Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1

Autor: Daniel T. Utzschneider, Arnaud Delpoux, Dominik Wieland, Xin Huang, Chen-Yen Lai, Maike Hofmann, Robert Thimme, Stephen M. Hedrick

Publikováno v: Cell Reports, Vol 22, Iss 13, Pp 3454-3467 (2018)

Summary: Immunity following an acutely resolved infection or the long-term equipoise of chronic viral infections often depends on the maintenance of antigen-specific CD8+ T cells, yet the ongoing transcriptional requirements of these cells remain unc

Externí odkaz: https://doaj.org/article/8d00be06d5784495b315b6323a25c4e9

Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection

Autor: Oezlem Sogukpinar, Ralf Bartenschlager, Emma Gostick, Sagar, Dominik Wieland, Christian Conrad, Dominic Grün, Janine Kemming, Katharina Jechow, Bertram Bengsch, David Price, Naveed Ishaque, Robert Thimme, Zuguang Gu, Sian Llewellyn-Lacey, Christoph Neumann-Haefelin, Roland Eils, Maike Hofmann, Florian Emmerich, Nina Hensel, Tobias Boettler

Publikováno v: Nature Immunology

In chronic hepatitis C virus (HCV) infection, exhausted HCV-specific CD8+ T cells comprise memory-like and terminally exhausted subsets. However, little is known about the molecular profile and fate of these two subsets after the elimination of chron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb24cc2e789be24c40a0bea057853c9
https://doi.org/10.1038/s41590-020-00817-w

Follicular T helper cells shape the HCV-specific CD4+ T cell repertoire after virus elimination

Autor: Maike Smits, Robert Thimme, Dominik Wieland, Catherine Fauvelle, Katharina Jechow, Christoph Neumann-Haefelin, Naveed Ishaque, Katharina Zoldan, Maike Hofmann, Zuguang Gu, Bertram Bengsch, Thomas F. Baumert, Roland Eils, Florian Emmerich, Tobias Boettler, Christian Conrad

Publikováno v: The Journal of clinical investigation
The Journal of clinical investigation, 2020, 130 (2), ⟨10.1172/JCI129642⟩
J Clin Invest
Journal of Clinical Investigation

BACKGROUNDChronic hepatitis C virus (HCV) infection is characterized by a severe impairment of HCV-specific CD4+ T cell help that is driven by chronic antigen stimulation. We aimed to study the fate of HCV-specific CD4+ T cells after virus eliminatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60c511c951a5df231dd4c4df77b4508
https://hal.archives-ouvertes.fr/hal-02917275

Memory vs memory-like: The different facets of CD8+T-cell memory in HCV infection

Autor: Hanspeter Pircher, Dominik Wieland, Robert Thimme, Maike Hofmann

Publikováno v: Immunological Reviews. 283:232-237

Memory CD8+ T cells are essential in orchestrating protection from re-infection. Hallmarks of virus-specific memory CD8+ T cells are the capacity to mount recall responses with rapid induction of effector cell function and antigen-independent surviva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b4390d8f136b0c67aea6c8d2b03401c
https://doi.org/10.1111/imr.12642

TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation

Autor: Dietmar Zehn, Dominik Wieland, A Schuch, Janine Kemming, Percy A. Knolle, Christoph Neumann-Haefelin, Werner Held, Florian Emmerich, Robert Thimme, Maike Hofmann

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature communications, vol. 8, pp. 15050

Differentiation and fate of virus-specific CD8+ T cells after cessation of chronic antigen stimulation is unclear. Here we show that a TCF1+CD127+PD1+ hepatitis C virus (HCV)-specific CD8+ T-cell subset exists in chronically infected patients with ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f37047bbfb0bf65c5ae4830d2e0bf5c
https://doaj.org/article/9297f10505a14ae8978a8c449887da65