Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation

Autor: Sébastien Thériault, Zhonglin Li, Erik Abner, Jian’an Luan, Hasanga D. Manikpurage, Ursula Houessou, Pardis Zamani, Mewen Briend, Estonian Biobank Research Team, Dominique K. Boudreau, Nathalie Gaudreault, Lily Frenette, Déborah Argaud, Manel Dahmene, François Dagenais, Marie-Annick Clavel, Philippe Pibarot, Benoit J. Arsenault, S. Matthijs Boekholdt, Nicholas J. Wareham, Tõnu Esko, Patrick Mathieu, Yohan Bossé

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract There is currently no medical therapy to prevent calcific aortic valve stenosis (CAVS). Multi-omics approaches could lead to the identification of novel molecular targets. Here, we perform a genome-wide association study (GWAS) meta-analysis

Externí odkaz: https://doaj.org/article/5660b9921e9f456da6aee9115481bb7c

Performance of an RNA-Based Next-Generation Sequencing Assay for Combined Detection of Clinically Actionable Fusions and Hotspot Mutations in NSCLC

Autor: Patrice Desmeules, MD, MSc, Dominique K. Boudreau, MSc, Nathalie Bastien, PhD, Marie-Chloé Boulanger, PhD, Yohan Bossé, PhD, Philippe Joubert, MD, PhD, Christian Couture, MD, MSc

Publikováno v: JTO Clinical and Research Reports, Vol 3, Iss 2, Pp 100276- (2022)

Introduction: With its expanding list of approved and emerging therapeutic indications, NSCLC is the exemplar tumor type requiring upfront assessment of several biomarkers to guide clinical management. Next-generation sequencing allows identification

Externí odkaz: https://doaj.org/article/c560105466154866b168332eaa811208

Data from Tumor Mutational Burden by Whole-Genome Sequencing in Resected NSCLC of Never Smokers

Autor: Yohan Bossé, Philippe Joubert, Patrice Desmeules, Christian Couture, Catherine Labbé, Maria Teresa Landi, Tongwu Zhang, Dominique K. Boudreau, Victoria Saavedra Armero, Cyndi Henry, Nathalie Gaudreault, Zhonglin Li, Louis-Jacques Ruel

Background:Data are scarce about tumor mutational burden (TMB) as a biomarker in never smokers with non–small cell lung cancer (NSCLC).Methods:TMB was assessed by whole-genome sequencing (WGS) and compared with in silico reduced whole-exome sequenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291479b229781ff3b8deec078092af01
https://doi.org/10.1158/1055-9965.c.6660322

The 12th Edition of the Scientific Days of the National Institute for Infectious Diseases 'Prof. Dr. Matei Bals' and the 12th National Infectious Diseases Conference

