Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Dominique P. V. de Kleijn"'
Autor:
Raisa Kraaijvanger, Montse Janssen Bonás, Jan C. Grutters, Ioanna Paspali, Marcel Veltkamp, Dominique P. V. de Kleijn, Coline H. M. van Moorsel
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Sarcoidosis is a systemic granulomatous disease of unknown etiology primarily affecting the lungs. Treatment is needed when disease symptoms worsen and organ function deteriorates. In pulmonary sarcoidosis, prednisone and methotre
Externí odkaz:
https://doaj.org/article/3fa121e54f9e4498b2f8d377a802a446
Autor:
Joost M. Mekke, Tim R. Sakkers, Maarten C. Verwer, Noortje A. M. van den Dungen, Yipei Song, Clint L. Miller, Aloke V. Finn, Gerard Pasterkamp, Michal Mokry, Hester M. den Ruijter, Aryan Vink, Dominique P. V. de Kleijn, Gert J. de Borst, Saskia Haitjema, Sander W. van der Laan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The accumulation of erythrocyte membranes within an atherosclerotic plaque may contribute to the deposition of free cholesterol and thereby the enlargement of the necrotic core. Erythrocyte membranes can be visualized and quantified in the p
Externí odkaz:
https://doaj.org/article/05972807f3624398a1febbfc56363a26
Autor:
Barend M. Mol, Maarten C. Verwer, Rob Fijnheer, Jasper Florie, Oscar A. Groot, Falco Hietbrink, Mathilde Nijkeuter, Evert-Jan P. A. Vonken, Vincent van Weel, Dominique P. V. de Kleijn, Gert J. de Borst
Publikováno v:
PLoS ONE, Vol 19, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/9e3e6a559b1141199f20a8be442c369c
Autor:
Michele F. Buono, Ernest Diez Benavente, Mark Daniels, Barend M. Mol, Joost M. Mekke, Gert J. de Borst, Dominique P. V. de Kleijn, Sander W. van der Laan, Gerard Pasterkamp, Charlotte Onland-Moret, Michal Mokry, Hester M. den Ruijter
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Background and aim Sex differences in atherosclerosis have been described with female plaques being mostly perceived as stable and fibrous. Sex-specific mechanisms such as mosaic loss of the Y chromosome in men have been linked to cardiovasc
Externí odkaz:
https://doaj.org/article/4e4428b9f36047999a8fccac55639989
Autor:
Michele F. Buono, Ernest Diez Benavente, Lotte Slenders, Daisey Methorst, Daniëlle Tessels, Eloi Mili, Roxy Finger, Daniek Kapteijn, Mark Daniels, Noortje A. M. van den Dungen, Jorg J. A. Calis, Barend M. Mol, Gert J. de Borst, Dominique P. V. de Kleijn, Gerard Pasterkamp, Hester M. den Ruijter, Michal Mokry
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 21 (2023)
Background Plaque myofibroblasts are critical players in the initiation and advancement of atherosclerotic disease. They are involved in the production of extracellular matrix, the formation of the fibrous cap, and the underlying lipidic core via mod
Externí odkaz:
https://doaj.org/article/cd25f14d033d48ac9391413aa12d5e81
Autor:
Yipei Song, Francesco Cisternino, Joost M. Mekke, Gert J. de Borst, Dominique P. V. de Kleijn, Gerard Pasterkamp, Aryan Vink, Craig A. Glastonbury, Sander W. van der Laan, Clint L. Miller
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Tissue segmentation of histology whole-slide images (WSI) remains a critical task in automated digital pathology workflows for both accurate disease diagnosis and deep phenotyping for research purposes. This is especially challenging when th
Externí odkaz:
https://doaj.org/article/7e57fd728df44a249fe5898c3e98bc0d
Autor:
Maarten C. Verwer, Joost Mekke, Nathalie Timmerman, Farahnaz Waissi, Arjan Boltjes, Gerard Pasterkamp, Gert J. de Borst, Dominique P. V. de Kleijn
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Extracellular vesicles (EV) are a novel biomarker source for diagnosis and prognosis of cardiovascular disease. A protein comparison of plasma EVs in relation to blood plasma and atherosclerotic plaque has not been performed but would provid
Externí odkaz:
https://doaj.org/article/a86e4c0f8a3f40668db8795be1b148a9
Autor:
Nathalie Timmerman, Farahnaz Waissi, Mirthe Dekker, Gert J. de Borst, Joelle van Bennekom, Robbert J. de Winter, Mika Hilvo, Antti Jylhä, Gerard Pasterkamp, Dominique P. V. de Kleijn, Reijo Laaksonen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Ceramides and phosphatidylcholines (PCs) are bioactive lipids and lipid bilayer membrane components. Distinct ceramides/PCs (ratios) predict cardiovascular outcome in patients with coronary artery disease. Extracellular vesicles (EVs) are pr
Externí odkaz:
https://doaj.org/article/dc6070f4c914474b9e5d7eaa5082b59a
Autor:
Cho Yeow Koh, Norrapat Shih, Christina Y. C. Yip, Aaron Wei Liang Li, Weiming Chen, Fathiah S. Amran, Esther Jia En Leong, Janaki Krishnamoorthy Iyer, Grace Croft, Muhammad Ibrahim Bin Mazlan, Yen-Lin Chee, Eng-Soo Yap, Dougald M. Monroe, Maureane Hoffman, Richard C. Becker, Dominique P. V. de Kleijn, Vaishali Verma, Amita Gupta, Vijay K. Chaudhary, A. Mark Richards, R. Manjunatha Kini, Mark Y. Chan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Bleeding complications limits the use of effective antithrombotics therapeutics. Here, the authors developed next-generation direct thrombin inhibitors with low bleeding risks as safe peri-percutaneous coronary intervention anticoagulants when used i
Externí odkaz:
https://doaj.org/article/cad6e99b695d4c66a9002c62027f15b1
Autor:
Mirthe Dekker, Farahnaz Waissi, Max J. M. Silvis, Joelle V. Bennekom, Arjan H. Schoneveld, Robbert J. de Winter, Ivana Isgum, Nikolas Lessmann, Birgitta K. Velthuis, Gerard Pasterkamp, Arend Mosterd, Leo Timmers, Dominique P. V. de Kleijn
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Plasma osteoprotegerin (OPG) and vascular smooth muscle cell (VSMC) derived extracellular vesicles (EVs) are important regulators in the process of vascular calcification (VC). In population studies, high levels of OPG are associated with ev
Externí odkaz:
https://doaj.org/article/9765ad5d9fff425aa1f3521772d3c650