Výsledky vyhledávání - "Dominique, Bluteau"

Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia

Autor: Marie Sebert, Stéphanie Gachet, Thierry Leblanc, Alix Rousseau, Olivier Bluteau, Rathana Kim, Raouf Ben Abdelali, Flore Sicre de Fontbrune, Loïc Maillard, Carèle Fedronie, Valentine Murigneux, Léa Bellenger, Naira Naouar, Samuel Quentin, Lucie Hernandez, Nadia Vasquez, Mélanie Da Costa, Pedro H. Prata, Lise Larcher, Marie de Tersant, Matthieu Duchmann, Anna Raimbault, Franck Trimoreau, Odile Fenneteau, Wendy Cuccuini, Nathalie Gachard, Nathalie Auger, Giulia Tueur, Maud Blanluet, Claude Gazin, Michèle Souyri, Francina Langa Vives, Aaron Mendez-Bermudez, Hélène Lapillonne, Etienne Lengline, Emmanuel Raffoux, Pierre Fenaux, Lionel Adès, Edouard Forcade, Charlotte Jubert, Carine Domenech, Marion Strullu, Bénédicte Bruno, Nimrod Buchbinder, Caroline Thomas, Arnaud Petit, Guy Leverger, Gérard Michel, Marina Cavazzana, Eliane Gluckman, Yves Bertrand, Nicolas Boissel, André Baruchel, Jean-Hugues Dalle, Emmanuelle Clappier, Eric Gilson, Ludovic Deriano, Sylvie Chevret, François Sigaux, Gérard Socié, Dominique Stoppa-Lyonnet, Hugues de Thé, Christophe Antoniewski, Dominique Bluteau, Régis Peffault de Latour, Jean Soulier

Publikováno v: Cell Stem Cell
Cell Stem Cell, 2023, 30 (2), pp.153-170.e9. ⟨10.1016/j.stem.2023.01.006⟩

International audience; Fanconi anemia (FA) patients experience chromosome instability, yielding hematopoietic stem/progenitor cell (HSPC) exhaustion and predisposition to poor-prognosis myeloid leukemia. Based on a longitudinal cohort of 335 patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c04c73d99e0cccd9d3216befe9e7cea
https://hal.science/hal-04157812

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Akademický článek

p19INK4d Controls Hematopoietic Stem Cells in a Cell-Autonomous Manner during Genotoxic Stress and through the Microenvironment during Aging

Autor: Morgane Hilpert, Céline Legrand, Dominique Bluteau, Natalie Balayn, Aline Betems, Olivier Bluteau, Jean-Luc Villeval, Fawzia Louache, Patrick Gonin, Najet Debili, Isabelle Plo, William Vainchenker, Laure Gilles, Hana Raslova

Publikováno v: Stem Cell Reports, Vol 3, Iss 6, Pp 1085-1102 (2014)

Hematopoietic stem cells (HSCs) are characterized by the capacity for self-renewal and the ability to reconstitute the entire hematopoietic compartment. Thrombopoietin maintains adult HSCs in a quiescent state through the induction of cell cycle inhi

Externí odkaz: https://doaj.org/article/8d362dff690f402983d266a8c9926945

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Clonal Hematopoiesis Driven By MDM4 Amplification Defines a Canonical Route Towards Secondary MDS/AML in Fanconi Anemia Patients

Publikováno v: Blood
Blood, 2021, 138 (Supplement 1), pp.860-860. ⟨10.1182/blood-2021-147811⟩

Introduction Fanconi anemia (FA) is the most frequent inherited DNA-repair disease in human, driving hematopoietic stem cell (HSC) failure in children and a major predisposition to poor-prognosis myelodysplastic syndrome (MDS) and acute leukemia (AML

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3b42f5733964e337e93af142d29eb9
https://doi.org/10.1182/blood-2021-147811

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Downregulation of TREM-like transcript-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia

Autor: Ana C, Glembotsky, Dominika, Sliwa, Dominique, Bluteau, Nathalie, Balayn, Cecilia P, Marin Oyarzún, Anna, Raimbault, Marie, Bordas, Nathalie, Droin, Iryna, Pirozhkova, Valance, Washington, Nora P, Goette, Rosana F, Marta, Rémi, Favier, Hana, Raslova, Paula G, Heller

Publikováno v: Haematologica

Germline RUNX1 mutations lead to thrombocytopenia and platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia (AML). Multiple aspects of platelet function are impaired in these patients, associated with al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5bd6239e7b6d7a171822e3f16af9958a
https://pubmed.ncbi.nlm.nih.gov/30545930

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p19INK4d Controls Hematopoietic Stem Cells in a Cell-Autonomous Manner during Genotoxic Stress and through the Microenvironment during Aging

Autor: Patrick Gonin, Jean-Luc Villeval, Dominique Bluteau, Olivier Bluteau, Laure Gilles, Hana Raslova, Natalie Balayn, Céline Legrand, Najet Debili, Isabelle Plo, Fawzia Louache, Morgane Hilpert, Aline Betems, William Vainchenker

Publikováno v: Stem Cell Reports
Stem Cell Reports, Vol 3, Iss 6, Pp 1085-1102 (2014)

Summary Hematopoietic stem cells (HSCs) are characterized by the capacity for self-renewal and the ability to reconstitute the entire hematopoietic compartment. Thrombopoietin maintains adult HSCs in a quiescent state through the induction of cell cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef291110d8631cc730fe6ee39cfbd0e
https://doi.org/10.1016/j.stemcr.2014.10.005

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Biallelic truncating FANCM mutations cause early-onset cancer but not Fanconi anemia

Autor: Massimo Bogliolo, Jean Soulier, Jordi Surrallés, Nadia Vasquez, Thierry Leblanc, Dominique Stoppa-Lyonnet, Roser Pujol, Dominique Bluteau, James Lespinasse, Catherine Dubois d'Enghien

Publikováno v: Genetics in medicine : official journal of the American College of Medical Genetics. 20(4)

PurposeMutations in genes involved in Fanconi anemia (FA)/BRCA DNA repair pathway cause cancer susceptibility diseases including familial breast cancer and Fanconi anemia (FA). A single FA patient with biallelic FANCM mutations was reported in 2005 b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e669dd75931aa65edaaae96482414705
https://pubmed.ncbi.nlm.nih.gov/28837157

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