The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier

Autor: Magdalena Kurtyka, Frank Wessely, Sarah Bau, Eseoghene Ifie, Liqun He, Nienke M. de Wit, Alberte Bay Villekjær Pedersen, Maximilian Keller, Caleb Webber, Helga E. de Vries, Olaf Ansorge, Christer Betsholtz, Marijke De Bock, Catarina Chaves, Birger Brodin, Morten S. Nielsen, Winfried Neuhaus, Robert D. Bell, Tamás Letoha, Axel H. Meyer, Germán Leparc, Martin Lenter, Dominique Lesuisse, Zameel M. Cader, Stephen T. Buckley, Irena Loryan, Claus U. Pietrzik

Publikováno v: European Journal of Cell Biology, Vol 103, Iss 2, Pp 151406- (2024)

Despite extensive research, targeted delivery of substances to the brain still poses a great challenge due to the selectivity of the blood-brain barrier (BBB). Most molecules require either carrier- or receptor-mediated transport systems to reach the

Externí odkaz: https://doaj.org/article/24cf1f3bfe6c41b79a62e5eaa26fce38

Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model

Autor: Tuan-Minh Do, Cécile Capdevila, Laurent Pradier, Véronique Blanchard, Mati Lopez-Grancha, Nathalie Schussler, Anke Steinmetz, Jochen Beninga, Denis Boulay, Philippe Dugay, Patrick Verdier, Nadine Aubin, Gihad Dargazanli, Catarina Chaves, Elisabeth Genet, Yves Lossouarn, Christophe Loux, François Michoux, Nicolas Moindrot, Franck Chanut, Thierry Gury, Stéphanie Eyquem, Delphine Valente, Olivier Bergis, Ercole Rao, Dominique Lesuisse

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 58-77 (2020)

Most antibodies display very low brain exposure due to the blood-brain barrier (BBB) preventing their entry into brain parenchyma. Transferrin receptor (TfR) has been used previously to ferry antibodies to the brain by using different formats of bisp

Externí odkaz: https://doaj.org/article/83381acf39a84e849321af0a96b558c0

Data on synthesis, ADME and pharmacological properties and early safety pharmacology evaluation of a series of novel NURR1/NOT agonist potentially useful for the treatment of Parkinson's disease

Autor: André Malanda, Pierre-Yves Abécassis, Pascal Barnéoud, Pascale Brunel, Véronique Taupin, Xavier Vigé, Dominique Lesuisse

Publikováno v: Data in Brief, Vol 27, Iss , Pp - (2019)

This article describes the chemical synthesis, ADME and pharmacological properties and early safety pharmacology evaluation of a series of novel Nurr1/NOT agonist. It is meant as a support to an article recently published in Bioorganic and Medicinal

Externí odkaz: https://doaj.org/article/05051d3cfbe34e0dbf7765b754751143

Brain Delivery of Single-Domain Antibodies: A Focus on VHH and VNAR

Autor: Elodie Pothin, Dominique Lesuisse, Pierre Lafaye

Publikováno v: Pharmaceutics, Vol 12, Iss 10, p 937 (2020)

Passive immunotherapy, i.e., treatment with therapeutic antibodies, has been increasingly used over the last decade in several diseases such as cancers or inflammation. However, these proteins have some limitations that single-domain antibodies could

Externí odkaz: https://doaj.org/article/5926b14a6803488c98a8b0fb50ea8de4

Peptidomics of Haemonchus contortus

Autor: John Harrington, Camille Allain, Armelle Buzy, Aaron G. Maule, David F. Bruhn, Jean-Claude Guillemot, Dominique Lesuisse, Vincent Mikol

Publikováno v: ACS Omega, Vol 6, Iss 15, Pp 10288-10305 (2021)
Buzy, A, Allain, C, Harrington, J, Lesuisse, D, Mikol, V, Bruhn, D F, Maule, A G & Guillemot, J-C 2021, ' Peptidomics of Haemonchus contortus ', ACS Omega, vol. 6, no. 15, pp. 10288-10305 . https://doi.org/10.1021/acsomega.1c00650

The nematode Haemonchus contortus (the barber's pole worm) is an endoparasite infecting wild and domesticated ruminants worldwide. Widespread anthelmintic resistance of H. contortus requires alternative strategies to control this parasite. Neuropepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259d3acb28da7e00424497aaf2092b75
https://doaj.org/article/0d3dfcf32203481a995ff60786dae934