Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Dominique Bonafoux"'
Autor:
Joshua R. Leeman, Joyce T. Coll, Upul K. Bandarage, Derek B. Lowe, Alex Aronov, Christine Memmott, Jacque Zwahlen, Kenneth C. Bonanno, Emanuele Perola, William P. Taylor, Christopher A. Lepre, Dean M. Wilson, Yi Zhou, Rene Rijnbrand, Dominique Bonafoux, Fan Lu, Bhisetti Govinda Rao, Ernst ter Haar, Suganthini Nanthakumar
Publikováno v:
Journal of Medicinal Chemistry. 59:7138-7151
There are currently no treatments for life-threatening infections caused by human polyomaviruses JCV and BKV. We therefore report herein the first crystal structure of the hexameric helicase of JCV large T antigen (apo) and its use to drive the struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e87d9079517681b68b3a5d2fc70a1a
https://doi.org/10.1021/acs.jmedchem.6b00486
https://doi.org/10.1021/acs.jmedchem.6b00486
Autor:
Dominique Bonafoux, Wen-Cherng Lee
Publikováno v:
Expert Opinion on Therapeutic Patents. 19:1759-1769
TGF-beta has been identified as a key factor in the progression of various diseases, in particular cancer and fibrosis. The signaling of TGF-beta can be modulated through three distinct strategies: using antisense nucleotides that block TGF-beta mRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcaf9fbd0d2030f384bdb5bf7a28e630
https://doi.org/10.1517/13543770903397400
https://doi.org/10.1517/13543770903397400
Autor:
Sheri L. Bonar, Adam Libby, Yao Min, Richard Weier, Michael B. Tollefson, Serge G. Wolfson, Michael Clare, Ann M. Donnelly, William E. Mcghee, Dominique Bonafoux, Patrick J. Lennon, Sumathy Mathialagan, Julia A. Guzova, Nandini Kishore, Cindy Sommers, Sharon Rouw, Lori Christine, Catherine S. Tripp
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2870-2875
A series of 21 novel 2-[(aminocarbonyl)amino]-5-acetylenyl-3-thiophenecarboxamides were synthesized and evaluated for the inhibition of IKK-2. In spite of their often modest activity on the enzyme, six selected analogs showed significant inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752b9930690fa8fa16c025496d6ce863
https://doi.org/10.1016/j.bmcl.2005.03.090
https://doi.org/10.1016/j.bmcl.2005.03.090
Publikováno v:
Journal of Fluorine Chemistry. 112:101-108
Novel fluorous biphenols, 5,5′-[ n -C 4 F 9 (CH 2 ) 3 ] 2 -2,2′-biphenol and 5,5′-[ n -C 4 F 9 (CH 2 ) 3 O] 2 -3,3′-di- tert -butyl-2,2′-biphenol, as well as enantiopure BINOLs, ( S )-6,6′-[ n -C 4 F 9 (CH 2 ) 3 ] 2 -BINOL, ( R )-6,6′-[
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d17b08f7617de3942b681254d6e83226
https://doi.org/10.1016/s0022-1139(01)00473-0
https://doi.org/10.1016/s0022-1139(01)00473-0
Autor:
Anthony G. Avent, Peter B. Hitchcock, Michael S. Hill, J. David Smith, Dominique Bonafoux, Colin Eaborn
Publikováno v:
Journal of the Chemical Society, Dalton Transactions. :2183-2190
The lithium compound [LiC(SiMe2CH2PPh2)3] 1, obtained by metallation of the precursor HC(SiMe2CH2PPh2)3I with LiMe, crystallised from benzene as a solvate 1·1.5C6H6 that both in solution and in the solid state has an unusual tricyclic structure, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e11571aa76023adb7c6b3fda54cff431
https://doi.org/10.1039/b002488k
https://doi.org/10.1039/b002488k
Publikováno v:
The Journal of Physical Chemistry A. 103:3388-3401
This photophysical study addresses the general question of how electron transfer in bichromophoric molecules influences the conformational relaxation, which can be toward either more or less π-conjugation. The effects of photoinduced intramolecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0c5917f9798565b9f6d7cbe2c28fd2e
https://doi.org/10.1021/jp9905023
https://doi.org/10.1021/jp9905023
Autor:
Anthony G. Avent, Sushil K. Gupta, Dominique Bonafoux, Colin Eaborn, Peter B. Hitchcock, J. David Smith
Publikováno v:
Journal of the Chemical Society, Dalton Transactions. :831-834
The compound (Ph2PMe2Si)3CH I reacted (i) with [Mo(CO)6] to give cis-[Mo(CO)4{(Ph2PMe2Si)3CH}] 1 in which two phosphine groups are co-ordinated to molybdenum and one is free, and (ii) with LiBu in the presence of N,N,N′,N′-tetramethylethane-1,2-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a22c5b411c8391ffae6da2535fa316b3
https://doi.org/10.1039/a808971j
https://doi.org/10.1039/a808971j
Publikováno v:
Organometallics. 15:2041-2046
Electrochemical trimethylsilylation of mono- and polyhalothiophenes (hal = Cl, Br) has been examined. In order to predict the selectivity of the reaction in accordance with the halogen position on the ring, the reduction potentials of the commerciall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b67b1b98c5b71e11da0d1f7487cda32
https://doi.org/10.1021/om950605h
https://doi.org/10.1021/om950605h
Autor:
Denis Deffieux, Claude Biran, V. Jouikov, Michel Bordeau, M. P. Leger-Lambert, Dominique Bonafoux, Françoise Serein-Spirau, Carole Moreau, C. Duprat
Publikováno v:
Journal de Chimie Physique. 93:591-600
La technique electrochimique a l'anode consommable, en compartiment unique et a intensite constante est une excellente methode preparative pour la creation de liaisons Si-Si et Si-C qui evite l'emploi des metaux alcalins. Comme elle est par ailleurs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06a55a211ac4a0b8201a5d647d1d7654
https://doi.org/10.1051/jcp/1996930591
https://doi.org/10.1051/jcp/1996930591
Publikováno v:
Journal of Organometallic Chemistry. 493:27-32
The 2-pyrrolidone magnesium salt electrogenerated in an undivided cell fitted with a sacrificial magnesium anode allowed the stereoselective synthesis of Z-silyl enol ethers upon deprotonation of enolizable ketones in the presence of a complexing age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6d83f996a9532cf6537d40eadbc7280
https://doi.org/10.1016/0022-328x(94)05368-l
https://doi.org/10.1016/0022-328x(94)05368-l