Výsledky vyhledávání - "Dominika Rittler"

Akademický článek

Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

Autor: Eszter Molnár, Dominika Rittler, Marcell Baranyi, Michael Grusch, Walter Berger, Balázs Döme, József Tóvári, Clemens Aigner, József Tímár, Tamás Garay, Balázs Hegedűs

Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018)

Abstract Background Currently, there are no available targeted therapy options for non-V600 BRAF mutated tumors. The aim of this study was to investigate the effects of RAF and MEK concurrent inhibition on tumor growth, migration, signaling and apopt

Externí odkaz: https://doaj.org/article/eb03ce1342774897b38a56b7e9cee8a9

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HDAC Inhibition Induces PD-L1 Expression in a Novel Anaplastic Thyroid Cancer Cell Line

Autor: Luca Hegedűs, Dominika Rittler, Sarah Theurer, Agnes Bankfalvi, Ildikó Kovács, Thomas Hager, Thomas Herold, Stavros Kalbourtzis, Clemens Aigner, Kurt Werner Schmid, Paul Stockhammer, Balazs Dome, Tamás Garay, Balázs Hegedűs, Dagmar Führer

Publikováno v: Pathology Oncology Research

While papillary thyroid cancer (PTC) has largely favorable prognosis, anaplastic thyroid cancer (ATC) is a rare but extremely aggressive malignancy with grim clinical outcome. Even though new therapeutic options are emerging for ATC, additional precl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db39573d4156e29e37b30ec5f01b301
https://doi.org/10.1007/s12253-020-00834-y

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Next Generation Lipophilic Bisphosphonate Shows Antitumor Effect in Colorectal Cancer In Vitro and In Vivo

Autor: Imre Varga, Tamás Garay, Clemens Aigner, Balázs Hegedűs, Marcell Baranyi, Afrodíté Németh, Magdolna Dank, Senji Shirasawa, Luca Hegedűs, Eszter Molnár, Dominika Rittler, István Jalsovszky, József Tóvári, József Tímár

Publikováno v: Pathology & Oncology Research. 26:1957-1969

Bisphosphonates, despite proven antitumor effect in vitro in many tumor types, are currently used only for treatment of osteoporosis and bone metastasis. Colorectal cancer is the third most commonly diagnosed type of cancer and lacks targeted therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315c3b93b30143ecc5ebb30ff3836ec5
https://doi.org/10.1007/s12253-019-00789-9

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HDAC Inhibition Induces Cell Cycle Arrest and Mesenchymal-Epithelial Transition in a Novel Pleural-Effusion Derived Uterine Carcinosarcoma Cell Line

Autor: Paul, Stockhammer, Özlem, Okumus, Luca, Hegedus, Dominika, Rittler, Till, Ploenes, Thomas, Herold, Stavros, Kalbourtzis, Agnes, Bankfalvi, Antje, Sucker, Rainer, Kimmig, Clemens, Aigner, Balazs, Hegedus

Publikováno v: Pathology and Oncology Research

Objective: Uterine carcinosarcoma (UCS) is a rare but highly aggressive malignancy with biphasic growth pattern. This morphology can be attributed to epithelial-mesenchymal transition (EMT) that often associates with tumor invasion and metastasis. Ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ace9b2d44fae1aab818660523fc4d84e
https://pubmed.ncbi.nlm.nih.gov/34257602

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Horizontal Combination of MEK and PI3K/mTOR Inhibition in BRAF Mutant Tumor Cells with or without Concomitant PI3K Pathway Mutations

Autor: Dominika Rittler, Eszter Molnár, Marcell Baranyi, Tamás Garay, Luca Hegedűs, Clemens Aigner, József Tóvári, József Tímár, Balázs Hegedűs

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 20
International Journal of Molecular Sciences, Vol 21, Iss 7649, p 7649 (2020)

The RAS/RAF and PI3K/Akt pathways play a key regulatory role in cancer and are often hit by oncogenic mutations. Despite molecular targeting, the long-term success of monotherapy is often hampered by de novo or acquired resistance. In the case of con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::188c3efa03a1ffcd5f4fdb19c406d886
https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00073734/Ritter_et_al_ijms-21-07649.pdf

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[Impact of prenylation inhibition on RAS mutant tumors in preclinical studies]

Autor: Marcell, Baranyi, Eszter, Molnár, Dominika, Rittler, Balázs, Hegedûs, József, Tímár

Publikováno v: Magyar onkologia. 63(4)

Oncogenic mutation of RAS occurs in 20-25% of all malignancies. Our research group have examined inhibition of RAS prenylation on RAS wild type and RAS mutated melanoma, colorectal cancer and lung adenocarcinoma cell lines. Effects of clinically appr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::be2ca6f59fd6ae64a1202ec2e6f21959
https://pubmed.ncbi.nlm.nih.gov/31821387

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Long-Term Vemurafenib Exposure Induced Alterations of Cell Phenotypes in Melanoma : Increased Cell Migration and Its Association with EGFR Expression

Autor: Marco Donia, Marcell Baranyi, Dominika Rittler, Walter Berger, Eszter Molnár, József Tímár, Balázs Hegedűs, Michael Grusch, Tamás Garay

Publikováno v: Molnár, E, Garay, T, Donia, M, Baranyi, M, Rittler, D, Berger, W, Tímár, J, Grusch, M & Hegedűs, B 2019, ' Long-Term Vemurafenib Exposure Induced Alterations of Cell Phenotypes in Melanoma : Increased Cell Migration and Its Association with EGFR Expression ', International Journal of Molecular Sciences, vol. 20, no. 18, 4484 . https://doi.org/10.3390/ijms20184484
International Journal of Molecular Sciences
Volume 20
Issue 18
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4484 (2019)

Acquired resistance during BRAF inhibitor therapy remains a major challenge for melanoma treatment. Accordingly, we evaluated the phenotypical and molecular changes of isogeneic human V600E BRAF-mutant melanoma cell line pairs pre- and post-treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c940f3bdc729af27e2d11c9360835c4c
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85072142127

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