Zobrazeno 1 - 10
of 237
pro vyhledávání: '"Dominique, Massotte"'
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Abstract The δ-opioid receptor (DOP) is an attractive pharmacological target due to its potent analgesic, anxiolytic and anti-depressant activity in chronic pain models. However, some but not all selective DOP agonists also produce severe adverse ef
Externí odkaz:
https://doaj.org/article/7a9660019a0841789184816179841e8c
Autor:
Jesse J. DiCello, Simona E. Carbone, Ayame Saito, Pradeep Rajasekhar, Rhian A. Ceredig, Vi Pham, Celine Valant, Arthur Christopoulos, Nicholas A. Veldhuis, Meritxell Canals, Dominique Massotte, Daniel P. Poole
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 465-483 (2020)
Background & Aims: Functional interactions between the mu opioid receptor (MOR) and delta opioid receptor (DOR) represent a potential target for novel analgesics and may drive the effects of the clinically approved drug eluxadoline for the treatment
Externí odkaz:
https://doaj.org/article/8f8f779f1b2f4f4d943c4c44b64c0667
Autor:
Rhian Alice Ceredig, Florian Pierre, Stéphane Doridot, Unai Alduntzin, Pierre Hener, Eric Salvat, Ipek Yalcin, Claire Gaveriaux-Ruff, Michel Barrot, Dominique Massotte
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2020)
Neuropathic pain is a challenging condition for which current therapies often remain unsatisfactory. Chronic administration of β2 adrenergic agonists, including formoterol currently used to treat asthma and chronic obstructive pulmonary disease, all
Externí odkaz:
https://doaj.org/article/44b20706d5024c649e67eaa6f7b4ae52
Publikováno v:
Toxins, Vol 14, Iss 1, p 48 (2022)
Chronic exposure to the mycotoxin deoxynivalenol (DON) from grain-based food and feed affects human and animal health. Known consequences include entereopathogenic and immunotoxic defects; however, the neurotoxic potential of DON has only come into f
Externí odkaz:
https://doaj.org/article/7a4d0ca54cbc4bea9fa9d66ea285fc95
Autor:
Soledad Domínguez, Christophe Clément Rey, Ludivine Therreau, Aurélien Fanton, Dominique Massotte, Laure Verret, Rebecca Ann Piskorowski, Vivien Chevaleyre
Publikováno v:
Cell Reports, Vol 29, Iss 5, Pp 1099-1112.e4 (2019)
Summary: Adolescence is a vulnerable period characterized by major cognitive changes. The mechanisms underlying the emergence of new cognitive functions are poorly understood. We find that a long-term depression of inhibitory transmission (iLTD) from
Externí odkaz:
https://doaj.org/article/3be3a5e6434a46c3a2c9d757a0854967
Publikováno v:
Frontiers in Psychiatry, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/f6ef1df7cc49401c96fcdc6255e7283d
Autor:
Tando Maduna, Emilie Audouard, Doulaye Dembélé, Nejma Mouzaoui, David Reiss, Dominique Massotte, Claire Gaveriaux-Ruff
Publikováno v:
Frontiers in Psychiatry, Vol 9 (2019)
Background: Microglia activation contributes to chronic pain and to the adverse effects of opiate use such as analgesic tolerance and opioid-induced hyperalgesia. Both mu opioid receptor (MOR) encoded by Oprm1/OPRM1 gene and toll like receptor 4 (TLR
Externí odkaz:
https://doaj.org/article/b24507d049cf4e5890f4f15834ed9145
Publikováno v:
Molecules, Vol 25, Iss 19, p 4493 (2020)
Increasing evidence indicates that native mu and delta opioid receptors can associate to form heteromers in discrete brain neuronal circuits. However, little is known about their signaling and trafficking. Using double-fluorescent knock-in mice, we i
Externí odkaz:
https://doaj.org/article/f7bf6db1102249e18f4b59081df1dd4c
Publikováno v:
Frontiers in Psychiatry, Vol 9 (2018)
Opioids are powerful analgesics but the clinical utility of these compounds is reduced by aversive outcomes, including the development of affective and substance use disorders. Opioid systems do not function in isolation so understanding how these in
Externí odkaz:
https://doaj.org/article/0ce1cf9bd4fd4c18baef26839086a4df
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Mu opioid receptors modulate a large number of physiological functions. They are in particular involved in the control of pain perception and reward properties. They are also the primary molecular target of opioid drugs and mediate their beneficial a
Externí odkaz:
https://doaj.org/article/55aee7c4ab95435ea1250d1b97406be5