Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Dominik Paquet"'
Autor:
Caterina Carraro, Jessica V. Montgomery, Julien Klimmt, Dominik Paquet, Joachim L. Schultze, Marc D. Beyer
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Drug discovery is a generally inefficient and capital-intensive process. For neurodegenerative diseases (NDDs), the development of novel therapeutics is particularly urgent considering the long list of late-stage drug candidate failures. Although our
Externí odkaz:
https://doaj.org/article/cc824a0761f84b2da4bf8c5165eee655
Autor:
Ida Pesämaa, Stephan A. Müller, Sophie Robinson, Alana Darcher, Dominik Paquet, Henrik Zetterberg, Stefan F. Lichtenthaler, Christian Haass
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-18 (2023)
Abstract Background With the emergence of microglia-modulating therapies there is an urgent need for reliable biomarkers to evaluate microglial activation states. Methods Using mouse models and human induced pluripotent stem cell-derived microglia (h
Externí odkaz:
https://doaj.org/article/4f94573c7b924aa89443dd73131fdc40
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102266- (2023)
Summary: Human-induced-pluripotent-stem-cell (hiPSC)-derived neurons are valuable for investigating brain physiology and disease. Here, we present a protocol to differentiate hiPSCs into cortical neurons with high yield and purity. We describe neural
Externí odkaz:
https://doaj.org/article/b18b981ae40049798d20c869d6125a92
Autor:
Anna Scotto Rosato, Einar K Krogsaeter, Dawid Jaślan, Carla Abrahamian, Sandro Montefusco, Chiara Soldati, Barbara Spix, Maria Teresa Pizzo, Giuseppina Grieco, Julia Böck, Amanda Wyatt, Daniela Wünkhaus, Marcel Passon, Marc Stieglitz, Marco Keller, Guido Hermey, Sandra Markmann, Doris Gruber‐Schoffnegger, Susan Cotman, Ludger Johannes, Dennis Crusius, Ulrich Boehm, Christian Wahl‐Schott, Martin Biel, Franz Bracher, Elvira De Leonibus, Elena Polishchuk, Diego L Medina, Dominik Paquet, Christian Grimm
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 9, Pp 1-17 (2022)
Abstract Lysosomes are cell organelles that degrade macromolecules to recycle their components. If lysosomal degradative function is impaired, e.g., due to mutations in lysosomal enzymes or membrane proteins, lysosomal storage diseases (LSDs) can dev
Externí odkaz:
https://doaj.org/article/81fb1739060044f693962704d333fab5
Autor:
Chiara Soldati, Irene Lopez‐Fabuel, Luca G Wanderlingh, Marina Garcia‐Macia, Jlenia Monfregola, Alessandra Esposito, Gennaro Napolitano, Marta Guevara‐Ferrer, Anna Scotto Rosato, Einar K Krogsaeter, Dominik Paquet, Christian M Grimm, Sandro Montefusco, Thomas Braulke, Stephan Storch, Sara E Mole, Maria A De Matteis, Andrea Ballabio, Julio L Sampaio, Tristan McKay, Ludger Johannes, Juan P Bolaños, Diego L Medina
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 10, Pp 1-19 (2021)
Abstract Batten diseases (BDs) are a group of lysosomal storage disorders characterized by seizure, visual loss, and cognitive and motor deterioration. We discovered increased levels of globotriaosylceramide (Gb3) in cellular and murine models of CLN
Externí odkaz:
https://doaj.org/article/d6c8d9dd375c49b29d6deee58e6d431f
Autor:
Isabel Weisheit, Joseph A. Kroeger, Rainer Malik, Julien Klimmt, Dennis Crusius, Angelika Dannert, Martin Dichgans, Dominik Paquet
Publikováno v:
Cell Reports, Vol 31, Iss 8, Pp - (2020)
Summary: CRISPR genome editing is a promising tool for translational research but can cause undesired editing outcomes, both on target at the edited locus and off target at other genomic loci. Here, we investigate the occurrence of deleterious on-tar
Externí odkaz:
https://doaj.org/article/cfd2e95ca9644648bdad0df4aef8d0ba
Publikováno v:
Neurobiology of Disease, Vol 39, Iss 3, Pp 265-271 (2010)
