Zobrazeno 1 - 10
of 368
pro vyhledávání: '"Dominique Langin"'
Autor:
Lenka Rossmeislová, Eva Krauzová, Michal Koc, Marek Wilhelm, Viktor Šebo, Zuzana Varaliová, Veronika Šrámková, Moniek Schouten, Petr Šedivý, Petr Tůma, Jan Kovář, Dominique Langin, Jan Gojda, Michaela Šiklová
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e37875- (2024)
Fasting induces significant shifts in substrate utilization with signs of acute insulin resistance (IR), while obesity is associated with chronic IR. Nonetheless, both states substantially influence adipose tissue (AT) function. Therefore, in this in
Externí odkaz:
https://doaj.org/article/9a796c5a2d4649cebfae37b64651269d
Autor:
Lucas Massier, Jutta Jalkanen, Merve Elmastas, Jiawei Zhong, Tongtong Wang, Pamela A. Nono Nankam, Scott Frendo-Cumbo, Jesper Bäckdahl, Narmadha Subramanian, Takuya Sekine, Alastair G. Kerr, Ben T. P. Tseng, Jurga Laurencikiene, Marcus Buggert, Magda Lourda, Karolina Kublickiene, Nayanika Bhalla, Alma Andersson, Armand Valsesia, Arne Astrup, Ellen E. Blaak, Patrik L. Ståhl, Nathalie Viguerie, Dominique Langin, Christian Wolfrum, Matthias Blüher, Mikael Rydén, Niklas Mejhert
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Single-cell studies of human white adipose tissue (WAT) provide insights into the specialized cell types in the tissue. Here the authors combine publicly available and newly generated high-resolution and bulk transcriptomic results from multiple huma
Externí odkaz:
https://doaj.org/article/403c68977c1d4356b1c8f7dee3850e20
Autor:
Ali Oghabian, Birgitta W. van der Kolk, Pekka Marttinen, Armand Valsesia, Dominique Langin, W. H. Saris, Arne Astrup, Ellen E. Blaak, Kirsi H. Pietiläinen
Publikováno v:
PeerJ, Vol 11, p e15100 (2023)
Background Weight loss effectively reduces cardiometabolic health risks among people with overweight and obesity, but inter-individual variability in weight loss maintenance is large. Here we studied whether baseline gene expression in subcutaneous a
Externí odkaz:
https://doaj.org/article/4fa446ec06d94a00bb134d0471070c08
Autor:
Alastair G. Kerr, Zuoneng Wang, Na Wang, Kelvin H. M. Kwok, Jutta Jalkanen, Alison Ludzki, Simon Lecoutre, Dominique Langin, Martin O. Bergo, Ingrid Dahlman, Carsten Mim, Peter Arner, Hui Gao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Adipocyte-expressed long non-coding RNAs (lncRNAs) have been shown to regulate the transcription of genes involved in lipid metabolism. Here the authors describe a human adipocyte-specific lncRNA, ADIPINT, which regulates lipid metabolism in white ad
Externí odkaz:
https://doaj.org/article/733d5e4bb73b45358b2a2883dd271e1f
Autor:
Matthieu Lacroix, Laetitia K. Linares, Natalia Rueda-Rincon, Katarzyna Bloch, Michela Di Michele, Carlo De Blasio, Caroline Fau, Laurie Gayte, Emilie Blanchet, Aline Mairal, Rita Derua, Fernando Cardona, Diane Beuzelin, Jean-Sebastien Annicotte, Nelly Pirot, Adeline Torro, Francisco J. Tinahones, Florence Bernex, Justine Bertrand-Michel, Dominique Langin, Lluis Fajas, Johannes V. Swinnen, Laurent Le Cam
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The p53 tumor suppressor is also a regulator of metabolism, but the mechanisms controlling p53-associated metabolic activities remain poorly understood. Here the authors report that the deletion of the multifunctional protein E4F1 is protective again
Externí odkaz:
https://doaj.org/article/00ec515c8ba444a682cea51127843aeb
Autor:
