Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Dominik Saul"'
Autor:
José Luis Villanueva-Cañas, Narcis Fernandez-Fuentes, Dominik Saul, Robyn Laura Kosinsky, Catherine Teyssier, Malgorzata Ewa Rogalska, Ferran Pegenaute Pérez, Baldomero Oliva, Cedric Notredame, Miguel Beato, Priyanka Sharma
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109584- (2024)
Summary: Peptidyl arginine deiminases (PADIs) catalyze protein citrullination, a post-translational conversion of arginine to citrulline. The most widely expressed member of this family, PADI2, regulates cellular processes that impact several disease
Externí odkaz:
https://doaj.org/article/dcca59766b1249ce963e9b46e07add27
Autor:
Madison L. Doolittle, Dominik Saul, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Kevin D. Pavelko, Joshua N. Farr, David G. Monroe, Sundeep Khosla
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Senescence drives organismal aging, yet the deep characterization of senescent cells in vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully validated antibodies to analyze senescent cells at single-cell r
Externí odkaz:
https://doaj.org/article/9fa996d1eacd483380e6493e7833f68e
Publikováno v:
JBMR Plus, Vol 7, Iss 10, Pp n/a-n/a (2023)
The regulation of bone mineral density (BMD) is highly influenced by genetics and age. Although genome‐wide association studies (GWAS) for BMD have uncovered many genes through their proximity to associated variants (variant nearest‐neighbor [VNN
Externí odkaz:
https://doaj.org/article/62ba4ba4720b42d3a231ab08683cbcf3
Autor:
Madison L. Doolittle, Brittany A. Eckhardt, Stephanie J. Vos, Sarah Grain, Jennifer L. Rowsey, Ming Ruan, Dominik Saul, Joshua N. Farr, Megan M. Weivoda, Sundeep Khosla, David G. Monroe
Publikováno v:
JBMR Plus, Vol 7, Iss 10, Pp n/a-n/a (2023)
ABSTRACT Estrogen regulates bone mass in women and men, but the underlying cellular mechanisms of estrogen action on bone remain unclear. Although both estrogen receptor (ER)α and ERβ are expressed in bone cells, ERα is the dominant receptor for s
Externí odkaz:
https://doaj.org/article/fce9a970aa3344afb432ff2b7082076c
Autor:
Japneet Kaur, Dominik Saul, Madison L. Doolittle, Joshua N. Farr, Sundeep Khosla, David G. Monroe
Publikováno v:
JBMR Plus, Vol 7, Iss 6, Pp n/a-n/a (2023)
ABSTRACT Aging is a major risk factor for most chronic diseases, including osteoporosis, and is characterized by an accumulation of senescent cells in various tissues. MicroRNAs (miRNAs) are critical regulators of bone aging and cellular senescence.
Externí odkaz:
https://doaj.org/article/26d0a15186a145048a5618b84caabc90
Publikováno v:
Cells, Vol 12, Iss 24, p 2787 (2023)
The high prevalence of sarcopenia in an aging population has an underestimated impact on quality of life by increasing the risk of falls and subsequent hospitalization. Unfortunately, the application of the major established key therapeutic—physica
Externí odkaz:
https://doaj.org/article/2d58720927c0492eb5510b146e85a646
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Autor:
Dominik Saul, Robyn Laura Kosinsky, Elizabeth J. Atkinson, Madison L. Doolittle, Xu Zhang, Nathan K. LeBrasseur, Robert J. Pignolo, Paul D. Robbins, Laura J. Niedernhofer, Yuji Ikeno, Diana Jurk, João F. Passos, LaTonya J. Hickson, Ailing Xue, David G. Monroe, Tamara Tchkonia, James L. Kirkland, Joshua N. Farr, Sundeep Khosla
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Identification of senescent cells in vivo remains a challenging task. Here the authors present and validate a senescence gene set called SenMayo enriched in human and murine aged tissues.
Externí odkaz:
https://doaj.org/article/e07e402c5be742719a9abae3ab241ab2
Autor:
Dominik Saul, Robyn Laura Kosinsky
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 5, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/17aa6d020172429d86c50cb14607439f
Autor:
Joshua N. Farr, Dominik Saul, Madison L. Doolittle, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Mitchell N. Froemming, Anthony B. Lagnado, Yi Zhu, Megan Weivoda, Yuji Ikeno, Robert J. Pignolo, Laura J. Niedernhofer, Paul D. Robbins, Diana Jurk, João F. Passos, Nathan K. LeBrasseur, Tamara Tchkonia, James L. Kirkland, David G. Monroe, Sundeep Khosla
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction remain unclear. Thus, we developed a mouse model (p16-LOX-ATTAC) th
Externí odkaz:
https://doaj.org/article/fc80a778d0594c49a7d28805675dc1fe
Publikováno v:
BMC Sports Science, Medicine and Rehabilitation, Vol 14, Iss 1, Pp 1-7 (2022)
Abstract Background Physiological characteristics of climbers have been extensively studied, while the personality of climbers remains poorly understood. Personality research in sports is an established field, predicting long-term success as well as
Externí odkaz:
https://doaj.org/article/ae420503999441dd9efffadca0a35dca