Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Dominik M Loy"'
1
Combination Chemotherapy of L1210 Tumors in Mice with Pretubulysin and Methotrexate Lipo-Oligomer Nanoparticles
Autor: Uli Kazmaier, Ines Truebenbach, Dominik M. Loy, Miriam Höhn, Sarah Kern, Ernst Wagner, Jan Gorges
Publikováno v: Molecular Pharmaceutics. 16:2405-2417
In the current study, nanoparticles containing the antimetabolite drug methotrexate (MTX) and the novel tubulin-binding drug pretubulysin (PT) were developed for combination chemotherapy. Polyelectrolyte complexes were formed based on ∼20 nm cation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9548b9f5df1b01b3b3db645341b97963
https://doi.org/10.1021/acs.molpharmaceut.9b00038
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2
Controlling Nanoparticle Formulation: A Low-Budget Prototype for the Automation of a Microfluidic Platform
Autor: Rafał Krzysztoń, Ernst Wagner, Ulrich Lächelt, Joachim O. Rädler, Dominik M. Loy
Publikováno v: Processes, Vol 9, Iss 129, p 129 (2021)
Processes
Volume 9
Issue 1
Active pharmaceutical ingredients (API) with suboptimal pharmacokinetic properties may require formulation into nanoparticles. In addition to the quality of the excipients, production parameters are crucial for producing nanoparticles which reliably
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5865f49540b4513602a4c63c851a5ed7
https://www.mdpi.com/2227-9717/9/1/129
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3
A microfluidic approach for sequential assembly of siRNA polyplexes with defined structure – activity relationship
Autor: Dominik M Loy, Philipp M Klein, Rafał Krzysztoń, Ulrich Lächelt, Joachim O Rädler, Ernst Wagner
Therapeutic nucleic acids provide versatile treatment options for hereditary or acquired diseases. Ionic complexes with basic polymers are frequently used to facilitate nucleic acid’s transport to intracellular target sites. Usually, these polyplex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31272e675abfa35b42d232bd279093cc
https://doi.org/10.7287/peerj.preprints.27669v1
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4
A microfluidic approach for sequential assembly of siRNA polyplexes with a defined structure-activity relationship
Autor: Rafał Krzysztoń, Philipp M. Klein, Ulrich Lächelt, Ernst Wagner, Joachim O. Rädler, Dominik M. Loy
Publikováno v: PeerJ Materials Science. 1:e1
Therapeutic nucleic acids provide versatile treatment options for hereditary or acquired diseases. Ionic complexes with basic polymers are frequently used to facilitate nucleic acid’s transport to intracellular target sites. Usually, these polyplex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b829037a8927b3d5f225d0a74ac75ea
https://doi.org/10.7717/peerj-matsci.1
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5
Supramolecular Assembly of Aminoethylene‐Lipopeptide PMO Conjugates into RNA Splice‐Switching Nanomicelles
Autor: Samir El Andaloussi, Jasmin Kuhn, Ulrich Lächelt, Philipp M. Klein, Miriam Höhn, Don C. Lamb, Yoshitsugu Aoki, Joel Z. Nordin, Ernst Wagner, Nader Al Danaf, Dominik M. Loy, Taavi Lehto, Sören Reinhard
Publikováno v: Advanced Functional Materials. 29:1906432
Phosphorodiamidate morpholino oligomers (PMOs) are oligonucleotide analogs that can be used for therapeutic modulation of pre‐mRNA splicing. Similar to other classes of nucleic acid‐based therapeutics, PMOs require delivery systems for efficient
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a476553803684714833db66c3ca1f2a
https://doi.org/10.1002/adfm.201906432
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