Interaction of detergents with biological membranes: Comparison of fluorescence assays with filtration protocols and implications for the rates of detergent association, dissociation and flip-flop.

Autor: Philippe Champeil, Béatrice de Foresta, Martin Picard, Carole Gauron, Dominique Georgin, Marc le Maire, Jesper V Møller, Guillaume Lenoir, Cédric Montigny

Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0222932 (2019)

The present study mainly consists of a re-evaluation of the rate at which C12E8, a typical non-ionic detergent used for membrane studies, is able to dissociate from biological membranes, with sarcoplasmic reticulum membrane vesicles being used as an

Externí odkaz: https://doaj.org/article/4aa83949c10942028c6720c14d91f2f1

Correlative radioimaging and mass spectrometry imaging: a powerful combination to study 14C-graphene oxide in vivo biodistribution

Autor: Hélène Cazier, Carole Malgorn, Dominique Georgin, Nathalie Fresneau, Fabrice Beau, Kostas Kostarelos, Cyrill Bussy, Stéphane Campidelli, Mathieu Pinault, Martine Mayne-L'Hermite, Frédéric Taran, Christophe Junot, François Fenaille, Antoine Sallustrau, Benoit Colsch

Publikováno v: Cazier, H, Malgorn, C, Georgin, D, Fresneau, N, Beau, F, Kostarelos, K, Bussy, C, Campidelli, S, Pinault, M, Mayne-L'hermite, M, Taran, F, Junot, C, Fenaille, F, Sallustrau, A & Colsch, B 2023, ' Correlative radioimaging and mass spectrometry imaging: a powerful combination to study 14 C-graphene oxide in vivo biodistribution ', Nanoscale, vol. 15, no. 11, pp. 5510-5518 . https://doi.org/10.1039/D2NR06753F

Research on graphene based nanomaterials has flourished in the last decade due their unique properties and emerging socio-economic impact. In the context of their potential exploitation for biomedical applications, there is a growing need for the dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206fd036aac7edbe46d1e453c38cc044
https://research.manchester.ac.uk/en/publications/e536229c-7993-46a9-b902-3a0ce705732b

Palladium-catalyzed decarboxylative cyanation of aromatic carboxylic acids using [13C] and [14C]-KCN

Autor: Olivier Loreau, Dominique Georgin, Frédéric Taran, Davide Audisio

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 58:425-428

The development of robust and straightforward methods to efficiently label aromatic moieties starting from simple and convenient radio-synthetic sources still represents a considerable challenge. In this report, a new palladium-catalyzed decarboxylat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0cbbcf4d3788c0e8d1be2c62bdcdef6
https://doi.org/10.1002/jlcr.3330

Gel chromatography and analytical ultracentrifugation to determine the extent of detergent binding and aggregation, and Stokes radius of membrane proteins using sarcoplasmic reticulum Ca2+–ATPase as an example

Autor: Claus Olesen, Christine Ebel, Marc le Maire, Dominique Georgin, Bertrand Arnou, Jesper V. Møller

Publikováno v: Nature Protocols. 3:1782-1795

For structural studies of integral membrane proteins, including their 3D crystallization, the judicious use of detergent for solubilization and purification is required. Detergent binding by the solubilized protein is an important parameter to determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a210c39a10f880f895f6a566b25bc7
https://doi.org/10.1038/nprot.2008.177

A relevant in vitro rat model for the evaluation of blood-brain barrier translocation of nanoparticles

Autor: Karine Andrieux, V. Nicolas, Françoise Roux, Didier Desmaële, Patrick Couvreur, E. Garcia-Garcia, Dominique Georgin, Frédéric Taran, Jean-Paul Andreux, Sophie Gil

Publikováno v: Cellular and Molecular Life Sciences

Poly(MePEG2000cyanoacrylate-co-hexadecylcyanoacrylate) (PEG-PHDCA) nanoparticles have demonstrated their capacity to reach the rat central nervous system after intravenous injection. For insight into the transport of colloidal systems across the bloo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6508aaba2ae8e3f03e78e0f42881feb
https://doi.org/10.1007/s00018-005-5094-3