Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism

Autor: Haico van Attikum, Kirsten van Harten, Iris J. E. Stulemeijer, Trey Ideker, Rohith Srivas, Fred van Leeuwen, Su Ming Sun, Farid El Oualid, Hanneke Vlaming, Tineke L. Lenstra, Dominique Morais, Tibor van Welsem, Huib Ovaa, Frank C. P. Holstege, Tessy Korthout, Reggy Ekkebus, Deepani W. Poramba-Liyanage, Thom M Molenaar

Publikováno v: Nucleic Acids Research
Nucleic acids research, 46(21), 11251-11261. Oxford University Press
Nucleic Acids Research, 46(21), 11251-11261

The histone methyltransferase Dot1 is conserved from yeast to human and methylates lysine 79 of histone H3 (H3K79) on the core of the nucleosome. H3K79 methylation by Dot1 affects gene expression and the response to DNA damage, and is enhanced by mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca968c97e6ee05a0158c1e40575b5132
https://hdl.handle.net/1887/86410