Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Dominique, Forbes"'
Publikováno v:
Cancer Management and Research. 12:7715-7724
Background Mouse double minute 2 (MDM2) is an E3 ubiquitin ligase that is over-expressed in many cancers and regulates target proteins through ubiquitination. Full-length MDM2 (MDM2-FL) is best known for targeting wild-type p53 for degradation by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08d1db260dd58043322d2e0c31ec7eef
https://doi.org/10.2147/cmar.s260943
https://doi.org/10.2147/cmar.s260943
Autor:
Rusia Lee, Viola Ellison, Gu Xiao, Dominique Forbes, Pam Leybengrub, Alexandra Kern, Falande Alexandre, George Annor, Jill Bargonetti
Publikováno v:
Cancer Research. 82:2437-2437
Human breast cancers often overexpress MDM family proteins MDM2 and MDMX(MDM4). MDM2 is an E3 ubiquitin ligase and MDMX is an E4 that promotes ubiquitination of MDM2 targets (however this is an understudied area). The Cancer Genome Atlas (TCGA) shows
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fdaee1c51bc11c3bebe83c2f73833a7
https://doi.org/10.1158/1538-7445.am2022-2437
https://doi.org/10.1158/1538-7445.am2022-2437
Publikováno v:
Cancer Management and Research
Background Mouse double minute 2 (MDM2) is an E3 ubiquitin ligase that is over-expressed in many cancers and regulates target proteins through ubiquitination. Full-length MDM2 (MDM2-FL) is best known for targeting wild-type p53 for degradation by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41436b8e7d672bca750aea46ea842405
https://pubmed.ncbi.nlm.nih.gov/32904724
https://pubmed.ncbi.nlm.nih.gov/32904724