Výsledky vyhledávání - "Dominique A. Weber"

Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier

Autor: Dominique A. Weber, Mingli Feng, Charles A. Parkos, Porfirio Nava, Asma Nusrat, Miguel Quiros, Ryuta Kamekura, Hikaru Nishio

Publikováno v: Molecular Biology of the Cell

Proinflammatory cytokines promote desmoglein-2 (Dsg2) ectodomain shedding in intestinal epithelial cells. Epithelial exposure to Dsg2 ectodomains compromises intercellular adhesion while also promoting proliferation. These findings identify mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3eb0f3bafbe5df9aa1449519e72c98
https://doi.org/10.1091/mbc.e15-03-0147

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Neutrophil-derived JAML inhibits repair of intestinal epithelial injury during acute inflammation

Autor: Charles A. Parkos, Rakieb Andargachew, Ronen Sumagin, Philipp Neumann, Jennifer C. Brazil, Oscar Medina-Contreras, Dominique A. Weber, Timothy L. Denning, Asma Nusrat, Giovanna Leoni, Ingrid C. McCall

Publikováno v: Mucosal immunology

Neutrophil transepithelial migration (TEM) during acute inflammation is associated with mucosal injury. Using models of acute mucosal injury in vitro and in vivo, we describe a new mechanism by which neutrophils infiltrating the intestinal mucosa dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944303859b27997c83b395f235ee4ea2
https://doi.org/10.1038/mi.2014.12

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Surfactant Protein D (Sp-D) Binds to Membrane-proximal Domain (D3) of Signal Regulatory Protein α (SIRPα), a Site Distant from Binding Domain of CD47, while Also Binding to Analogous Region on Signal Regulatory Protein β (SIRPβ)

Autor: Alexander Z. Robin, Dominique A. Weber, Oskar Laur, Charles A. Parkos, Winston Y. Lee, Rakieb Andargachew, Dennis R. Voelker, Bénédicte Fournier

Publikováno v: Journal of Biological Chemistry. 287:19386-19398

Signal regulatory protein α (SIRPα), a highly glycosylated type-1 transmembrane protein, is composed of three immunoglobulin-like extracellular loops as well as a cytoplasmic tail containing three classical tyrosine-based inhibitory motifs. Previou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a0a3ada9723050e03dc2cc59721c73
https://doi.org/10.1074/jbc.m111.324533

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The Role of cis Dimerization of Signal Regulatory Protein α (SIRPα) in Binding to CD47

Autor: Charles A. Parkos, Oskar Laur, Ingrid C. McCall, Sean R. Stowell, Rakieb Andargachew, Richard D. Cummings, Winston Y. Lee, Dominique A. Weber

Publikováno v: Journal of Biological Chemistry. 285:37953-37963

Interaction of SIRPα with its ligand, CD47, regulates leukocyte functions, including transmigration, phagocytosis, oxidative burst, and cytokine secretion. Recent progress has provided significant insights into the structural details of the distal I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345b6c3c8b67fcefbfe06450d502f7bf
https://doi.org/10.1074/jbc.m110.180018

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Cutting Edge: HLA-DM Functions through a Mechanism That Does Not Require Specific Conserved Hydrogen Bonds in Class II MHC-Peptide Complexes

Autor: Zemin Zhou, Peter E. Jensen, Dominique A. Weber, Kari A. Callaway

Publikováno v: The Journal of Immunology. 183:4187-4191

HLA-DM catalyzes peptide dissociation and exchange in class II MHC molecules through a mechanism that has been proposed to involve the disruption of specific components of the conserved hydrogen bond network in MHC-peptide complexes. HLA-DR1 molecule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::811900c59cf3677fa16d533414d7e387
https://doi.org/10.4049/jimmunol.0901663

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Qa-1, a Nonclassical Class I Histocompatibility Molecule With Roles in Innate and Adaptive Immunity

Autor: Peter E. Jensen, Dominique A. Weber, Lisa M. Reed-Loisel, Barbara A. Sullivan

Publikováno v: Immunologic Research. 29:081-092

Qa-1, a nonclassical class I histocompatibility molecule expressed in mice, predominantly assembles with a single nonameric peptide, Qdm, derived from the signal sequence of certain class Ia molecules. The Qa-1/Qdm complex is the primary ligand for C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499bda7517849fc94fe3397eebfc45ef
https://doi.org/10.1385/ir:29:1-3:081

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Peptide-Independent Folding and CD8αα Binding by the Nonclassical Class I Molecule, Thymic Leukemia Antigen

Autor: Jan Pohl, Peter E. Jensen, Dominique A. Weber, Jerrod L. Wigal, Antoine Attinger, Ellis L. Reinherz, Mitchell Kronenberg, Hilde Cheroutre, Yi Xiong, Christopher C. Kemball

Publikováno v: The Journal of Immunology. 169:5708-5714

The nonclassical class I molecule, thymic leukemia (TL), has been shown to be expressed on intestinal epithelial cells and to interact with CD8+ intraepithelial T lymphocytes. We generated recombinant soluble TL (T18d) H chains in bacteria as inclusi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6427641cd3bebe53966c1d3e2097e72
https://doi.org/10.4049/jimmunol.169.10.5708

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Positive Selection of a Qa-1-Restricted T Cell Receptor with Specificity for Insulin

Autor: Piotr Kraj, Barbara A. Sullivan, Peter E. Jensen, Leszek Ignatowicz, Dominique A. Weber

Publikováno v: Immunity. 17:95-105

The phenotype and development of T cells from transgenic mice expressing a T cell receptor with specificity for insulin presented by the MHC class Ib molecule Qa-1 b was investigated. Peripheral T cells from the transgenic mice express CD8 and, after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c6895e52413d230880213aad1ab68d
https://doi.org/10.1016/s1074-7613(02)00343-6

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