Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Dominique Ardail"'
Autor:
Anne-Sophie Wozny, Gersende Alphonse, Audrey Cassard, Céline Malésys, Safa Louati, Michael Beuve, Philippe Lalle, Dominique Ardail, Tetsuo Nakajima, Claire Rodriguez-Lafrasse
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Abstract DNA double-strand breaks (DSBs) induced by photon irradiation are the most deleterious damage for cancer cells and their efficient repair may contribute to radioresistance, particularly in hypoxic conditions. Carbon ions (C-ions) act indepen
Externí odkaz:
https://doaj.org/article/b9246a0bfb4742b4a947afac465121a4
Dual 'mAb' HER family blockade in head and neck cancer human cell lines combined with photon therapy
Autor:
Jean-Baptiste Guy, Benoîte Méry, Edouard Ollier, Sophie Espenel, Alexis Vallard, Anne-Sophie Wozny, Stéphanie Simonet, Alexandra Lauret, Priscillia Battiston-Montagne, Dominique Ardail, Gersende Alphonse, Chloé Rancoule, Claire Rodriguez-Lafrasse, Nicolas Magné
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Head and neck cancer stem cells (CSCs) are highly resistant to treatment. When EGFR is overexpressed in head and neck squamous cell carcinoma (HNSCC), HER2 and HER3 are also expressed. The aim of the present study was to investigate the effe
Externí odkaz:
https://doaj.org/article/25541696948a416d88c4361dcc1a3747
Autor:
Riad Ladjohounlou, Safa Louati, Alexandra Lauret, Arnaud Gauthier, Dominique Ardail, Nicolas Magne, Gersende Alphonse, Claire Rodriguez-Lafrasse
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7200 (2020)
We investigated the potential involvement of ceramide-enriched membrane domains in radiation-induced targeted and nontargeted effects using head and neck squamous cell carcinoma with opposite radiosensitivities. In radiosensitive SCC61 cells, the pro
Externí odkaz:
https://doaj.org/article/917626871d40469fbece9ce51b38db21
Autor:
Maïté Hanot, Anthony Boivin, Céline Malésys, Michaël Beuve, Anthony Colliaux, Nicolas Foray, Thierry Douki, Dominique Ardail, Claire Rodriguez-Lafrasse
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e44367 (2012)
Poor local control and tumor escape are of major concern in head-and-neck cancers treated by conventional radiotherapy or hadrontherapy. Reduced glutathione (GSH) is suspected of playing an important role in mechanisms leading to radioresistance, and
Externí odkaz:
https://doaj.org/article/e7aba624e6cd456aa3bdf4366f45073f
Autor:
Anthony Boivin, Maité Hanot, Céline Malesys, Mira Maalouf, Robert Rousson, Claire Rodriguez-Lafrasse, Dominique Ardail
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14558 (2011)
BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is an aggressive and recurrent malignancy owing to intrinsic radioresistance and lack of induction of apoptosis. The major focus of this work was to design a transient glutathione depleting str
Externí odkaz:
https://doaj.org/article/cd60e2c285fb43f2b00785570a3cc95e
Autor:
Nicolas Vial, Sophie Espenel, Claire Rodriguez-Lafrasse, Anne-Sophie Wozny, Dominique Ardail, Nicolas Magné, M.-A. Garcia, Safa Louati, Arnaud Gauthier, Gersende Alphonse, Jean-Baptiste Guy, Céline Malésys
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Journal of Cancer Research and Clinical Oncology, Springer Verlag, 2021, 147 (7), pp.1905-1916. ⟨10.1007/s00432-021-03593-8⟩
Journal of Cancer Research and Clinical Oncology, Springer Verlag, 2021, 147 (7), pp.1905-1916. ⟨10.1007/s00432-021-03593-8⟩
