Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Dominique Damour"'
Autor:
Jeremy Pratt, Guillaume Birraux, Patrick Jimonet, Alain Boireau, Jean Marie Stutzmann, Serge Mignani, Arielle Genevois-Borella, Dominique Damour, Florence Wahl, Marc Williams Debono, Marc Vuilhorgne, Georg Andrees Bohme
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:1627-1637
Excessive release of glutamate, a potent excitatory neurotransmitter, is thought to play an important role in a variety of acute and chronic neurological disorders, suggesting that excitatory amino acid antagonists may have broad therapeutic potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f8ad3bdc58720bd70bc789f47bb6c7
https://doi.org/10.1016/s0968-0896(01)00431-x
https://doi.org/10.1016/s0968-0896(01)00431-x
Autor:
Marc Williams Debono, Patrick Jimonet, Arielle Genevois-Borella, John Randle, Yves Ribeill, Serge Mignani, Alain Boireau, Dominique Damour, Marc Vuilhorgne, Georg Andrees Bohme, Jean-Marie Stutzmann, Jeremy Pratt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1205-1210
The overstimulation of excitatory amino acid receptors such as the glutamate AMPA receptor has been implicated in the physiopathogenesis of epilepsy as well as in acute and chronic neurodegenerative disorders. An original series of readily water solu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1be2de3f0a9672b1df14d4985d7b501e
https://doi.org/10.1016/s0960-894x(01)00180-9
https://doi.org/10.1016/s0960-894x(01)00180-9
Autor:
Arielle Genevois-Borella, Georg Andrees Bohme, Franco Manfre, Alain Boireau, Yves Ribeill, Marc Williams Debono, Patrick Jimonet, Jean-Marie Stutzmann, Jeremy Pratt, Dominique Damour, Jean Bouquerel, Philippe Hubert, Marc Vuilhorgne, John Randle, Patrick Nemecek, Jean-Claude Hardy, Serge Mignani
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:127-132
A novel series of 2- and 9-disubstituted heterocyclic-fused 4-oxo-indeno[1,2- e ]pyrazin derivatives was synthesized. One of them, the 9-(1 H -tetrazol-5-ylmethyl)-4-oxo-5,10-dihydroimidazo[1,2- a ]indeno[1,2- e ]pyrazin-2-yl phosphonic acid 4i exhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ac0e92b179b6bdf461d575d0a942d3
https://doi.org/10.1016/s0960-894x(00)00592-8
https://doi.org/10.1016/s0960-894x(00)00592-8
Autor:
John Randle, Alain Boireau, Jean-Marie Stutzmann, Patrick Jimonet, Jeremy Pratt, Dominique Damour, Arielle Genevois-Borella, Serge Mignani, Marc Williams Debono, Marc Vuilhorgne, Yves Ribeill, Georg Andrees Bohme
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2749-2754
The over-stimulation of excitatory amino acid receptors such as the glutamate AMPA receptor has been suggested to be associated with neurodegenerative disorders. Here we describe an original series of readily water soluble 4-oxo-imidazo[1,2-a] indeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10737b7c9953a61e4271b1d429d74468
https://doi.org/10.1016/s0960-894x(00)00561-8
https://doi.org/10.1016/s0960-894x(00)00561-8
Autor:
Jean-Marie Stutzmann, Marc Williams Debono, Alain Boireau, Arielle Genevois-Borella, Michel Cheve, Dominique Damour, Assunta Imperato, John Randle, Yves Ribeill, Jeremy Pratt, Serge Mignani, Patrick Jimonet, Marc Vuilhorgne, Georg Andrees Bohme
Publikováno v:
Bioorganic & Medicinal Chemistry. 8:2211-2217
Water soluble 8-methylureido-10-amino-10-methyl-imidazo[1,2-a]indeno[1,2-e]pyraz ine-4-one 4 represents a novel class of highly potent and selective AMPA receptors antagonists with in vivo activity. The dextrorotatory isomer (+)-4 was found to displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675b2882dda673cbc94a2c3686682c41
