Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dominique, Struever"'
Autor:
Marc P Hübner, Coralie Martin, Sabine Specht, Marianne Koschel, Bettina Dubben, Stefan J Frohberger, Alexandra Ehrens, Martina Fendler, Dominique Struever, Edward Mitre, Nathaly Vallarino-Lhermitte, Suzanne Gokool, Sara Lustigman, Manfred Schneider, Simon Townson, Achim Hoerauf, Ivan Scandale
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008427 (2020)
A major impediment to eliminate lymphatic filariasis and onchocerciasis is the lack of effective short-course macrofilaricidal drugs or regimens that are proven to be safe for both infections. In this study we tested oxfendazole, an anthelmintic show
Externí odkaz:
https://doaj.org/article/82f0088c9fe348ba9d0ddb5af5d88a13
Autor:
Alexandra Ehrens, Christopher S Lunde, Robert T Jacobs, Dominique Struever, Marianne Koschel, Stefan J Frohberger, Franziska Lenz, Martina Fendler, Joseph D Turner, Stephen A Ward, Mark J Taylor, Yvonne R Freund, Rianna Stefanakis, Eric Easom, Xianfeng Li, Jacob J Plattner, Achim Hoerauf, Marc P Hübner
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007957 (2020)
The elimination of filarial diseases such as onchocerciasis and lymphatic filariasis is hampered by the lack of a macrofilaricidal-adult worm killing-drug. In the present study, we tested the in vivo efficacy of AN11251, a boron-pleuromutilin that ta
Externí odkaz:
https://doaj.org/article/dec6d4c0192a4b7f912f2690a17c0fac
Autor:
Marc P Hübner, Marianne Koschel, Dominique Struever, Venelin Nikolov, Stefan J Frohberger, Alexandra Ehrens, Martina Fendler, Iliana Johannes, Thomas W von Geldern, Kennan Marsh, Joseph D Turner, Mark J Taylor, Stephen A Ward, Kenneth Pfarr, Dale J Kempf, Achim Hoerauf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007636 (2019)
Depletion of Wolbachia endosymbionts of human pathogenic filariae using 4-6 weeks of doxycycline treatment can lead to permanent sterilization and adult filarial death. We investigated the anti-Wolbachia drug candidate ABBV-4083 in the Litomosoides s
Externí odkaz:
https://doaj.org/article/938a56b59b9342c292856f5bada424f0
Autor:
Thomas W von Geldern, Howard E Morton, Rick F Clark, Brian S Brown, Kelly L Johnston, Louise Ford, Sabine Specht, Robert A Carr, Deanne F Stolarik, Junli Ma, Matthew J Rieser, Dominique Struever, Stefan J Frohberger, Marianne Koschel, Alexandra Ehrens, Joseph D Turner, Marc P Hübner, Achim Hoerauf, Mark J Taylor, Stephen A Ward, Kennan Marsh, Dale J Kempf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0007159 (2019)
There is a significant need for improved treatments for onchocerciasis and lymphatic filariasis, diseases caused by filarial worm infection. In particular, an agent able to selectively kill adult worms (macrofilaricide) would be expected to substanti
Externí odkaz:
https://doaj.org/article/68bed1add1a349b9b6bff6345f18be14
Autor:
Sara Lustigman, Edward Mitre, Marc P. Hübner, Sabine Specht, Marianne Koschel, Alexandra Ehrens, Manfred Schneider, Martina Fendler, Stefan J. Frohberger, Nathaly Vallarino-Lhermitte, Bettina Dubben, Simon Townson, Achim Hoerauf, Ivan Scandale, Coralie Martin, Suzanne Gokool, Dominique Struever
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008427 (2020)
PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008427 (2020)
A major impediment to eliminate lymphatic filariasis and onchocerciasis is the lack of effective short-course macrofilaricidal drugs or regimens that are proven to be safe for both infections. In this study we tested oxfendazole, an anthelmintic show
Autor:
Hanna T. Sjoberg, Mark J. Taylor, Bertrand L. Ndzeshang, William J. Sullivan, Mitchell V. Hull, Franziska Lenz, Wen Xiong, Case W. McNamara, Haelly M. Metuge, Nicolas Pionnier, Kelli Kuhen, Stefan J. Frohberger, Ashley K. Woods, Samuel Wanji, Laura Chappell, Frédéric Landmann, Xin-Jie Chu, Joseph D. Turner, Tayong Dizzle Bita Kwenti, Alain Debec, Achim Hoerauf, Bettina Dubben, Jason Roland, Matt S. Tremblay, Narcisse Victor T. Gandjui, Peter G. Schultz, Arnab K. Chatterjee, Jason Olejniczak, Baiyuan Yang, Patrick W. N. Chounna, Fanny Fri Fombad, Andrew Steven, Roohollah Kazem Shiroodi, Dominique Struever, Malina A. Bakowski, Sean B. Joseph, Renhe Liu, H. Michael Petrassi, Kerstin Mae Gagaring, John Archer, Emma A Murphy, Pamela M. White, Desmond N. Akumtoh, Valerine C. Chunda, Abdel Jelil Njouendou, Marc P. Hübner, Hui Guo, Alexandra Ehrens
