Influenza vaccination of cancer patients during PD-1 blockade induces serological protection but may raise the risk for immune-related adverse events

Autor: Heinz Läubli, Catharina Balmelli, Lukas Kaufmann, Michal Stanczak, Mohammedyaseen Syedbasha, Dominik Vogt, Astrid Hertig, Beat Müller, Oliver Gautschi, Frank Stenner, Alfred Zippelius, Adrian Egli, Sacha I. Rothschild

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-10 (2018)

Abstract Background Immune checkpoint inhibiting antibodies were introduced into routine clinical practice for cancer patients. Checkpoint blockade has led to durable remissions in some patients, but may also induce immune-related adverse events (irA

Externí odkaz: https://doaj.org/article/c6e9658ca84b46c08bcef4f012c09d41

Association of Host Factors With Antibody Response to Seasonal Influenza Vaccination in Allogeneic Hematopoietic Stem Cell Transplant Patients

Autor: Antonia M.S. Müller, Hans-Michael Kaltenbach, Dominik Vogt, Nathan Cantoni, Jörg Halter, J. Linnik, Georg Stussi, Jörg Stelling, Mohammedyaseen Syedbasha, Urs Schanz, Maja Weisser, Thomas Pabst, Yvonne Hollenstein, Sabine Ruosch-Girsberger, Lukas Kaufmann, Adrian Egli

Publikováno v: The Journal of Infectious Diseases, 225 (8)
Linnik, Janina; Syedbasha, Mohammedyaseen; Kaltenbach, Hans-Michael; Vogt, Dominik; Hollenstein, Yvonne; Kaufmann, Lukas; Cantoni, Nathan; Ruosch-Girsberger, Sabine; Müller, Antonia M S; Schanz, Urs; Pabst, Thomas; Stüssi, Georg; Weisser, Maja; Halter, Jörg; Stelling, Jörg; Egli, Adrian (2022). Association of Host Factors With Antibody Response to Seasonal Influenza Vaccination in Allogeneic Hematopoietic Stem Cell Transplant Patients. The journal of infectious diseases, 225(8), pp. 1482-1493. Oxford University Press 10.1093/infdis/jiab391

Background Influenza vaccination efficacy is reduced after hematopoietic stem cell transplantation (HSCT) and patient factors determining vaccination outcomes are still poorly understood. Methods We investigated the antibody response to seasonal infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68ed71afad0f52ef1bc95ebe5f0f662

Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles

Autor: Carlo Angioni, Bettina Hofmann, Felix F Lillich, Manfred Schubert-Zsilavecz, Jessica Roos, Stefano Woltersdorf, Holger Stark, Michael Rühl, Mario Wurglics, Ann-Kathrin Häfner, Dieter Steinhilber, Simon B.M. Kretschmer, Dominik Vogt, Michael Karas, Astrid Kaiser, Gerd Geisslinger, Isabelle V. Maucher

Publikováno v: Biochemical Pharmacology. 123:52-62

5-Lipoxygenase (5-LO, EC1.13.11.34) has been implicated in the pathogenesis of inflammatory and immune diseases. Recently, aminothiazole comprising inhibitors have been discovered for this valuable target. Yet, the molecular mode of action of this cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e0eced889b420814620a56997b5620
https://doi.org/10.1016/j.bcp.2016.09.021

Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism

Autor: Dominik Vogt, Holger Stark

Publikováno v: Medicinal Research Reviews. 37:3-51

During the last two decades the study of the sphingolipid anabolic, catabolic, and signaling pathways has attracted enormous interest. Especially the introduction of fingolimod into market as first p.o. therapeutic for the treatment of multiple scler

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5ab60e95c8b1ecaa372c5ff979abaab
https://doi.org/10.1002/med.21402

An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers

Autor: Lukas Kaufmann, Mohammedyaseen Syedbasha, Dominik Vogt, Julia Hartmann, Adrian Egli, J. Linnik, Yvonne Hollenstein

Publikováno v: Journal of visualized experiments : JoVE. (130)

Antibody titers are commonly used as surrogate markers for serological protection against influenza and other pathogens. Detailed knowledge of antibody production pre- and post-vaccination is required to understand vaccine-induced immunity. This arti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da583cf18630279c3cb1e9c8526ebd1
https://pubmed.ncbi.nlm.nih.gov/29286466