Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Dominique Kernaleguen"'
Publikováno v:
Biochemical Pharmacology. 47:2302-2306
Expression of P-glycoprotein, which confers multidrug resistance to a broad range of anticancer drugs, was studied in rat hepatocytes in culture. P-glycoprotein was localized in the plasma membrane by immunohistochemical staining and was evaluated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54254b07e1c45cf5e3532fe546f298e1
https://doi.org/10.1016/0006-2952(94)90270-4
https://doi.org/10.1016/0006-2952(94)90270-4
Autor:
M. A. Le Bot, Denise Glaise, C. Riche, Dominique Kernaleguen, André Guillouzo, Carlhant D, D. Ratanasavanh
Publikováno v:
Pharmacological Research. 24:243-252
The metabolism of three anthracyclines, namely daunorubicin, doxorubicin and epirubicin, was studied in two human (HepG2 and HBG2) and one rat (FAO) hepatoma cell lines. Both species and substrate differences in anthracycline metabolism were retained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394972fc2181647249850b63d3616aac
https://doi.org/10.1016/1043-6618(91)90087-e
https://doi.org/10.1016/1043-6618(91)90087-e
Publikováno v:
Cancer chemotherapy and pharmacology. 35(1)
The aim of this study was to compare the action of three multidrug resistance (MDR) modulators, cyclosporine A, S 9788, and verapamil, on the efflux of two anthracyclines, doxorubicin and daunorubicin, and of daunorubicinol, the C-13 alcohol metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302a5de7373e717013248c7ca1f78a5c
https://pubmed.ncbi.nlm.nih.gov/7987977
https://pubmed.ncbi.nlm.nih.gov/7987977
Autor:
C. Riche, Y. Guedes, S. Simon, F. Berthou, Jean M. Begue, M. A. Le Bot, Dominique Kernaleguen
Publikováno v:
Biomedical Chromatography. 2:242-244
An HPLC method was used to monitor the chemical stability of doxorubicin-HCl (DXR) to light in plasma, urine and cell culture medium at room temperature. The results indicated that DXR was very unstable in cell culture medium and urine when exposed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0908772e77b4f4cec01b7f562e5e03
https://doi.org/10.1002/bmc.1130020603
https://doi.org/10.1002/bmc.1130020603
Autor:
C. Riche, André Guillouzo, Jacques Airiau, Marie A. Le Bot, Jacques Robert, D. Ratanasavanh, Jean M. Begue, Dominique Kernaleguen
Publikováno v:
Biochemical pharmacology. 37(20)
Both cytotoxicity and metabolism of five anthracyclines, namely doxorubicin, daunorubicin, epirubicin, esorubicin and idarubicin, were investigated in primary cultures of both rat and human adult hepatocytes and, for comparison, in a rat liver epithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1304a1a361076f170408fd65a80ed0a8
https://pubmed.ncbi.nlm.nih.gov/3190734
https://pubmed.ncbi.nlm.nih.gov/3190734