:
Science translational medicine. 14(654)
Peptic ulcer disease is a frequent clinical problem with potentially serious complications such as bleeding or perforation. A decisive factor in the pathogenesis of peptic ulcers is gastric acid, the secretion of which is controlled by the hormone ga
Autor:
Annely Brandt, Matthias Schott, Maximilian Sandmann, Stephanie Krueger, Andreas Vilcinskas, Dominique T. Brandt, Marina D. Meixner, Gerrit Eichner, Rolf-Alexander Düring, Gertrud E. Morlock, James E. Cresswell, Matthias A. Becher, Ralph Büchler, Rayko Halitschke
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Sublethal doses of pesticides affect individual honeybees, but colony-level effects are less well understood and it is unclear how the two levels integrate. We studied the effect of the neonicotinoid pesticide clothianidin at field realistic concentr
Autor:
Florian Finkernagel, Julia M. Jansen, Sabine Müller-Brüsselbach, Silke Reinartz, Johannes Graumann, Sonja Lieber, Alina Asafova, Anne Konzer, Thomas Worzfeld, Jelena Pesek, Uwe Wagner, Dominique T. Brandt, Wolfgang Andreas Nockher, Bernard Watzer, Andrea Nist, Robert Grosse, Thorsten Stiewe, Rolf Müller
Publikováno v:
Molecular Oncology, Vol 13, Iss 2, Pp 185-201 (2019)
Molecular Oncology
Molecular Oncology
The peritoneal fluid of ovarian carcinoma patients promotes cancer cell invasion and metastatic spread with lysophosphatidic acid (LPA) as a potentially crucial mediator. However, the origin of LPA in ascites and the clinical relevance of individual
Autor:
Hermann-Josef Groene, Dominique T. Brandt, Stefan Offermanns, Chen Jiang, Lee S. Weinstein, Arkadiusz Oleksy, David A. Matthews, Javier Fernandez-Baldovinos, Carsten Hoess, Carien M. Niessen, Laura Kaiser, Sara A. Wickström, Ahsan Javed, Thomas Worzfeld, Kovilen Sawmynaden, Luping Zhou, Dandan Zhao, Michele M. Nava
The precise spatiotemporal control of cell proliferation is key to the morphogenesis of epithelial tissues. Epithelial cell divisions lead to tissue crowding and local changes in force distribution, which in turn suppress the rate of cell divisions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980562200bf0b0fd3f38d22aad2a3634
https://doi.org/10.1101/2020.04.30.070359
https://doi.org/10.1101/2020.04.30.070359
Autor:
Jannik Winkelmeier, David Virant, Julian Knerr, Ulrike Endesfelder, Carsten Schwan, Robert Grosse, Sylvia Krippner, Dominique T. Brandt
Publikováno v:
EMBO Reports
The actin cytoskeleton operates in a multitude of cellular processes including cell shape and migration, mechanoregulation, and membrane or organelle dynamics. However, its filamentous properties and functions inside the mammalian cell nucleus are le
Autor:
Robert Grosse, Thorsten Stiewe, Michael Wanzel, Udo Siebolts, Fotini Vogiatzi, Roland Moll, Joël P. Charles, Marco Mernberger, Eva Johanna Kantelhardt, Jean Schneikert, Ariane Rath, Jeannette Fuchs, Ralf Jacob, Dominique T. Brandt, Frank Bartel, Andrea Nist, Evangelos Pavlakis, Katharina Grikscheit, Oleg Timofeev
Mutations in the p53 tumor suppressor gene are the most frequent genetic alteration in cancer and are often associated with progression from benign to invasive stages with metastatic potential. Mutations inactivate tumor suppression by p53, and some
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94753e79dcdb07a06ce6a02483adc51c
https://europepmc.org/articles/PMC5206569/
https://europepmc.org/articles/PMC5206569/
Publikováno v:
Scopus-Elsevier
Transcriptional signaling networks are orchestrated and fine-tuned through multiple interactions of transcription factors with subsets of cofactors thereby assembling multiprotein complexes to negatively or positively balance transcriptional output.
SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of β1-integrin
Autor:
Johanna Ivaska, Christian Baarlink, Peter Nollau, Dominique T. Brandt, Elisabeth Kremmer, Thomas M. Kitzing, Robert Grosse
Publikováno v:
Brandt, D T, Baarlink, C, Kitzing, T M, Kremmer, E, Ivaska, J, Nollau, P & Grosse, R 2009, ' SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of β 1-integrin ', Nature Cell Biology, vol. 11, pp. 557-568 . https://doi.org/10.1038/ncb1862
Gene expression reprogramming governs cellular processes such as proliferation, differentiation and cell migration through the complex and tightly regulated control of transcriptional cofactors that exist in multiprotein complexes. Here we describe S