Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Dominique Cottem"'
Autor:
Laurent Azema, Emmanuel Tetaud, Dominique Cottem, Michèle Willson, Frederik Opperdoes, Isabelle Alric, Jacques Périé, Michael P. Barrett, Frédéric Bringaud, Casimir Blonski, Samantha Claustre, Théo Baltz
Publikováno v:
Biochemical Pharmacology. 67:459-467
Glucose metabolism is essential for survival of bloodstream form Trypanosoma brucei subspecies which cause human African trypanosomiasis (sleeping sickness). Hexose analogues may represent good compounds to inhibit glucose metabolism in these cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e3bb5477cb01b2aeb05fc8a9b33c18
https://doi.org/10.1016/j.bcp.2003.09.005
https://doi.org/10.1016/j.bcp.2003.09.005
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2071-2076
Phosphorothioates kill the procyclic form of T. brucei brucei by a non antisense but sequence dependent effect. The alamar Blue(TM) method allowed an easy microscale determination of their antiparasitic effect. The LD50 of the sequences tested was in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea3c087045730b0f3cfef809d46048e6
https://doi.org/10.1016/s0960-894x(97)00362-4
https://doi.org/10.1016/s0960-894x(97)00362-4
Autor:
Dominique Cottem, Frederik Opperdoes
Publikováno v:
FEBS Letters. (1):60-64
Trypanosomatids are protozoan haemoflagellates which are characterized by at least two unique features: the exceptional organization of their mitochondrial DNA, the kinetoplast DNA [ 11; and the presence of microbody-like organelles called glycosomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0ca3a510ef4090c7b86e3d6c44804b