Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Dominique Broccoli"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 463-473 (2019)
Gene delivery vehicles currently in the clinic for treatment of monogenic disorders lack sufficient carrying capacity to efficiently address complex polygenic diseases. Thus, to engineer multifaceted genetic circuits for bioengineering human cells as
Externí odkaz:
https://doaj.org/article/009cbaadce154922baec3f293b814672
Autor:
Dominique Broccoli, David Kipling, Margaret von Mehren, Dina Lev, Sarantis Gagos, Maria Chiourea, Neil Beeharry, Kara Pascarelli, Jay E. Johnson, Marcy A. Mitchell
Supplementary Data from Doxorubicin Resistance in a Novel In vitro Model of Human Pleomorphic Liposarcoma Associated with Alternative Lengthening of Telomeres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09574fcb2046b1b1cab5d83150519a4e
https://doi.org/10.1158/1535-7163.22485696
https://doi.org/10.1158/1535-7163.22485696
Autor:
Dominique Broccoli, David Kipling, Margaret von Mehren, Dina Lev, Sarantis Gagos, Maria Chiourea, Neil Beeharry, Kara Pascarelli, Jay E. Johnson, Marcy A. Mitchell
Soft tissue sarcomas are a diverse set of fatal human tumors where few agents have demonstrable clinical efficacy, with the standard therapeutic combination of doxorubicin and ifosfamide showing only a 25% to 30% response rate in large multi-institut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39051c6209ad8a35ed803e6e14361b3b
https://doi.org/10.1158/1535-7163.c.6532050.v1
https://doi.org/10.1158/1535-7163.c.6532050.v1
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss, Pp 463-473 (2019)
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss, Pp 463-473 (2019)
Gene delivery vehicles currently in the clinic for treatment of monogenic disorders lack sufficient carrying capacity to efficiently address complex polygenic diseases. Thus, to engineer multifaceted genetic circuits for bioengineering human cells as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f72708bdaab3845dddafc32d2ca0c8
http://europepmc.org/articles/PMC6527818
http://europepmc.org/articles/PMC6527818
Publikováno v:
Molecular and Cellular Biology. 41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6c48c39b8f5ddd5d82df8d2497b20f9
https://doi.org/10.1128/mcb.00566-20
https://doi.org/10.1128/mcb.00566-20
Autor:
Kimberly K. Engelman, Joaquina Baranda, Michelle L. Redmond, Philip Twumasi-Ankrah, Elizabeth Ablah, Lisette T. Jacobson, Dominique Broccoli, Wei Tu, Robert B. Hines, Alina Barrett, Tracie C. Collins
Publikováno v:
Journal of the National Comprehensive Cancer Network. 13:51-60
254 Background: We investigated the effect of comorbidity, age, health insurance payer status, and race on the risk of nonadherence with National Comprehensive Cancer Network (NCCN) treatment guidelines for colorectal cancer (CRC) patients. In additi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57de069adc83960565506c63a53fade
https://doi.org/10.6004/jnccn.2015.0008
https://doi.org/10.6004/jnccn.2015.0008
Autor:
David Glyn Kipling, Miles A. Love, Alexander J. Lazar, Dominique Broccoli, Dina Lev, Matthew J. Plantinga, Davis R. Ingram, Mohammed Shaker, Kara Pascarelli, Margaret von Mehren
Publikováno v:
Biomarkers in Cancer, Vol 2014, Iss 6, Pp 1-10 (2014)
Biomarkers in Cancer, Vol 6 (2014)
Biomarkers in Cancer
Biomarkers in Cancer, Vol 6 (2014)
Biomarkers in Cancer
Altered cysteine dioxygenase 1 (CDO1) gene expression has been observed in several cancers but has not yet been investigated in liposarcomas. The aim of this study was to evaluate CDO1 expression in a cohort of liposarcomas and to determine its assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4821b55450eb2d290d314bca3f4850
http://www.la-press.com/differential-expression-of-cysteine-dioxygenase-1-in-complex-karyotype-article-a4153
http://www.la-press.com/differential-expression-of-cysteine-dioxygenase-1-in-complex-karyotype-article-a4153
Publikováno v:
Current Biology. 17:1989-1995
SummaryChromosome ends are maintained by telomere-repeat-binding factors (TRFs) that coordinate DNA end protection with telomere replication [1, 2]. The origin recognition complex (ORC) coordinates bidirectional DNA replication at most chromosomal si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6081e4c66b40a7be3c3d2952d1cf7ea4
https://doi.org/10.1016/j.cub.2007.10.054
https://doi.org/10.1016/j.cub.2007.10.054
Autor:
Dominique Broccoli, Jaclyn Schwalm, Margaret von Mehren, Samuel Litwin, Joseph R. Testa, Jay E. Johnson, Edward J. Gettings, Jianming Pei
Publikováno v:
Cancer Research. 67:9221-9228
Telomere attrition ultimately leads to the activation of protective cellular responses, such as apoptosis or senescence. Impairment of such mechanisms can allow continued proliferation despite the presence of dysfunctional telomeres. Under such condi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60d8f170b18ee18b703d6d76abd72ce
https://doi.org/10.1158/0008-5472.can-07-1133
https://doi.org/10.1158/0008-5472.can-07-1133
Autor:
Dominique Broccoli, Jay E. Johnson
Publikováno v:
Current Opinion in Oncology. 19:377-382
Purpose of review To examine the activation of telomere maintenance in a variety of sarcoma subtypes, and to review the consequences of telomere maintenance with respect to genome stability and tumor progression. Recent findings A hallmark of tumor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a75bfd2ad8ec29461f7311c71a2203
https://doi.org/10.1097/cco.0b013e3281214423
https://doi.org/10.1097/cco.0b013e3281214423