Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Dominique Custeau"'
Autor:
Sally Loi, Lac Lee, Jean Regard, Dominique Custeau, Andrew Patterson, Lin Deng, Julien Papillon, Aimee Reynolds, Tyler Harrison, Micah Hollis-Symynkywicz, Jovita Marcinkeviciene, Lawrence G. Hamann, Anup Patnaik, Xianglin Ren, Jutta Blank, Nigel Casson, Laura Axford, Toshiyuki Honda, Lisa Ames, Lihe Zhang, Martin L. Marro
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 367(1)
Myeloperoxidase (MPO) is a leukocyte-derived redox enzyme that has been linked to oxidative stress and damage in many inflammatory states, including cardiovascular disease. We have discovered aminopyridines that are potent mechanism-based inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444de565ea988076b4b032134228dce7
https://pubmed.ncbi.nlm.nih.gov/30076263
https://pubmed.ncbi.nlm.nih.gov/30076263
Autor:
Henriette Gourdeau, Lorraine Leblond, Bettina Hamelin, Kelly Dong, France Ouellet, Chantal Boudreau, Dominique Custeau, Annie Richard, Marie-Josée Gilbert, Jacques Jolivet
Publikováno v:
Clinical Cancer Research. 10:7692-7702
Purpose: Troxacitabine is the first unnatural l-nucleoside analog to show potent preclinical antitumor activity and is currently under clinical investigation. Significant differences in troxacitabine toxicity between mice, rats, monkeys, and humans w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17ca7db8a0dc26f0f565cafb96ccbe64
https://doi.org/10.1158/1078-0432.ccr-04-0657
https://doi.org/10.1158/1078-0432.ccr-04-0657
Autor:
Henriette Gourdeau, Lorraine Leblond, Bettina Hamelin, Clemence Desputeau, Kelly Dong, Irenej Kianicka, Dominique Custeau, Chantal Boudreau, Lilianne Geerts, Sui-Xiong Cai, John Drewe, Denis Labrecque, Shailaja Kasibhatla, Ben Tseng
Publikováno v:
Molecular Cancer Therapeutics. 3:1375-1384
A novel series of 2-amino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4H-chromenes was identified as potent apoptosis inducers through a cell-based high throughput screening assay. Six compounds from this series, MX-58151, MX-58276, MX-76747, MX-116214,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84b8df55ad4d1b0e77e932e397bb8d1f
https://doi.org/10.1158/1535-7163.1375.3.11
https://doi.org/10.1158/1535-7163.1375.3.11
Autor:
Henriette Gourdeau, Lucie Bibeau, France Ouellet, Dominique Custeau, Louise Bernier, Terry Bowlin
Publikováno v:
Cancer Chemotherapy and Pharmacology. 47:236-240
Purpose: Troxacitabine (β-L-dioxolane cytidine, BCH-4556; Troxatyl, BioChem Pharma Inc.) is a novel nucleoside analogue, which in experiments demonstrated potent antitumor activity against both leukemias and solid tumors. Since troxacitabine is a cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1acf0fcad78bab96dac8c8e44d003f
https://doi.org/10.1007/s002800000223
https://doi.org/10.1007/s002800000223
Autor:
Dominique Custeau, Srinivasu Poondru, Qing Ye, Minhui Shen, Donald J. Cook, Jay Ezhuthachan, Michael Howard Block, Lee John W, Paul Lyne, Scott David, Allan Wu, Mei Su, Lisa Drew, Timothy Pontz, Les A. Dakin, Stephanos Ioannidis, Tracy L. Deegan, Scott Cowen, Brian Aquila, Xiaolan Zheng
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(3)
A series of amidoheteroaryl compounds were designed and synthesized as inhibitors of B-Raf kinase. Several compounds from the series show excellent potency in biochemical, phenotypic and mode of action cellular assays. Potent examples from the series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96353995ce932346b9bc19c7be48312
https://pubmed.ncbi.nlm.nih.gov/19097792
https://pubmed.ncbi.nlm.nih.gov/19097792
Autor:
Henriette, Gourdeau, Lorraine, Leblond, Bettina, Hamelin, Kelly, Dong, France, Ouellet, Chantal, Boudreau, Dominique, Custeau, Annie, Richard, Marie-Josée, Gilbert, Jacques, Jolivet
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 10(22)
Troxacitabine is the first unnatural L-nucleoside analog to show potent preclinical antitumor activity and is currently under clinical investigation. Significant differences in troxacitabine toxicity between mice, rats, monkeys, and humans were obser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b95d0f4c45928e17add2b4f8d9d768c
https://pubmed.ncbi.nlm.nih.gov/15570003
https://pubmed.ncbi.nlm.nih.gov/15570003
Autor:
Henriette, Gourdeau, Lorraine, Leblond, Bettina, Hamelin, Clemence, Desputeau, Kelly, Dong, Irenej, Kianicka, Dominique, Custeau, Chantal, Boudreau, Lilianne, Geerts, Sui-Xiong, Cai, John, Drewe, Denis, Labrecque, Shailaja, Kasibhatla, Ben, Tseng
Publikováno v:
Molecular cancer therapeutics. 3(11)
A novel series of 2-amino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4H-chromenes was identified as potent apoptosis inducers through a cell-based high throughput screening assay. Six compounds from this series, MX-58151, MX-58276, MX-76747, MX-116214,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ed6b8aaf8c9e016d50c3bd489d8eb88
https://pubmed.ncbi.nlm.nih.gov/15542776
https://pubmed.ncbi.nlm.nih.gov/15542776