Autor: Cristian-Mihail Niculae, Eliza Manea, Raluca Jipa, Simona Merisor, Ruxandra Moroti, Serban Benea, Adriana Hristea, Alina Cristina Neguț, Oana Săndulescu, Anca Streinu-Cercel, Dana Mărculescu, Magdalena Lorena Andrei, Veronica Ilie, Marcela Popa, Coralia Bleotu, Carmen Chifiriuc, Mircea Ioan Popa, Adrian Streinu-Cercel, Alina Orfanu, Cristina Popescu, Anca Leuștean, Remulus Catană, Anca Negru, Alexandra Badea, Radu Orfanu, Cătălin Tilișcan, Victoria Aramă, Ştefan Sorin Aramă, Constanța-Angelica Vișan, Anca-Cristina Drăgănescu, Anuța Bilașco, Camelia Kouris, Mădălina Merișescu, Magdalena Vasile, Diana-Maria Slavu, Sabina Vintilă, Endis Osman, Alina Oprea, Sabina Sandu, Monica Luminos, Anca Leuştean, Gabriel Adrian Popescu, Ramona Georgiana Stanculete, Ana Vaduva Enoiu, Adelina Raluca Marinescu, Voichita Lazureanu, Adelina-Raluca Marinescu, Alexandru Crișan, Voichița Lăzureanu, Virgil Musta, Narcisa Nicolescu, Ruxandra Laza, Anca-Ruxandra Negru, Daniela-Ioana Munteanu, Raluca Mihăilescu, Olga Dorobăț, Alexandru Rafila, Emilia Căpraru, Marius Niculescu, Rodica Marinescu, Olivera Lupescu, Vlad Predescu, Daniela Tălăpan, Ramona Ștefania Popescu, Luminița Bradu, Dragoș Florea, Daniela Anicuta Leca, Elena Bunea, Andra Teodor, Egidia Miftode, Gheorghiță Jugulete, Anamaria Dobrotă, Adina Ilie, Liliana Lucia Preoțescu, Nicoleta Irimescu, Irina Panait, Cristian Niculae, Liana Cătălina Gavriliu, Otilia Elisabeta Benea, Șerban Benea, Mona Popoiu, Livia Dragonu, Augustin Cupşa, Iulian Diaconescu, Irina Niculescu, Lucian Giubelan, Florentina Dumitrescu, Andreea Cristina Stoian, Camelia Guţă, Simona Puiu, Bunescu Irina, Marilyse Vallée, Ann Huletsky, Dominique K. Boudreau, Ève Bérubé, Richard Giroux, Jean Longtin, Yves Longtin, Michel G. Bergeron, Cleo Nicoleta Roșculeț, Dalila-Ana Toma, Catrinel Ciuca, Cătălin Apostolescu, Andrei Rogoz, Andrei Stangaciu, Viorica Mitescu, Tudor Vladoiu, Doina Iovănescu, Michaela Oana, Simona Costin, Maria Magdalena Moțoi, Olga Mihaela Dorobăț, Alexandru Mihai, Cleo Roşculeț, Gabriel-Adrian Popescu, Adrian Abagiu, Ruxandra Moroti-Constantinescu, Otilia Benea, Mădălina Simoiu, Rodica Bacruban, Ioana Bădicuț, Alina Borcan, Mihnea Hurmuzache, Georgiana Enache, Alexandra Ciocan, Mircea Bararu, Madalina Popazu, Doina Viorica Iovănescu, Cătălin Gabriel Apostolescu, Dalila Toma, Laura Iliescu, Georgiana Minzala, Letitia Toma, Mihaela Baciu, Alina Tanase, Carmen Orban, Victor Pantea, Gheorghe Placinta, Valentin Cebotarescu, Lilia Cojuhari, Paulina Jimbei, Cristina Dragomirescu, Cristina Murariu, Laurențiu Stratan, Daniela Munteanu, Raluca Năstase, Violeta Molagic, Mihaela Rădulescu, Ioan Diaconu, Iulia Bodosca, Violeta Niță, Raluca Mihaela Năstase, Iulia Bodoșca, Ioan Alexandru Diaconu, Yagmur Erturk, Claudiu Mihai Șchiopu, Angelica Tenita, Ștefan Sorin Aramă, Simona Alexandra Iacob, Diana Gabriela Iacob, Mioara Predescu, Alexandra Mărdărescu, Mihai Săndulescu, Catrinel Olimpia Ciuca, Dalila Ana Toma, Cristina Elena Mitu, Viorica