Armand Valsesia, Anirikh Chakrabarti, Jörg Hager, Dominique Langin, Wim H. M. Saris, Arne Astrup, Ellen E. Blaak, Nathalie Viguerie, Mojgan Masoodi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Weight loss aims to improve glycemic control in obese but strong variability is observed. Using a multi-omics approach, we investigated differences between 174 responders and 201 non-responders, that had lost >8% body weight following a low-
Externí odkaz:
https://doaj.org/article/b17731f6b55c46028452475f12f8184d
Autor:
Maud Alligier, Romain Barrès, Ellen E. Blaak, Yves Boirie, Jildau Bouwman, Paul Brunault, Kristina Campbell, Karine Clément, I. Sadaf Farooqi, Nathalie J. Farpour-Lambert, Gema Frühbeck, Gijs H. Goossens, Jorg Hager, Jason C.G. Halford, Hans Hauner, David Jacobi, Chantal Julia, Dominique Langin, Andrea Natali, Martin Neovius, Jean Michel Oppert, Uberto Pagotto, Antonio L. Palmeira, Helen Roche, Mikael Rydén, André J. Scheen, Chantal Simon, Thorkild I.A. Sorensen, Luc Tappy, Hannele Yki-Järvinen, Olivier Ziegler, Martine Laville
Publikováno v:
Obesity Facts, Vol 13, Iss 1, Pp 1-28 (2020)
Heterogeneity of interindividual and intraindividual responses to interventions is often observed in randomized, controlled trials for obesity. To address the global epidemic of obesity and move toward more personalized treatment regimens, the global
Externí odkaz:
https://doaj.org/article/a9c0cf2a4a2c498e92626c26cd35d71b
Autor:
Emeline Recazens, Geneviève Tavernier, Jérémy Dufau, Camille Bergoglio, Fadila Benhamed, Stéphanie Cassant-Sourdy, Marie-Adeline Marques, Sylvie Caspar-Bauguil, Alice Brion, Laurent Monbrun, Renaud Dentin, Clara Ferrier, Mélanie Leroux, Pierre-Damien Denechaud, Cedric Moro, Jean-Paul Concordet, Catherine Postic, Etienne Mouisel, Dominique Langin
Publikováno v:
JCI Insight, Vol 7, Iss 4 (2022)
Impaired glucose metabolism is observed in obesity and type 2 diabetes. Glucose controls gene expression through the transcription factor ChREBP in liver and adipose tissues. Mlxipl encodes 2 isoforms: ChREBPα, the full-length form (translocation in
Externí odkaz:
https://doaj.org/article/ef3e53dfce7e4d90ab8aa815f94a0d54
Autor:
Cécilia Colson, Pierre-Louis Batrow, Sebastian Dieckmann, Laura Contu, Christian H. Roux, Laurence Balas, Claire Vigor, Baptiste Fourmaux, Nadine Gautier, Nathalie Rochet, Nathalie Bernoud-Hubac, Thierry Durand, Dominique Langin, Martin Klingenspor, Ez-Zoubir Amri
Publikováno v:
Cells, Vol 12, Iss 3, p 446 (2023)
Obesity is a complex disease highly related to diet and lifestyle and is associated with low amount of thermogenic adipocytes. Therapeutics that regulate brown adipocyte recruitment and activity represent interesting strategies to fight overweight an
Externí odkaz:
https://doaj.org/article/7f11fa2e039647608c31a2d3a57a52e1
Autor:
Joanne X. Shen, Morgane Couchet, Jérémy Dufau, Thais de Castro Barbosa, Maximilian H. Ulbrich, Martin Helmstädter, Aurino M. Kemas, Reza Zandi Shafagh, Marie‐Adeline Marques, Jacob B. Hansen, Niklas Mejhert, Dominique Langin, Mikael Rydén, Volker M. Lauschke
Publikováno v:
Advanced Science, Vol 8, Iss 16, Pp n/a-n/a (2021)
Abstract Obesity and type 2 diabetes are strongly associated with adipose tissue dysfunction and impaired adipogenesis. Understanding the molecular underpinnings that control adipogenesis is thus of fundamental importance for the development of novel
Externí odkaz:
https://doaj.org/article/568a4d59aeaf495091d40d5a6daf16a5