Výsledky vyhledávání - "Dominik Kugelstadt"

BBA70 of Borrelia burgdorferi Is a Novel Plasminogen-binding Protein

Autor: Brian Stevenson, Diana Barthel, Dominik Kugelstadt, Denys Pogoryelov, Claudia Hammerschmidt, Arno Koenigs, Peter F. Zipfel, Peter Kraiczy, Reinhard Wallich, Christine Skerka, Brandon L. Jutras

Publikováno v: Journal of Biological Chemistry. 288:25229-25243

The Lyme disease spirochete Borrelia burgdorferi lacks endogenous, surface-exposed proteases. In order to efficiently disseminate throughout the host and penetrate tissue barriers, borreliae rely on recruitment of host proteases, such as plasmin(ogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2896565a2fdb72248d5bfd679870e208
https://doi.org/10.1074/jbc.m112.413872

Zobrazit plný text záznamu

Calcium‐Dependent Protein Kinases as Drug Targets in Apicomplexan Parasites

Autor: Barbara Kappes, Bianca Derrer, Dominik Kugelstadt

Publikováno v: Apicomplexan Parasites: Molecular Approaches toward Targeted Drug Development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7c6505e2e3a0201463cc762be73fdf7
https://doi.org/10.1002/9783527633883.ch17

Zobrazit plný text záznamu

Minimally permutated peptide analogs as internal standards for relative and absolute quantification of peptides and proteins

Autor: Barbara Kappes, Joerg Seidler, Dominic Winter, Wolf D. Lehmann, Bianca Derrer, Dominik Kugelstadt

Publikováno v: PROTEOMICS. 10:1510-1514

A novel type of isobaric internal peptide standard for quantitative proteomics is described. The standard is a synthetic peptide derived from the target peptide by positional permutation of two amino acids. This type of internal standard is denominat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2fb19be15212a181d617f94206be616
https://doi.org/10.1002/pmic.200900695

Zobrazit plný text záznamu

Protein phosphorylation influences proteolytic cleavage and kinase substrate properties exemplified by analysis of in vitro phosphorylated Plasmodium falciparum glideosome-associated protein 45 by nano-ultra performance liquid chromatography–tandem mass spectrometry

Autor: Wolf D. Lehmann, Joerg Seidler, Dominic Winter, Dominik Kugelstadt, Barbara Kappes

Publikováno v: Analytical Biochemistry. 393:41-47

Plasmodium falciparum glideosome-associated protein 45 (PfGAP45) was in vitro phosphorylated by P. falciparum calcium-dependent protein kinase (PfCDPK1) and digested using the four proteases trypsin, chymotrypsin, AspN, and elastase. Subsequently, ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5772b90927693af52167d4cac8f1be
https://doi.org/10.1016/j.ab.2009.06.022

Zobrazit plný text záznamu

Raf kinase inhibitor protein affects activity of Plasmodium falciparum calcium-dependent protein kinase 1

Autor: Kirsten Plückhahn, Barbara Kappes, Dominik Kugelstadt, Wolf D. Lehmann, Dominic Winter

Publikováno v: Molecular and Biochemical Parasitology. 151:111-117

Proteins, such as the raf kinase inhibitory protein (RKIP), serve as modulators of signalling pathways by either promoting or inhibiting the formation of productive signalling complexes through protein–protein interactions. In the present study, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b633443bf51595d657ee2126255cb50b
https://doi.org/10.1016/j.molbiopara.2006.10.012

Zobrazit plný text záznamu

Neuroglobin, cytoglobin, and a novel, eye-specific globin from chicken

Autor: Dominik Kugelstadt, Thorsten Burmester, Thomas Hankeln, Mark Haberkamp

Publikováno v: Biochemical and Biophysical Research Communications. 325:719-725

Neuroglobin and cytoglobin are two recently discovered respiratory proteins of vertebrates. Here we report the first identification and expression analyses of these proteins in bird species. Neuroglobin from the domestic chicken Gallus gallus differs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91bd956177a801766a6014bf5276eaa
https://doi.org/10.1016/j.bbrc.2004.10.080

Zobrazit plný text záznamu

Long-term intrathecal infusion of outer surface protein C from Borrelia burgdorferi causes axonal damage

Autor: Dominik Kugelstadt, Torsten Heinz, Stephanie Bunkowski, Annette Spreer, Sandra Ribes, Helmut Eiffert, Olaf Jahn, Simone C. Tauber, Sandra Ebert, Roland Nau, Volker Fingerle

Publikováno v: Journal of neuropathology and experimental neurology. 70(9)

Lyme neuroborreliosis (LNB) is the most frequent tick-borne infectious disease of the central nervous system. In acute LNB and the rare chronic state of infection, patients can experience cognitive deficits such as attention and memory disturbances.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5900830c71af4890c58485fbf9f194f
https://pubmed.ncbi.nlm.nih.gov/21865883

Zobrazit plný text záznamu

Identification and characterization of novel small molecules as potent inhibitors of the plasmodial calcium-dependent protein kinase 1

Autor: Dominik Kugelstadt, Matthias Schwarz, Mathias M. Domostoj, Guillaume Lemercier, Amaury Ernesto Fernandez-Montalvan, Jeffrey P. Shaw, Alexander Scheer, Didier Leroy, Joerg Bomke, Barbara Kappes

Publikováno v: Biochemistry. 48(27)

Malaria remains a major killer in many parts of the world. Recently, there has been an increase in the role of public-private partnerships inciting academic and industrial scientists to merge their expertise in drug-target validation and in the early

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610e98ea835cd4584e996b93db6f9e27
https://pubmed.ncbi.nlm.nih.gov/19507895

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání