Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Dominique L Ouellet"'
Autor:
Jean-Paul Iyombe-Engembe, Dominique L Ouellet, Xavier Barbeau, Joël Rousseau, Pierre Chapdelaine, Patrick Lagüe, Jacques P Tremblay
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
The CRISPR/Cas9 system is a great revolution in biology. This technology allows the modification of genes in vitro and in vivo in a wide variety of living organisms. In most Duchenne muscular dystrophy (DMD) patients, expression of dystrophin (DYS) p
Externí odkaz:
https://doaj.org/article/a9147231a34740ca8f85610fbfe3a9c1
Autor:
Khadija Cherif, Catherine Gérard, Joël Rousseau, Dominique L. Ouellet, Pierre Chapdelaine, Jacques P. Tremblay
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 19-32 (2018)
Frataxin gene (FXN) expression is reduced in Friedreich’s ataxia patients due to an increase in the number of GAA trinucleotides in intron 1. The frataxin protein, encoded by that gene, plays an important role in mitochondria’s iron metabolism. P
Externí odkaz:
https://doaj.org/article/c662c1a1cd654951aada49fc008f552b
Autor:
Dominique L. Ouellet, Jacques P. Tremblay, Xavier Barbeau, Joël Rousseau, Jean-Paul Iyombe-Engembe, Benjamin Duchêne, Antoine Guyon, Patrick Lagüe, Khadija Cherif
Publikováno v:
Molecular Therapy. 26:2604-2616
Duchenne muscular dystrophy (DMD), a severe hereditary disease affecting 1 in 3,500 boys, mainly results from the deletion of exon(s), leading to a reading frameshift of the DMD gene that abrogates dystrophin protein synthesis. Pairs of sgRNAs for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e8fc29fc484fe17a092ed8cd1c81d0
https://doi.org/10.1016/j.ymthe.2018.08.010
https://doi.org/10.1016/j.ymthe.2018.08.010
Autor:
Haitang Li, John C. Burnett, Mayumi Takahashi, John J. Rossi, Jerlisa Ann C Arizala, Dominique L. Ouellet
Publikováno v:
AIDS Research and Human Retroviruses
AIDS research and human retroviruses, vol 34, iss 11
AIDS research and human retroviruses, vol 34, iss 11
Combination antiretroviral therapy fails in complete suppression of HIV-1 due to drug resistance and persistent latency. Novel therapeutic intervention requires knowledge of intracellular pathways responsible for viral replication, specifically those
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a69cc680cdcb128d578c8b29f085a9
Publikováno v:
Cell and Gene Therapy Insights. 3:53-58
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93d5c4b37bf3853aafb32b81a4e10541
https://doi.org/10.18609/cgti.2017.003
https://doi.org/10.18609/cgti.2017.003
Autor:
John J. Rossi, Haitang Li, Dominique L. Ouellet, Jerlisa Ann C Arizala, Pritsana Chomchan, Helen Ge, Roger E. Moore
Publikováno v:
Journal of Visualized Experiments.
The HIV-1 infectious cycle requires viral protein interactions with host factors to facilitate viral replication, packaging, and release. The infectious cycle further requires the formation of viral/host protein complexes with HIV-1 RNA to regulate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c419bd1299d9f8878da3d177f79cad
https://doi.org/10.3791/59329
https://doi.org/10.3791/59329
Publikováno v:
Gene Therapy. 24:265-274
The Friedreich ataxia is a monogenic disease due to a hyperexpanded GAA triplet located within the first intron of the frataxin gene that causes transcriptional issues. The resulting frataxin protein deficiency leads to a Fe-S cluster biosynthesis dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f69e481a0191efc3fc22e97d7755295
https://doi.org/10.1038/gt.2016.89
https://doi.org/10.1038/gt.2016.89
Autor:
Pierre Chapdelaine, D Jauvin, Joël Rousseau, Catherine Gérard, Dominique L. Ouellet, Jacques P. Tremblay, N Sanchez, Khadija Cherif
Publikováno v:
Gene Therapy
Artificially designed transcription activator-like effector (TALE) proteins fused to a transcription activation domain (TAD), such as VP64, are able to activate specific eukaryotic promoters. They thus provide a good tool for targeted gene regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bde6882e782eea018d07d83a75f7326
http://europepmc.org/articles/PMC4940929
http://europepmc.org/articles/PMC4940929
Autor:
Benjamin Duchêne, Antoine Guyon, Dominique L. Ouellet, Xavier Barbeau, Joël Rousseau, Jean-Paul Iyombe-Engembe, Jacques P. Tremblay, Khadija Cherif, Patrick Lagüe
Duchenne Muscular Dystrophy (DMD), a severe hereditary disease, affecting 1 boy out of 3500, mainly results from the deletion of one or more exons leading to a reading frame shift of the DMD gene that abrogates dystrophin protein synthesis. We used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839740e357ee3bf07e97534012266ca9
Autor:
Jacques P. Tremblay, Pierre Chapdelaine, Khadija Cherif, Joël Rousseau, Dominique L. Ouellet, Catherine Gérard
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss, Pp 19-32 (2018)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Frataxin gene (FXN) expression is reduced in Friedreich’s ataxia patients due to an increase in the number of GAA trinucleotides in intron 1. The frataxin protein, encoded by that gene, plays an important role in mitochondria’s iron metabolism. P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05eaea15e0c783fe8f3eadfef2294590
https://pubmed.ncbi.nlm.nih.gov/30195758
https://pubmed.ncbi.nlm.nih.gov/30195758