Daniela Mitescu, Tudor Gheorghe Vladoiu, Monica Andreea Stoica, Daniela Manolache, Gabriela Jana Ceapraga, Gabriela Mircea, Ionel Durbală, Irina Russu, Tiberiu Holban, Tatiana Pantilimonov, Galina Chiriacov, Arcadie Macvovei, Elena Scorohodico, Oleg Dmitriev, Diana Alexandra Costache, Anca Benea, Elisabeta Benea, Mihai Mitran, Carmen Georgescu, Loredana Mitran, Simona Vladareanu, Andreea Ioana Magirescu, Viorica Andreev, Cristina Nicolau, Alexandra Largu, Carmen Dorobat, Carmen Manciuc, Ina Isac, Iulia Gabriela Șerban, Ghiulendan Resul, Consuela Marcaș, Iosif Marincu, Patricia Poptelecan, Bogdan Trincă, Sorina Mitrescu, Anca Tudor, Daliborca Vlad, Livius Tirnea, Nurcan Baydaroglu, Gabriela Ceapraga, Mariana Pagute, Carmen Dorobăț, Ioan-Alexandru Diaconu, Daniela Ion, Luciana Nichita, Alexandra Diaconu, Irina Duport-Dodot, Mariana Mărdărescu, Cristina Petre, Marieta Iancu, Rodica Ungurianu, Alina Cibea, Ruxandra Drăghicenoiu, Ana Maria Tudor, Delia Vlad, Sorin Petrea, Carina Matei, Dan Oțelea, Carmen Crăciun, Cristian Anghelina, Elena Dumea, Sorin Rugină, Lucian Cristian Petcu, Stela Halichidis, Simona Claudia Cambrea, Carmen Chiriac, Nina-Ioana Bodnar, Iringo-Erzsebet Zaharia-Kezdi, Cristina Gîrbovan, Andrea Incze, Anca Meda Georgescu, Eugenia Panaitescu, Manole Cojocaru, Vochita Laurențiu, Vochita Andreia, Opreanu Radu, Trinca Bogdan, Rosca Ovidiu, Marincu Iosif, Ramona Zamfir, Alina Angelescu, Alena Andreea Popa, Liana Gavriliu, Alena-Andreea Popa, Georgeta Ducu, Daniela Camburu, Alina Cozma, Manuela Podani, Roxana Dumitriu, Augustin Cupșa, Loredana Ionescu, Adrian Octavian Abagiu, Loredana Nicoleta Stoica, Catrinel Blaga, Archontis Koulosousas, Roxana Ștefănescu, Alice Atomoaie, Florentina Paraschiv, Florin Matache Duna, Rodica Olteanu, Roxana Ion, Alexandra Zota, Isra Ennour Jaballah, Lara Mahfoud, Georgeta Preda, Magda Constantin, Ilinca Nicolae, Corina Daniela Ene, Mădălina Irina Mitran, Vasile Benea, Mircea Tampa, Simona Roxana Georgescu, Iulia Cristina Bodoșca, Sorin Aramă, Iuliana Caramăngiu, Ovidiu Rosca, Monica Cialma, Radu Opreanu, Laurențiu Vochita, Vlad Murărescu, Marilena Palaghiță, Cornel Camburu, Irina Duşan, Andreea Bîrlad, Victor Daniel Miron, Anca Cristina Drăgănescu, Daniela Pițigoi, Monica Luminița Luminos, Sabina Șchiopu, Magda Vasile, Mihaela Ionică, Adina Stăncescu, Cristina Elena Popescu, Luminița Marin, Diana Zaharia, Cristina Dumitrescu, Lucia Tudor, Cristina Negulescu, Olga Adriana Caliman-Sturdza, Cleo Roșculeț, Bogdana Manu, Ana Vaduva-Enoiu, Voichita Elena Lazureanu, Elena-Violeta Niță, Sînziana Dumitru, Anca Ruxandra Negru, Ligia Ionescu, Liliana Ion, Marioara Neacșu, Cristina Iulia Mitran, George Ciprian Pribac, Mirandolina Prisca, Fulvia Ursoiu, Carmen Neamtu, Bogdan Totolici, Coralia Cotoraci, Aurel Ardelean, Simona Elena Albu, Mara Carsote, Beatrice Miclăuș, Diana Mihai, Cristina Vasiliu, Corina Gorgoi, Amelia Blescun, Gelu Breaza, Sabina Vintila, Felicia Mihai, Meilin Omer, Cornel Dragan, Daniela Pitigoi, Mirela