Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Dominique Bihan"'
Autor:
Nicolas Esquerre, Lilian Basso, Manon Defaye, Fernando A. Vicentini, Nina Cluny, Dominique Bihan, Simon A. Hirota, Alana Schick, Humberto B. Jijon, Ian A. Lewis, Markus B. Geuking, Keith A. Sharkey, Christophe Altier, Yasmin Nasser
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 225-244 (2020)
Background & Aims: Despite achieving endoscopic remission, more than 20% of inflammatory bowel disease patients experience chronic abdominal pain. These patients have increased rectal transient receptor potential vanilloid-1 receptor (TRPV1) expressi
Externí odkaz:
https://doaj.org/article/3b3125c1bc7c426db3bc2c65793c4a10
Autor:
Madeleine Wyss, Kirsty Brown, Carolyn A. Thomson, Mia Koegler, Fernanda Terra, Vina Fan, Francesca Ronchi, Dominique Bihan, Ian Lewis, Markus B. Geuking, Kathy D. McCoy
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Early life exposure to microbes plays an important role in immune system development. Germ-free mice, or mice colonized with a low-diversity microbiota, exhibit high serum IgE levels. An increase in microbial richness, providing it occurs in a critic
Externí odkaz:
https://doaj.org/article/466d0c87b5aa46ee83fef24ddec54f99
Autor:
Wing Ying Chow, Chris J. Forman, Dominique Bihan, Anna M. Puszkarska, Rakesh Rajan, David G. Reid, David A. Slatter, Lucy J. Colwell, David J. Wales, Richard W. Farndale, Melinda J. Duer
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Fibrillar collagens have mechanical and biological roles, providing tissues with both tensile strength and cell binding sites which allow molecular interactions with cell-surface receptors such as integrins. A key question is: how do collage
Externí odkaz:
https://doaj.org/article/eb22423885e3428eb990590955b04686
Autor:
Haiyan Cai, Parvathy Sasikumar, Gemma Little, Dominique Bihan, Samir W. Hamaia, Aiwu Zhou, Jonathan M. Gibbins, Richard W. Farndale
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 983 (2021)
HSP47 (heat shock protein 47) is a collagen-specific molecular chaperone that is essential for procollagen folding and function. Previous studies have shown that HSP47 binding requires a critical Arg residue at the Y position of the (Gly-Xaa-Yaa) rep
Externí odkaz:
https://doaj.org/article/0e2bf6621d8448bc963fdb6e3f364675
Autor:
Mark E. Welland, Richard W. Farndale, Dominique Bihan, Debdulal Roy, Simon J. Attwood, Anna M. C. Simpson, Samir W. Hamaia
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 2, Pp 2832-2845 (2013)
The role of the collagen-platelet interaction is of crucial importance to the haemostatic response during both injury and pathogenesis of the blood vessel wall. Of particular interest is the high affinity interaction of the platelet transmembrane rec
Externí odkaz:
https://doaj.org/article/375505c299cf4b3eb9099620db422c9a
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69833 (2013)
The GFOGER motif in collagens (O denotes hydroxyproline) represents a high-affinity binding site for all collagen-binding integrins. Other GxOGER motifs require integrin activation for maximal binding. The E318W mutant of the integrin α2β1 I domain
Externí odkaz:
https://doaj.org/article/9d1d9f11f659498bb0ecce99ea3115f0
Autor:
Huifang Xu, Dominique Bihan, Francis Chang, Paul H Huang, Richard W Farndale, Birgit Leitinger
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52209 (2012)
The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that bind to and are activated by collagens. Similar to collagen-binding β1 integrins, the DDRs bind to specific motifs within the collagen triple helix. However, these two
Externí odkaz:
https://doaj.org/article/929bc50cb8f14b9989eee9e09454b993
Autor:
Louris J. Feitsma, Harma C. Brondijk, Gavin E. Jarvis, Dominique Hagemans, Dominique Bihan, Natasia Jerah, Marian Versteeg, Richard W. Farndale, Eric G. Huizinga
Publikováno v:
Blood. 139:3087-3098
Glycoprotein VI (GPVI) mediates collagen-induced platelet activation after vascular damage and is an important contributor to the onset of thrombosis, heart attack, and stroke. Animal models of thrombosis have identified GPVI as a promising target fo
Autor:
Fernando A. Vicentini, Jake C. Szamosi, Laura Rossi, Lateece Griffin, Kristoff Nieves, Dominique Bihan, Ian A. Lewis, Quentin J. Pittman, Mark G. Swain, Michael G. Surette, Simon A. Hirota, Keith A. Sharkey
Publikováno v:
Brain, Behavior, and Immunity. 102:266-278
Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract. IBD are associated with a high prevalence of cognitive, behavioural and emotional comorbidities, including anxiety and depression. The link between I
Autor:
Heyu Ni, Bradley W. Doble, Samir W. Hamaia, Peter L. Gross, Subia Tasneem, Catherine P.M. Hayward, Dominique Bihan, D'Andra Parker, Arkadiusz Bonna, Richard W. Farndale, Alexander Leatherdale, David Lillicrap, Yiming Wang
Publikováno v:
Journal of Thrombosis and Haemostasis
Background Multimerin 1 (human: MMRN1, mouse: Mmrn1) is a homopolymeric, adhesive, platelet and endothelial protein that binds to von Willebrand factor and enhances platelet adhesion to fibrillar collagen ex vivo. Objectives To examine the impact of