Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Dominique N Soroka"'
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54677 (2013)
Our previous study found that [6]-shogaol, a major bioactive component in ginger, is extensively metabolized in cancer cells and in mice. It is unclear whether these metabolites retain bioactivity. The aim of the current study is to synthesize the ma
Externí odkaz:
https://doaj.org/article/bda964c101ea497d91c429bea227fc95
Publikováno v:
Journal of agricultural and food chemistry. 66(45)
Colon cancer, one of the leading causes of cancer-associated deaths, is the target of choice for nutrition-based-prevention approaches because of the direct and early contact between the active compounds and the cancerous tissues. We previously repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dabdf2047fc5d5d76c3f1507c4e6893
https://pubmed.ncbi.nlm.nih.gov/30354111
https://pubmed.ncbi.nlm.nih.gov/30354111
Autor:
Edward E. Schmidt, Feng Yan, Xiaoxin Chen, Michael B. Major, Junsheng Fu, Justin R. Prigge, Shengmin Sang, Dominique N. Soroka, Huadong Chen, Hao Chen, Yuhui Hu
Publikováno v:
Chemical Research in Toxicology
In this study, we identified Nrf2 as a molecular target of [6]-shogaol (6S), a bioactive compound isolated from ginger, in colon epithelial cells in vitro and in vivo. Following 6S treatment of HCT-116 cells, the intracellular GSH/GSSG ratio was init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a193eb77afd03de2afc542b5f1a10942
http://europepmc.org/articles/PMC4176387
http://europepmc.org/articles/PMC4176387
Publikováno v:
Journal of Agricultural and Food Chemistry
Dietary chemoprevention of cancer offers the possibility to suppress or inhibit cancer growth before it develops into more advanced and lethal stages. To this end, identification of novel compounds and their mechanisms of action is constantly needed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcfe1d7a7b80dc37f9c0126108e43216
https://doi.org/10.1021/jf405573e
https://doi.org/10.1021/jf405573e
Autor:
Huadong Chen, TinChung Leung, Dominique N. Soroka, Karine F. Ferri-Lagneau, Shengmin Sang, Jamil Haider
Publikováno v:
Journal of Agricultural and Food Chemistry. 61:5353-5360
Gingerols are a series of major constituents in fresh ginger with the most abundant being [6]-, [8]-, and [10]-gingerols (6G, 8G, and 10G). We previously found that ginger extract and its purified components, especially 10G, potentially stimulate bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76f62618fe9f600a3c0caf324b59923
https://doi.org/10.1021/jf401501s
https://doi.org/10.1021/jf401501s
Publikováno v:
Molecular Nutrition & Food Research. 57:447-458
Scope Shogaols, a series of major constituents in dried ginger with the most abundant being [6]-, [8]-, and [10]-shogaols, show much higher anticancer potencies than gingerols. Previously, we reported the mercapturic acid pathway as a major metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485affdb9c7028fa609a021ce010c047
https://doi.org/10.1002/mnfr.201200679
https://doi.org/10.1002/mnfr.201200679
Publikováno v:
Molecular Nutrition & Food Research. 57:865-876
Scope There are limited data on the metabolism of [6]-shogaol (6S), a major bioactive component of ginger. This study demonstrates metabolism of 6S in liver microsomes from mouse, rat, dog, monkey, and human. Methods and results The in vitro metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734d49358a49d0e46c7ac11a29493da8
https://doi.org/10.1002/mnfr.201200708
https://doi.org/10.1002/mnfr.201200708
Publikováno v:
Journal of Agricultural and Food Chemistry. 61:866-874
Sphingolipids are known to have diverse properties and physiological functions. These distinctive lipids have been identified in wheat bran, a food well-known for its chemopreventive activity. However, the complete profile of sphingolipids in wheat b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc871ef090c720fa492ad4470f5ce9bb
https://doi.org/10.1021/jf3047863
https://doi.org/10.1021/jf3047863
Autor:
Junsheng Fu, Yuhuii Hu, Dominique N. Soroka, Yingdong Zhu, Xiaoxin Luke Chen, Shengmin Sang, Kelly Shurlknight
Publikováno v:
Journal of medicinal chemistry. 58(16)
Regular aspirin use has been convincingly shown to reduce the risk of colorectal cancer. However, long-term use of aspirin leads to gastrotoxicity. Herein, we designed and synthesized a novel class of resveratrol-based aspirin prodrugs to simultaneou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7847ad3857cd263691330cafff3cbf
https://pubmed.ncbi.nlm.nih.gov/26204233
https://pubmed.ncbi.nlm.nih.gov/26204233
Publikováno v:
Journal of agricultural and food chemistry. 63(8)
Consumption of whole grains has been reported to be associated with a lower risk of colorectal cancer. Recent studies illustrated that phytochemicals in wheat bran (WB) may protect against colorectal cancer. There is a growing interest in the phytost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9e8a14978234da2adc4de3c2bb7dad
https://pubmed.ncbi.nlm.nih.gov/25658220
https://pubmed.ncbi.nlm.nih.gov/25658220