Methylene blue is an FDA approved compound with a variety of pharmacologic activities. It inhibits aggregation of several amyloidogenic proteins known to be deposited in neurodegenerative diseases. Recently, it has been proposed that methylene blue s
Externí odkaz:
https://doaj.org/article/58c22d3fa5134bc0ac235044784489c3
Autor:
Mareike E Fett, Anna Pilsl, Dominik Paquet, Frauke van Bebber, Christian Haass, Jörg Tatzelt, Bettina Schmid, Konstanze F Winklhofer
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11783 (2010)
Mutations in the gene encoding the E3 ubiquitin ligase parkin (PARK2) are responsible for the majority of autosomal recessive parkinsonism. Similarly to other knockout mouse models of PD-associated genes, parkin knockout mice do not show a substantia
Externí odkaz:
https://doaj.org/article/88d7d03040ee4968a2ef81a834585572
Autor:
Francesco Bennardo, Ming Fai Chow, Jan Frederick Engels, David S. Goodsell, Georges M. Halpern, Oliver Kayser, Oliver Ullrich, Rita Bernhardt, Uwe Bornscheuer, George Cautherley, Ananda Chakrabarty, Emmanuelle Charpentier, King Chow, David P. Clark, Arnold L. Demain, Theodor Dingermann, Stefan Dübel, Roland Friedrich, Peter Fromherz, Dietmar Fuchs, Saburo Fukui, Karla Gänßler, Oreste Ghisalba, Horst Grunz, Georges Halpern, Albrecht Hempel, Choy-L. Hew, Franz Hillenkamp, Bertold Hock, Martin Holtzhauer, Jon Huntoon, Frank Kempken, Albrecht F. Kiderlen, Uwe Klenz, Louiza Law, Inca Lewen-Dörr, Hwa A. Lim, Jutta Ludwig-Müller, Stephan Martin, Alex Matter, Wolfgang Meyer, Marc van Montagu, Werner Müller-Esterl, Reinhard Niessner, Susanne Pauly, Jürgen Polle, Tom A. Rapoport, Matthias Reuss, Ralf Reski, Hermann Sahm, Frieder W. Scheller, Steffen Schmidt, Olaf Schulz, Georg Sprenger, Eric Stewart, Gary Strobel, Kurt Stüber, Atsuo Tanaka, Dieter Trau, Thomas Tuschl, Larry Wadsworth, Terence S.M. Wan, Zeng-yu Wang, Eckhard Wellmann, Michael Wink, Dieter Wolf, Leonhard Zastrow, Wolfgang Aehle, Werner Arber, Susan R. Barnum, Hildburg Beier, null Ian, John Billings, Ananda M. Chakrabarty, Cangel Pui Yee Chan, Charles Coutelle, Jared M. Diamond, Carl Djerassi, Akira Endo, Herrmann Feldmeier, Ernst Peter Fischer, Michael Gänzle, Erhard Geißler, Susan A. Greenfield, Alan E. Guttmacher, Christian Haass, Frank Hatzak, Sir Alec Jeffreys, Alexander Kekulé, Shukuo Kinoshita, Stephen Korsman, James W. Larrick, Frances S. Ligler, Alan MacDiarmid, Dominik Paquet, Uwe Perlitz, Ingo Potrykus, Wolfgang Preiser, Timothy H. Rainer, Jens Reich, Michael K. Richardson, Stefan Rokem, Michael Rossbach, Sujatha Sankula, Gottfried Schatz, Gerd Spelsberg, Gary A. Strobel, Jurgen Tautz, Christian Wandrey, Fuwen Wei, Katrine Whiteson, Ian Wilmut, Christoph Winterhalter, Eckhard Wolf, Boyd Woodruff, Daichang Yang, Holger Zinke
Publikováno v:
Biotechnology for Beginners ISBN: 9780323855693
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4022b41486ff5de334cdef2cfe4d9b18
https://doi.org/10.1016/b978-0-323-85569-3.09981-5
https://doi.org/10.1016/b978-0-323-85569-3.09981-5
Autor:
Anna Scotto Rosato, Einar K Krogsaeter, Dawid Jaślan, Carla Abrahamian, Sandro Montefusco, Chiara Soldati, Barbara Spix, Maria Teresa Pizzo, Giuseppina Grieco, Julia Böck, Amanda Wyatt, Daniela Wünkhaus, Marcel Passon, Marc Stieglitz, Marco Keller, Guido Hermey, Sandra Markmann, Doris Gruber‐Schoffnegger, Susan Cotman, Ludger Johannes, Dennis Crusius, Ulrich Boehm, Christian Wahl‐Schott, Martin Biel, Franz Bracher, Elvira De Leonibus, Elena Polishchuk, Diego L Medina, Dominik Paquet, Christian Grimm
Publikováno v:
EMBO Molecular Medicine. 14
Lysosomes are cell organelles that degrade macromolecules to recycle their components. If lysosomal degradative function is impaired, e.g., due to mutations in lysosomal enzymes or membrane proteins, lysosomal storage diseases (LSDs) can develop. LSD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0beaf2f72a21d6c00110b832eac5e3f
https://doi.org/10.15252/emmm.202115377
https://doi.org/10.15252/emmm.202115377