Publikováno v:
Science Translational Medicine
Science Translational Medicine, American Association for the Advancement of Science, 2019, 11 (491), pp.eaav3523. ⟨10.1126/scitranslmed.aav3523⟩
Science Translational Medicine, American Association for the Advancement of Science, 2019, 11 (491), pp.eaav3523. ⟨10.1126/scitranslmed.aav3523⟩
Parasitic filarial nematodes cause debilitating infections in people in resource-limited countries. A clinically validated approach to eliminating worms uses a 4- to 6-week course of doxycycline that targetsWolbachia, a bacterial endosymbiont require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b7dd2acbde369889842c0450e10664
https://hal.archives-ouvertes.fr/hal-02365965
https://hal.archives-ouvertes.fr/hal-02365965
In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae
Autor:
Mark J. Taylor, Marianne Koschel, Stefan J. Frohberger, Thomas W. von Geldern, Kennan C. Marsh, Joseph D. Turner, Achim Hoerauf, Venelin Nikolov, Dominique Struever, Marc P. Hübner, Kenneth Pfarr, Alexandra Ehrens, Martina Fendler, Iliana Johannes, Stephen A. Ward, Dale J. Kempf
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007636 (2019)
PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007636 (2019)
Depletion of Wolbachia endosymbionts of human pathogenic filariae using 4–6 weeks of doxycycline treatment can lead to permanent sterilization and adult filarial death. We investigated the anti-Wolbachia drug candidate ABBV-4083 in the Litomosoides
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis
Autor:
Paul M. O'Neill, Edward W. Tate, W. David Hong, Adam P. Roberts, Marc P. Hübner, Peter J. H. Webborn, Mark J. Taylor, Alexandra Ehrens, Stefan J. Frohberger, Dominique Struever, John Archer, Farid Benayoud, Joseph D. Turner, Rachel H. Clare, Achim Hoerauf, Stefan Kavanagh, Fabian Gusovsky, Andrew Steven, Neil G. Berry, Kelly L. Johnston, Ghaith Aljayyoussi, Andrew Cassidy, Remigiusz A. Serwa, Suet C. Leung, Janet Hemingway, Alasdair T. M. Hubbard, Gemma L. Nixon, Amy Siu, Stephen A. Ward, Emma A Murphy, Louise Ford, Li Qie, Motohiro Shiotani, Darren A. N. Cook
Publikováno v:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼157 million people and inflict severe disability. Both diseases are caused by parasitic filarial nematodes with elimination efforts constrained by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d971c5d526af7ac9de5fb24d20f2893d
Autor:
W David, Hong, Farid, Benayoud, Gemma L, Nixon, Louise, Ford, Kelly L, Johnston, Rachel H, Clare, Andrew, Cassidy, Darren A N, Cook, Amy, Siu, Motohiro, Shiotani, Peter J H, Webborn, Stefan, Kavanagh, Ghaith, Aljayyoussi, Emma, Murphy, Andrew, Steven, John, Archer, Dominique, Struever, Stefan J, Frohberger, Alexandra, Ehrens, Marc P, Hübner, Achim, Hoerauf, Adam P, Roberts, Alasdair T M, Hubbard, Edward W, Tate, Remigiusz A, Serwa, Suet C, Leung, Li, Qie, Neil G, Berry, Fabian, Gusovsky, Janet, Hemingway, Joseph D, Turner, Mark J, Taylor, Stephen A, Ward, Paul M, O'Neill
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis) are neglected tropical diseases that cause severe disability and affect more than 157 million people globally. Current control efforts are hindered by the lack of
Autor:
Christopher S. Lunde, Martina Fendler, Xianfeng Li, Joseph D. Turner, Mark J. Taylor, Marianne Koschel, Marc P. Hübner, Alexandra Ehrens, Dominique Struever, Robert T. Jacobs, Franziska Lenz, Stefan J. Frohberger, Achim Hoerauf, Eric E. Easom, Yvonne Freund, Stephen A. Ward, Jacob J. Plattner, Rianna Stefanakis
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007957 (2020)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
The elimination of filarial diseases such as onchocerciasis and lymphatic filariasis is hampered by the lack of a macrofilaricidal–adult worm killing–drug. In the present study, we tested the in vivo efficacy of AN11251, a boron-pleuromutilin tha