Late-Stage Glioma Is Associated with Deleterious Alteration of Gut Bacterial Metabolites in Mice

Autor: Aglae Herbreteau, Philippe Aubert, Mikaël Croyal, Philippe Naveilhan, Stéphanie Billon-Crossouard, Michel Neunlist, Yves Delneste, Dominique Couez, Laetitia Aymeric

Publikováno v: Metabolites, Vol 12, Iss 4, p 290 (2022)

Brain-gut axis refers to the bidirectional functional connection between the brain and the gut, which sustains vital functions for vertebrates. This connection also underlies the gastrointestinal (GI) comorbidities associated with brain disorders. Us

Externí odkaz: https://doaj.org/article/27e220ef05c24bfa996665f2d0605537

Age-Related Expression of IFN-lambda1 Versus IFN-I and Beta-Defensins in the Nasopharynx of SARS-CoV-2-Infected Individuals

Autor: Charly Gilbert, Caroline Lefeuvre, Laurence Preisser, Adeline Pivert, Raffaella Soleti, Simon Blanchard, Yves Delneste, Alexandra Ducancelle, Dominique Couez, Pascale Jeannin

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, 2021, Online ahead of print. ⟨10.3389/fimmu.2021.750279⟩
Frontiers in Immunology, Frontiers, 2021, 12, Online ahead of print. ⟨10.3389/fimmu.2021.750279⟩
Frontiers in Immunology, Frontiers, 2021, Online ahead of print. ⟨10.3389/fimmu.2021.750279⟩
Frontiers in Immunology, Vol 12 (2021)

SARS-CoV-2 coronavirus infection induces heterogeneous symptoms, ranging from asymptomatic to lethal forms. Severe forms usually occur in the elderly and/or individuals with comorbidities. Children generally remain asymptomatic to primary infection,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846379c0e218286854a33f1f9f555215
https://www.hal.inserm.fr/inserm-03424094

Neonatal and adult microglia cross-present exogenous antigens

Autor: Yves Delneste, Pascale Jeannin, Ulrich Jarry, Dominique Couez, Hugues Gascan, Céline Beauvillain, Pierre Guermonprez, Mari Scotet, Sabrina Donnou

Publikováno v: Glia. 56:69-77

Some observations have suggested that cells from the central nervous system (CNS) could present exogenous antigens on major histocompatibility complex (MHC) class I molecules to CD8(+) T cells (a process called cross-presentation). Microglia are the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94a48c51fe210345fb11e1eec60800b
https://doi.org/10.1002/glia.20565

Treg depletion followed by intracerebral CpG-ODN injection induce brain tumor rejection

Autor: Yves Delneste, Marie Vincent, Laurent Pineau, Pascale Jeannin, Sabrina Donnou, Isabelle Frémaux, Ulrich Jarry, Dominique Couez

Publikováno v: Journal of Neuroimmunology
Journal of Neuroimmunology, Elsevier, 2014, 267 (1–2), pp.35-42. ⟨10.1016/j.jneuroim.2013.12.005⟩

International audience; Using brain lymphoma model, we demonstrate that immunotherapy combining Treg depletion (using anti-CD25 mAb PC61) followed by intracranial CpG-ODN administration induced tumor rejection in all treated mice and led to the estab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8555f208d96c9376dd6c6615023375b5
https://hal.univ-angers.fr/hal-03389734

Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): Analysis by site directed mutagenesis

Autor: Raymond W. Sweet, Sally D. Lyn, Christopher Eichman, Manjula Reddy, Alemseged Truneh, Daniel Olive, Dominique Couez, Raffick P. Sekaly, Mark R. Hurle, Patricia Ryan

Publikováno v: Molecular Immunology. 33:321-334

CD28, which is a member of the immunoglobulin superfamily of molecules (IgSF), is a homodimer of two polypeptides containing a single V-like domain with short transmembrane and cytoplasmic regions. It serves as a co-signalling molecule for T cell act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d935b659084c85ec130c1fde740dfc0f
https://doi.org/10.1016/0161-5890(95)00077-1