International audience; PurposeThe clinical outcome of head and neck squamous cell carcinoma (HNSCC) remains poor, partly due to the presence of resistant cancer stem cells (CSCs) which are responsible of recurrences. CSCs have low EGFR expression an
Autor:
Anne-Sophie, Wozny, Arnaud, Gauthier, Gersende, Alphonse, Céline, Malésys, Virginie, Varoclier, Michael, Beuve, Delphine, Brichart-Vernos, Nicolas, Magné, Nicolas, Vial, Dominique, Ardail, Tetsuo, Nakajima, Claire, Rodriguez-Lafrasse
Publikováno v:
Cancers
Cancers, MDPI, 2021, 13 (15), pp.3833. ⟨10.3390/cancers13153833⟩
Cancers, Vol 13, Iss 3833, p 3833 (2021)
Volume 13
Issue 15
Cancers, MDPI, 2021, 13 (15), pp.3833. ⟨10.3390/cancers13153833⟩
Cancers, Vol 13, Iss 3833, p 3833 (2021)
Volume 13
Issue 15
Simple Summary Hypoxia-Inducible Factor 1α (HIF-1α), the main regulator of the oxygen homeostasis, promotes cancer cell survival through proliferation, angiogenesis, metastasis and radioresistance. Previously, our group demonstrated that silencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::564d3e24a0a55e6e076ba29f1988467a
https://hal.archives-ouvertes.fr/hal-03326508
https://hal.archives-ouvertes.fr/hal-03326508
Autor:
Arnaud Gauthier, Pierre Philouze, Alexandra Lauret, Gersende Alphonse, Céline Malesys, Dominique Ardail, Léa Payen, Philippe Céruse, Anne-Sophie Wozny, Claire Rodriguez-Lafrasse
Publikováno v:
Journal of Personalized Medicine; Volume 12; Issue 3; Pages: 445
Patients with locally advanced oropharyngeal carcinoma treated with neoadjuvant chemotherapy are reassessed both radiologically and clinically to adapt their treatment after the first cycle. However, some responders show early tumor progression after
Autor:
Safa Louati, Claire Rodriguez-Lafrasse, Arnaud Gauthier, Riad Ladjohounlou, Nicolas Magné, Gersende Alphonse, Alexandra Lauret, Dominique Ardail
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2020, 21 (19), pp.7200. ⟨10.3390/ijms21197200⟩
International Journal of Molecular Sciences, Vol 21, Iss 7200, p 7200 (2020)
Volume 21
Issue 19
International Journal of Molecular Sciences, MDPI, 2020, 21 (19), pp.7200. ⟨10.3390/ijms21197200⟩
International Journal of Molecular Sciences, Vol 21, Iss 7200, p 7200 (2020)
Volume 21
Issue 19
Background: It is now established that radiation can affect membranes of mammalian cells in several ways. Depending on the degree of conditioning and mobility of phospholipidic molecules within the plasma membrane, cells exhibit different degrees of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bb59ba560ad6cfcdd4c8867db47a0b
https://hal.archives-ouvertes.fr/hal-03001763
https://hal.archives-ouvertes.fr/hal-03001763
Autor:
S. Gerbaud, Stéphanie Simonet, Dominique Ardail, O. Tillement, C. Malesys, David Béal, Walid Rachidi, F. Lux, Hussein Fayyad-Kazan, Claire Rodriguez-Lafrasse
Publikováno v:
Journal of Biomedical Nanotechnology
Journal of Biomedical Nanotechnology, American Scientific Publishers, 2020, 16 (1), pp.111-124. ⟨10.1166/jbn.2020.2871⟩
Journal of Biomedical Nanotechnology, 2020, 16 (1), pp.111-124. ⟨10.1166/jbn.2020.2871⟩
Journal of Biomedical Nanotechnology, American Scientific Publishers, 2020, 16 (1), pp.111-124. ⟨10.1166/jbn.2020.2871⟩
Journal of Biomedical Nanotechnology, 2020, 16 (1), pp.111-124. ⟨10.1166/jbn.2020.2871⟩
Radiation therapy is a mainstay in the therapeutic management of Head and Neck Squamous Cell Carcinoma (HNSCC). Despite significant progress in this field, radioresistance still accounts for most treatment failures. Gadolinium-based nanoparticles (GB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f68c7017f2d8f051f4f9e5123fcb0e
https://hal.archives-ouvertes.fr/hal-02476855
https://hal.archives-ouvertes.fr/hal-02476855