Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Dominik Niopek"'
Publikováno v:
Advanced Science, Vol 10, Iss 28, Pp n/a-n/a (2023)
Abstract Domain insertion engineering is a promising approach to recombine the functions of evolutionarily unrelated proteins. Insertion of light‐switchable receptor domains into a selected effector protein, for instance, can yield allosteric effec
Externí odkaz:
https://doaj.org/article/57d99c1e62b547e6b91c3cbcd6c45dbb
Autor:
Elena Senís, Lluc Mosteiro, Stefan Wilkening, Ellen Wiedtke, Ali Nowrouzi, Saira Afzal, Raffaele Fronza, Henrik Landerer, Maria Abad, Dominik Niopek, Manfred Schmidt, Manuel Serrano, Dirk Grimm
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
In vivo reprogramming of somatic cells is hampered by the need for vectors to express the OKSM factors in selected organs. Here the authors report new AAV-based vectors capable of in vivo reprogramming at low doses.
Externí odkaz:
https://doaj.org/article/097051282c3e433e8f3bfa8162e92d23
Autor:
Katharina Niopek, Bilgen Ekim Üstünel, Susanne Seitz, Minako Sakurai, Annika Zota, Frits Mattijssen, Xiaoyue Wang, Tjeerd Sijmonsma, Yvonne Feuchter, Anna M. Gail, Barbara Leuchs, Dominik Niopek, Oskar Staufer, Maik Brune, Carsten Sticht, Norbert Gretz, Karin Müller-Decker, Hans-Peter Hammes, Peter Nawroth, Thomas Fleming, Michael D. Conkright, Matthias Blüher, Anja Zeigerer, Stephan Herzig, Mauricio Berriel Diaz
Publikováno v:
Cell Reports, Vol 20, Iss 6, Pp 1422-1434 (2017)
Increased pro-inflammatory signaling is a hallmark of metabolic dysfunction in obesity and diabetes. Although both inflammatory and energy substrate handling processes represent critical layers of metabolic control, their molecular integration sites
Externí odkaz:
https://doaj.org/article/2202dbc7845d40ae91de1eae8c20361a
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Light-inducible control of protein subcellular localization holds great promise for synthetic biology applications and insights into basic cell biology. Here the authors develop a genetically-encoded light-inducible nuclear export system and apply it
Externí odkaz:
https://doaj.org/article/8e5dd11fb4324000ad98350457e5bc70
Autor:
Roland Eils, Stéphane Rosset, Andreas Scheck, Jan Mathony, Julius Upmeier zu Belzen, Wei Sun, Bruno E. Correia, Christina Stengl, Sandrine Georgeon, Dominik Niopek, Mareike D. Hoffmann, Sabine Aschenbrenner, Carolin Schmelas, Zander Harteveld, Yanli Wang, Dirk Grimm
Publikováno v:
Nature Chemical Biology. 16:725-730
Anti-CRISPR (Acr) proteins are powerful tools to control CRISPR-Cas technologies. However, the available Acr repertoire is limited to naturally occurring variants. Here, we applied structure-based design on AcrIIC1, a broad-spectrum CRISPR-Cas9 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::633addc7819fcadf4faf5cc3cab783af
https://doi.org/10.1038/s41589-020-0518-9
https://doi.org/10.1038/s41589-020-0518-9
Autor:
Bruno E. Correia, Daniel Heid, Jan Mathony, Tobias Stadelmann, Stéphane Rosset, Michael Jendrusch, Dominik Niopek
Deep mutational scanning is a powerful method to explore the mutational fitness landscape of proteins. Its adaptation to anti-CRISPR proteins, which are natural CRISPR-Cas inhibitors and key players in the co-evolution of microbes and phages, would f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9873dcc1182f05c0cb78244d47ecfa99
https://doi.org/10.1101/2021.08.21.457204
https://doi.org/10.1101/2021.08.21.457204
Autor:
Chiara Di Ponzio, Roland Eils, Lukas Adam, Jan Mathony, Dominik Niopek, Megan L. Stanifer, Steeve Boulant, Stefan M Kallenberger, Fabian Springer
The worldwide spread of severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) caused an urgent need for an in-depth understanding of interactions between the virus and its host. Here, we dissected the dynamics of virus replication and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6d0bb0a3fc0cb1d9f6de7cf189dad79
https://doi.org/10.1101/2021.07.04.450986
https://doi.org/10.1101/2021.07.04.450986
Autor:
Daniel Heid, Dominik Niopek, Max C. Waldhauer, Irina Lehmann, Moritz Jakob Przybilla, Pauline L. Pfuderer, Roland Eils, Thore Bürgel, Catharina Gandor, Marita Klein, Mareike D. Hoffmann, Carolin Schmelas, Felix Bubeck, Julius Upmeier zu Belzen, Lukas Platz, Jan Mathony, Lukas Adam, Stefan Holderbach, Max Schwendemann, Michael Jendrusch
Publikováno v:
Nature Machine Intelligence. 1:225-235
Proteins are nature’s most versatile molecular machines. Deep neural networks trained on large protein datasets have recently been used to tackle the unmet complexity of protein sequence–function relationships. The implicit knowledge contained in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10e606d599d7c8b4e6ebd1de2fc5b7df
https://doi.org/10.1038/s42256-019-0049-9
https://doi.org/10.1038/s42256-019-0049-9
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2173
Since the breakthrough discoveries that CRISPR-Cas9 nucleases can be easily programmed and employed to induce targeted double-strand breaks in mammalian cells, the gene editing field has grown exponentially. Today, CRISPR technologies based on engine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b3731d023d04a772eab6aa71b13c144
https://pubmed.ncbi.nlm.nih.gov/32651924
https://pubmed.ncbi.nlm.nih.gov/32651924
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2173
CRISPR labeling is a powerful technique to study the chromatin architecture in live cells. In CRISPR labeling, a catalytically dead CRISPR-Cas9 mutant is employed as programmable DNA-binding domain to recruit fluorescent proteins to selected genomic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b6526b081293678d257b21d85f107d59
https://pubmed.ncbi.nlm.nih.gov/32651915
https://pubmed.ncbi.nlm.nih.gov/32651915