CD3+ Macrophages Deliver Proinflammatory Cytokines by a CD3- and Transmembrane TNF-Dependent Pathway and Are Increased at the BCG-Infection Site

Autor: Adriana Rodriguez-Cruz, Dominique Vesin, Lucero Ramon-Luing, Joaquin Zuñiga, Valérie F. J. Quesniaux, Bernhard Ryffel, Ricardo Lascurain, Irene Garcia, Leslie Chávez-Galán

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Macrophages are essential cells of the innate immune response against microbial infections, and they have the ability to adapt under both pro- and anti-inflammatory conditions and develop different functions. A growing body of evidence regarding a no

Externí odkaz: https://doaj.org/article/e96ffc2f9d924820b20e36858725801c

Low Dose BCG Infection as a Model for Macrophage Activation Maintaining Cell Viability

Autor: Leslie Chávez-Galán, Dominique Vesin, Denis Martinvalet, Irene Garcia

Publikováno v: Journal of Immunology Research, Vol 2016 (2016)

Mycobacterium bovis BCG, the current vaccine against tuberculosis, is ingested by macrophages promoting the development of effector functions including cell death and microbicidal mechanisms. Despite accumulating reports on M. tuberculosis, mechanism

Externí odkaz: https://doaj.org/article/ad6c298574f14f8e9d94c1d1904e35c4

Bacillus calmette-guerin infection in NADPH oxidase deficiency: defective mycobacterial sequestration and granuloma formation.

Autor: Christine Deffert, Michela G Schäppi, Jean-Claude Pache, Julien Cachat, Dominique Vesin, Ruth Bisig, Xiaojuan Ma Mulone, Tiina Kelkka, Rikard Holmdahl, Irene Garcia, Maria L Olleros, Karl-Heinz Krause

Publikováno v: PLoS Pathogens, Vol 10, Iss 9, p e1004325 (2014)

Patients with chronic granulomatous disease (CGD) lack generation of reactive oxygen species (ROS) through the phagocyte NADPH oxidase NOX2. CGD is an immune deficiency that leads to frequent infections with certain pathogens; this is well documented

Externí odkaz: https://doaj.org/article/081c7d7b8e9041248ba6eb5f5b151381

Myeloid cell TNFR1 signaling dependent liver injury and inflammation upon BCG infection

Autor: Husnu Uysal, Irene Garcia, Stéphanie Rose, Guillaume Blaser, Leslie Chavez-Galan, Sulayman Benmerzoug, Bernhard Ryffel, Valérie F. J. Quesniaux, Dominique Vesin

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-41629-9⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)

TNF plays a critical role in mononuclear cell recruitment during acute Bacillus Calmette-Guérin (BCG) infection leading to an effective immune response with granuloma formation, but may also cause tissue injury mediated by TNFR1 or TNFR2. Here we in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58080f451be9f64c8ab8a8df645c4d6f
https://hal-cnrs.archives-ouvertes.fr/hal-02126394/document

Tumor Necrosis Factor and Its Receptors Are Crucial to Control Mycobacterium bovis Bacillus Calmette-Guerin Pleural Infection in a Murine Model

Autor: Raphaële Buser-Llinares, Pritha Prasad, Bernhard Ryffel, Dominique Vesin, Guillaume Blaser, Leslie Chavez-Galan, Irene Garcia, Noria Segueni, Valérie F. J. Quesniaux, Jean-Claude Pache

Publikováno v: The American Journal of Pathology, Vol. 186, No 9 (2016) pp. 2364-2377

Tumor necrosis factor (TNF) is crucial to control Mycobacterium tuberculosis infection, which remains a leading cause of morbidity and mortality worldwide. TNF blockade compromises host immunity and may cause reactivation of latent infection, resulti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d18e496e17774ade9cfc59253d249fb
https://archive-ouverte.unige.ch/unige:89090