Výsledky vyhledávání - "Dominique L. Kunciw"

Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain - binding peptide macrocycles

Autor: Dominique L. Kunciw, David Hymel, Robert A. Grant, Ramesh M. Chingle, Kohei Tsuji, Terrence R. Burke, Michael B. Yaffe

Publikováno v: Organic & Biomolecular Chemistry

Targeting protein – protein interactions (PPIs) has emerged as an important area of discovery for anticancer therapeutic development. In the case of phospho-dependent PPIs, such as the polo-like kinase 1 (Plk1) polo-box domain (PBD), a phosphorylat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59bdb84f3cacad348c4725478049594
https://pubmed.ncbi.nlm.nih.gov/34346472

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Structural requirements for the antitubercular quaternized triflupromazine pharmacophore

Autor: Miguel O. Mitchell, Jacob J. Liechty, Scott G. Franzblau, Baojie Wan, Dominique L. Kunciw

Publikováno v: Bioorganicmedicinal chemistry letters. 22(17)

Quaternized triflupromazine derivatives (QTDs) must possess benzyl groups attached to the quaternary nitrogen in order to have significant antitubercular potency. Replacing the quaternary amine with a triazole abolishes antitubercular activity. A mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4e80df6c621f5498e9856129e0d9fe
https://pubmed.ncbi.nlm.nih.gov/22850215

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