Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection.

Autor: Sophie Reuse, Miriam Calao, Kabamba Kabeya, Allan Guiguen, Jean-Stéphane Gatot, Vincent Quivy, Caroline Vanhulle, Aurélia Lamine, Dolores Vaira, Dominique Demonte, Valérie Martinelli, Emmanuelle Veithen, Thomas Cherrier, Véronique Avettand, Solène Poutrel, Jacques Piette, Yvan de Launoit, Michel Moutschen, Arsène Burny, Christine Rouzioux, Stéphane De Wit, Georges Herbein, Olivier Rohr, Yves Collette, Olivier Lambotte, Nathan Clumeck, Carine Van Lint

Publikováno v: PLoS ONE, Vol 4, Iss 6, p e6093 (2009)

The persistence of transcriptionally silent but replication-competent HIV-1 reservoirs in Highly Active Anti-Retroviral Therapy (HAART)-treated infected individuals, represents a major hurdle to virus eradication. Activation of HIV-1 gene expression

Externí odkaz: https://doaj.org/article/f1af60741dd14570aa038a4a784fd250

A Defect in Nucleosome Remodeling Prevents IL-12(p35) Gene Transcription in Neonatal Dendritic Cells

Autor: Michel Goldman, Carine Van Lint, Dominique De Wit, Stanislas Goriely, Myriam Libin, Réza Dadkhah, Fabienne Willems, Dominique Demonte

Publikováno v: The Journal of Experimental Medicine

To gain insight into the inability of newborns to mount efficient Th1 responses, we analyzed the molecular basis of defective IL-12(p35) expression in human neonatal monocyte-derived dendritic cells (DCs). Determination of IL-12(p35) pre-mRNA levels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c3cb113bfb0dbc13ac33f9095fba28
http://europepmc.org/articles/PMC2211877

Antiglucocorticoid activity of hepatocyte nuclear factor-6

Autor: Dominique Demonte, Daryl K. Granner, Jean Vandenhaute, Frédéric P. Lemaigre, Richard M. O'Brien, Guy G. Rousseau, Donald K. Scott, Christophe E. Pierreux, John M. Stafford

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, no. 16, p. 8961-8966 (1999)

Glucocorticoids exert their effects on gene transcription through ubiquitous receptors that bind to regulatory sequences present in many genes. These glucocorticoid receptors are present in all cell types, yet glucocorticoid action is controlled in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34c69b9bbd53d41e7b9e8c3ffe6b59b
https://doi.org/10.1073/pnas.96.16.8961

Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection

Autor: Dolores Vaira, Georges Herbein, Stéphane De Wit, Jean-Stéphane Gatot, Sophie Reuse, Solène Poutrel, Yvan de Launoit, Miriam Calao, Olivier Lambotte, Carine Van Lint, Caroline Vanhulle, Thomas Cherrier, Christine Rouzioux, Jacques Piette, Kabamba Kabeya, Vincent Quivy, Olivier Rohr, Michel Moutschen, Dominique Demonte, Aurélia Lamine, Arsène Burny, Véronique Avettand, Nathan Clumeck, Valérie Martinelli, Yves Collette, Emmanuelle Veithen, Allan Guiguen

Publikováno v: PloS one, 4 (6
PLoS ONE
PLoS ONE, Vol 4, Iss 6, p e6093 (2009)
PLoS ONE, Public Library of Science, 2009, 4 (6), pp.e6093. 〈10.1371/journal.pone.0006093〉
PLoS ONE, Public Library of Science, 2009, 4 (6), pp.e6093. ⟨10.1371/journal.pone.0006093⟩

The persistence of transcriptionally silent but replication-competent HIV-1 reservoirs in Highly Active Anti-Retroviral Therapy (HAART)-treated infected individuals, represents a major hurdle to virus eradication. Activation of HIV-1 gene expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f82fc5918a8eda67432f871e8e824cf
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51760

Gene activation and gene silencing: a subtle equilibrium

Autor: Françoise Bex, Dominique Demonte, Ann Dekoninck, Caroline Vanhulle, Carine Van Lint, Claire Calomme, Arsène Burny, Isabelle Lamsoul, Vincent Quivy

Publikováno v: Cloning and stem cells. 6(2)

The genetic make-up of a cell resides entirely in its DNA. Now that the nucleotide sequence of several genomes has been determined, the major challenging problem is to understand how cell differentiation, proliferation or death are controlled. Major

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39bf5f915d07c083a23db778cad09de9
https://pubmed.ncbi.nlm.nih.gov/15268788