Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Dominique Jean-Pierre Mabire"'
Autor:
Dominique Jean-Pierre Mabire, Alain Philippe Poncelet, Anne Simone Josephine Lesage, Ludy van Beijsterveldt, François Paul Bischoff, Ria Wouters, Christophe Adelinet, Yvan Rene Simonnet, Sophie Coupa, Marc Venet
Publikováno v:
Journal of Medicinal Chemistry. 48:2134-2153
We describe the discovery and the structure-activity relationship of a new series of quinoline derivatives acting as selective and highly potent noncompetitive mGlu1 antagonists. We first identified cis-10 as a fairly potent mGlu1 antagonist (IC(50)
Autor:
Chi Hung Nguyen, Elisabeth Thérèse Jeanne Pasquier, Dominique Jean-Pierre Mabire, Koen Andries, Jerome Emile Georges Guillemont, Abdellah Benjahad, David S. Grierson, Said Oumouch
Publikováno v:
Bioorganic and medicinal chemistry letters
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2007, 17 (3), pp.712-6. ⟨10.1016/j.bmcl.2006.10.082⟩
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2007, 17 (3), pp.712-6. ⟨10.1016/j.bmcl.2006.10.082⟩
As part of a systematic SAR study on the 3-iodo-4-phenoxypyridinone 3 (IOPY) type non-nucleoside reverse transcriptase inhibitors, the analogues 4a-4z bearing different C-3 substituents were synthesized and evaluated for their anti-HIV activity again
Autor:
Dominique Jean-Pierre Mabire, Koen Andries, Chi Hung Nguyen, Alain Philippe Poncelet, Martine Croisy, Daniel M. Himmel, Christophe Meyer, Claude Monneret, Eddy Arnold, R Pauwels, Marie-Pierre de Béthune, Sophie Coupa, Kalyan Das, David Grierson, Jerome Emile Georges Guillemont, Abdellah Benjahad, Csoka Imre Christian Francis, Emile Bisagni
Publikováno v:
Journal of medicinal chemistry
In a program to optimize the anti-HIV activity of the 4-benzyl and 4-benzoyl-3-dimethylaminopyridinones 9 and 10, lead compounds in a new class of highly potent non-nucleoside type inhibitors of HIV-1 reverse transcriptase, modification of the alkyl