Localized proteomic differences in the choroid plexus of Alzheimer's disease and epilepsy patients

Autor: Dominique F. Leitner, Evgeny Kanshin, Arline Faustin, Manon Thierry, Daniel Friedman, Sasha Devore, Beatrix Ueberheide, Orrin Devinsky, Thomas Wisniewski

Publikováno v: Frontiers in Neurology, Vol 14 (2023)

IntroductionAlzheimer's disease (AD) and epilepsy are reciprocally related. Among sporadic AD patients, clinical seizures occur in 10–22% and subclinical epileptiform abnormalities occur in 22–54%. Cognitive deficits, especially short-term memory

Externí odkaz: https://doaj.org/article/2bf3fce1d01a4e4497be3296caf34c2d

Metabolomic, proteomic, and transcriptomic changes in adults with epilepsy on modified Atkins diet

Autor: Dominique F. Leitner, Yik Siu, Aryeh Korman, Ziyan Lin, Evgeny Kanshin, Daniel Friedman, Sasha Devore, Beatrix Ueberheide, Aristotelis Tsirigos, Drew R. Jones, Thomas Wisniewski, Orrin Devinsky

Publikováno v: Epilepsia. 64:1046-1060

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37f72ab620acc43cb4e8836a91432780
https://doi.org/10.1111/epi.17540

Brain molecular mechanisms in Rasmussen encephalitis

Autor: Dominique F. Leitner, Ziyan Lin, Zacharia Sawaged, Evgeny Kanshin, Daniel Friedman, Sasha Devore, Beatrix Ueberheide, Julia W. Chang, Gary W. Mathern, Jasper J. Anink, Eleonora Aronica, Thomas Wisniewski, Orrin Devinsky

Publikováno v: Epilepsia. Wiley-Blackwell
Leitner, D F, Lin, Z, Sawaged, Z, Kanshin, E, Friedman, D, Devore, S, Ueberheide, B, Chang, J W, Mathern, G W, Anink, J J, Aronica, E, Wisniewski, T & Devinsky, O 2022, ' Brain molecular mechanisms in Rasmussen encephalitis ', Epilepsia . https://doi.org/10.1111/epi.17457

Objective: This study was undertaken to identify molecular mechanisms in brain tissue of Rasmussen encephalitis (RE) when compared to people with non-RE epilepsy (PWE) and control cases using whole exome sequencing (WES), RNAseq, and proteomics. Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ca0926748046f34485d30087bfaab1
https://pubmed.ncbi.nlm.nih.gov/36336987

Semaphorin4A Is Cytotoxic to Oligodendrocytes and Is Elevated in Microglia and Multiple Sclerosis

Autor: Dominique F. Leitner, Bozho Todorich, Xuesheng Zhang, James R. Connor

Publikováno v: ASN Neuro, Vol 7 (2015)

We have previously established that T cell immunoglobulin and mucin domain containing 2 (Tim2) is an H-ferritin receptor on oligodendrocytes (OLs). Tim2 also binds Semaphorin4A (Sema4A). Sema4A is expressed by lymphocytes, and its role in immune acti

Externí odkaz: https://doaj.org/article/aab1c7dd32a14f08a0b82398af08a4f8

Blinded review of hippocampal neuropathology in sudden unexplained death in childhood reveals inconsistent observations and similarities to explained paediatric deaths

Autor: R. Ross Reichard, Orrin Devinsky, Heather S Jarrell, Dominique F Leitner, Manor Askenazi, Declan McGuone, Victor Weedn, Christopher William, Matija Snuderl, Colin Smith, Arline Faustin, Melissa Guzzetta, Thomas Wisniewski, Laura Gould, Katherine Maloney

Publikováno v: Neuropathol Appl Neurobiol

AIMS: Hippocampal findings are implicated in the pathogenesis of sudden unexplained death in childhood (SUDC), although some studies have identified similar findings in sudden explained death in childhood (SEDC) cases. We blindly reviewed hippocampal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f56c8c0bca56f9c419797b04f6b60a
https://pubmed.ncbi.nlm.nih.gov/34164845