https://doi.org/10.1016/s0968-0896(00)00161-9
https://doi.org/10.1016/s0968-0896(00)00161-9
Autor:
Jeremy Pratt, Arielle Genevois-Borella, Michel Cheve, Georg Andrees Bohme, Yves Ribeill, Franco Manfre, Patrick Jimonet, Jean Marie Stutzmann, Alain Boireau, S. Le Guern, A. Doble, John Randle, Serge Mignani, F. Herman, Dominique Damour, Assunta Imperato
Publikováno v:
Journal of Medicinal Chemistry. 43:2371-2381
Indeno[1,2-b]pyrazin-2,3-diones have been identified as a novel series of potent ligands on the glycine site of the NMDA receptor. To improve their in vivo activities, an acetic acid-type side chain was introduced to the 5-position, giving water-solu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb6bb95b505689a045ccf42c7891307
https://doi.org/10.1021/jm990957g
https://doi.org/10.1021/jm990957g
Autor:
Jean-Marie Stutzmann, Marc Vuilhorgne, Yves Ribeill, Serge Mignani, Jeremy Pratt, Patrick Jimonet, Dominique Damour, Alain Boireau, Marc Williams Debono, Georg Andrees Bohme, John Randle, Assunta Imperato, Arielle Genevois-Borella
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1133-1137
A novel series of 2-substituted-4,5-dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazine derivatives was synthesised. One of them, Figure 1 , Scheme 1 Download : Download high-res image (100KB) Download : Download full-size image Figure 1 . Download
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b66de283ed6371978c03010cf974ec2a
https://doi.org/10.1016/s0960-894x(00)00181-5
https://doi.org/10.1016/s0960-894x(00)00181-5
Autor:
Yves Ribeill, John Randle, Michel Reibaud, Jeremy Pratt, Jean-Marie Stutzmann, J.‐C. Blanchard, Alain Boireau, Marie-Christine Dubroeucq, Arielle Genevois-Borella, Marc-Williams Debono, Serge Mignani, Dominique Damour, Jean-Claude Aloup, Patrick Jimonet, Assunta Imperato, Georg Andrees Bhme, Michel Barreau
Publikováno v:
Drug Development Research. 48:121-129
The excessive release of glutamate, a potent excitatory neurotransmitter, is thought to play an important role in a variety of acute and chronic neurological disorders. Consequently, excitatory amino acid antagonists may have an important therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24f48bd64e67bb86b4bdcec16f6c78d9
https://doi.org/10.1002/(sici)1098-2299(199911)48:3<121::aid-ddr4>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199911)48:3<121::aid-ddr4>3.0.co
Autor:
Jean-Marie Stutzmann, John Randle, Assunta Imperato, Michel Cheve, Yves Ribeill, Jeremy Pratt, Dominique Damour, Arielle Genevois-Borella, Patrick Jimonet, Serge Mignani, Alain Boireau
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2921-2926
Original spiro-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one derivatives were synthesised and led to the identification of 3e which showed good affinities for both the AMPA and the NMDA glycine-site receptors, and displayed good anticonvulsant effects af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329d2e1edcaabf2f7e171129a95f6327
https://doi.org/10.1016/s0960-894x(99)00502-8
https://doi.org/10.1016/s0960-894x(99)00502-8
Autor:
Dominique Damour, Guy Pantel, Richard Labaudiniere, Marc Vuilhorgne, Frédéric Herman, Serge Mignani
Publikováno v:
Tetrahedron. 55:10135-10154
Original proline or γ-lactam derivatives bearing either an aryl group such as a phenyl or a 3-indolyl in position 3 of the proline moiety or on the 3-methyl chain of the γ-lactam skeleton were prepared as non-peptide mimics of Somatostatin/Sandosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb6ecbd63a44458b27b487f0ac5dc560
https://doi.org/10.1016/s0040-4020(99)00561-x
https://doi.org/10.1016/s0040-4020(99)00561-x