Ciucu, Marius-Dan Ionescu, Cristina Roskanovic, Valentina Barbu, Ramona-Alexandra Zamfir, Alexandra-Sînziana Dumitru, Viorica Ispas, Diana Oana Leahu, Cristina Maria Safta, Mihaela Anca Benea, Octavian Munteanu, Roxana Bohâlțea, Livia Trașcă, Monica Cîrstoiu, Mădălina Georgescu, Alina Elena Ivanciuc, Mihaela Lazar, Teodora Ionescu, Carmen Maria Cherciu, Cristina Țecu, Maria Elena Mihai, Maria Nițescu, Delia Azamfire, Aura Dumitrescu, Elena Ianosik, Daniela Leca, Elena Duca, Codrina Bejan, Emanoil Ceaușu, Simin-Aysel Florescu, Corneliu Popescu, Grațiela Târdei, Codrina Juganariu, Emilia Lupulescu, Ligia Rodina, Maria Elena Cocuz, Andreea Stoian, Mihaela Ionica, Otilia-Elisabeta Benea, Maria-Cristina Sîrbu, AnaMaria Dobrotă, Roxana Duda, Cristiana Cerasella Dragomirescu, Sergiu Fendrihan, Ecaterina Scortan, Corneliu P. Popescu, Șerban N. Benea, Andra E. Petcu, Iuliana A. Podea, Raluca E. Jipa, Raluca M. Hrișcă, Manuela Nica, Simona Merișor, Cristian M. Nicolae, Simin A. Florescu, Irina M. Dumitru, Ruxandra V. Moroti, Bogdan Nițescu, Iulia Monica Mustaţă, Sorina Claudia Boldeanu, Florentina Furtunescu, Mihaela Gheorghe, Adriana Slavcovici, Raluca Tripon, Roxana Iubu, Cristian Marcu, Mihaela Sabou, Monica Muntean, Ion Chiriac, Liviu Tazlavanu, Roxana Cernat, Kezdi Iringo, Andrei Vâță, Manuela Arbune, Teodora Moisil, Corina-Daniela Ene, Roxana Simona Georgescu, Cosmin-Victor Ene, Marilena Ciortea, Lucreția Dulgheru, Mihaela Cătălina Luca, Ioana-Alina Harja-Alexa, Roxana Nemescu, Mădălina Popazu, Andrei Ștefan Luca, Gabriela Bancescu, Bogdan Dabu, Adrian Bancescu, Adina Elena Ilie, Săftica-Mariana Pohrib, Maria-Sabina Tache, Ion Aurel Iliescu, Cristina Tecu, Maria-Elena Mihai, Mihaela Lazăr, Carmen Cherciu, Alina Ivanciuc, Mirela Paliu, Manuela Curescu, Bianca Cerbu, Irina Bunescu, Ana Pasnin, Stela Semeniuc, Raisa Popovici

Publikováno v: BMC Infectious Diseases, Vol 16, Iss S4, Pp 31-76 (2016)

Table of contents A1 The outcome of patients with recurrent versus non-recurrent pneumococcal meningitis in a tertiary health-care hospital in Bucharest Cristian-Mihail Niculae, Eliza Manea, Raluca Jipa, Simona Merisor, Ruxandra Moroti, Serban Benea,

Externí odkaz: https://doaj.org/article/1ed174758da44a8190c095404074fffa

Abstract P1-20-09: Does a single-dose of pre-operative prophylactic antibiotic reduce surgical site infection following wire-localized lumpectomy?

Autor: Brigitte Poirier, Christine Desbiens, Louise Provencher, Éric Poirier, Dominique Leblanc, Gabrielle Bergeron Giguère, Dominique K. Boudreau, Jean-Charles Hogue

Publikováno v: Cancer Research. 80:P1-20

Background: Data on the benefits of preoperative prophylactic antibiotics for breast surgery are conflicting and there is no guideline for their use for wire-localized lumpectomy. The aims of this study were to determine whether a single dose of pre-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d75bf5329be07d45f25e0ecfb1d34d9f
https://doi.org/10.1158/1538-7445.sabcs19-p1-20-09