Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Dominik Kirchhofer"'
Autor:
Lisa Gabler, Carola Nadine Jaunecker, Sonja Katz, Sushilla van Schoonhoven, Bernhard Englinger, Christine Pirker, Thomas Mohr, Petra Vician, Mirjana Stojanovic, Valentin Woitzuck, Anna Laemmerer, Dominik Kirchhofer, Lisa Mayr, Mery LaFranca, Friedrich Erhart, Sarah Grissenberger, Andrea Wenninger-Weinzierl, Caterina Sturtzel, Barbara Kiesel, Alexandra Lang, Brigitte Marian, Bettina Grasl-Kraupp, Martin Distel, Julia Schüler, Johannes Gojo, Michael Grusch, Sabine Spiegl-Kreinecker, Daniel J. Donoghue, Daniela Lötsch, Walter Berger
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-16 (2022)
Abstract Glioblastoma (GBM) is characterized by a particularly invasive phenotype, supported by oncogenic signals from the fibroblast growth factor (FGF)/ FGF receptor (FGFR) network. However, a possible role of FGFR4 remained elusive so far. Several
Externí odkaz:
https://doaj.org/article/a09b2bdbe34d4252a9676846e4f372c1
Autor:
Lisa Gabler, Daniela Lötsch, Dominik Kirchhofer, Sushilla van Schoonhoven, Hannah M. Schmidt, Lisa Mayr, Christine Pirker, Katharina Neumayer, Carina Dinhof, Lucia Kastler, Amedeo A. Azizi, Christian Dorfer, Thomas Czech, Christine Haberler, Andreas Peyrl, Rajiv Kumar, Irene Slavc, Sabine Spiegl-Kreinecker, Johannes Gojo, Walter Berger
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-16 (2019)
Abstract The BRAF gene and the TERT promoter are among the most frequently altered genomic loci in low-grade (LGG) and high-grade-glioma (HGG), respectively. The coexistence of BRAF and TERT promoter aberrations characterizes a subset of aggressive g
Externí odkaz:
https://doaj.org/article/0d0f5c425b5246679d273f73084e3798
Autor:
Dina Baier, Beatrix Schoenhacker-Alte, Mate Rusz, Christine Pirker, Thomas Mohr, Theresa Mendrina, Dominik Kirchhofer, Samuel M. Meier-Menches, Katharina Hohenwallner, Martin Schaier, Evelyn Rampler, Gunda Koellensperger, Petra Heffeter, Bernhard Keppler, Walter Berger
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 238 (2022)
Cellular energy metabolism is reprogrammed in cancer to fuel proliferation. In oncological therapy, treatment resistance remains an obstacle and is frequently linked to metabolic perturbations. Identifying metabolic changes as vulnerabilities opens u
Externí odkaz:
https://doaj.org/article/7c0e455d4c484ce7be28ed3666638e66
Autor:
Anna Schrempf, Sara Bernardo, Emili A. Arasa Verge, Miguel A. Ramirez Otero, Jordan Wilson, Dominik Kirchhofer, Gerald Timelthaler, Anna M. Ambros, Atilla Kaya, Marcus Wieder, Gerhard F. Ecker, Georg E. Winter, Vincenzo Costanzo, Joanna I. Loizou
Publikováno v:
Cell reports. 41(9)
Polymerase theta (POLθ) is an error-prone DNA polymerase whose loss is synthetically lethal in cancer cells bearing breast cancer susceptibility proteins 1 and 2 (BRCA1/2) mutations. To investigate the basis of this genetic interaction, we utilized
Autor:
Dina Baier, Beatrix Schoenhacker-Alte, Mate Rusz, Christine Pirker, Thomas Mohr, Theresa Mendrina, Dominik Kirchhofer, Samuel M. Meier-Menches, Katharina Hohenwallner, Martin Schaier, Evelyn Rampler, Gunda Koellensperger, Petra Heffeter, Bernhard Keppler, Walter Berger
Publikováno v:
Pharmaceutics; Volume 14; Issue 2; Pages: 238
Cellular energy metabolism is reprogrammed in cancer to fuel proliferation. In oncological therapy, treatment resistance remains an obstacle and is frequently linked to metabolic perturbations. Identifying metabolic changes as vulnerabilities opens u
Autor:
Carola Jaunecker, Daniela Lötsch-Gojo, Walter Berger, Lisa Mayr, Karl Roessler, Sabine Spiegl-Kreinecker, Katharina Bruckner, Dominik Kirchhofer, Sibylle Madlener, Johannes Gojo, Kerstin Fürnweger, Lisa Gabler
Publikováno v:
Neuro Oncol
Activating point mutations within the TERT promoter (C228T or C250T) account for the most frequent alteration in aggressive brain tumors. Presence of these alterations results in the generation of binding sites for E-twenty-six (ETS) transcription fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20b3803572c1c9937f2e7656c39c0ec
https://europepmc.org/articles/PMC8598620/
https://europepmc.org/articles/PMC8598620/
Autor:
Martin Piontek, Dominik Kirchhofer, Lisa Gabler, Daniela Lötsch-Gojo, Christine Pirker, Felix Schmitt-Hoffner, Carola N Jaunecker, Marcel Kool, Walter Berger, Johannes Gojo
Publikováno v:
Neuro-Oncology. 24:i51-i52
BCL-6 transcriptional corepressor (BCOR) is an epigenetic regulator that silences gene expression mainly via the polycomb repressive complex 1.1 (PRC1.1). BCOR genomic alterations are found in a variety of different tumors and recently central nervou
Autor:
Christian Dorfer, Andreas Peyrl, Karl Roessler, Carola Jaunecker, Christine Pirker, Walter Berger, Sabine Spiegl-Kreinecker, Lisa Mayr, Johannes Gojo, Christine Haberler, Anna Laemmerer, Irene Slavc, Lucia Kastler, Thomas Czech, Dominik Kirchhofer, Daniela Lötsch-Gojo, Amedeo A. Azizi, Lisa Gabler
Publikováno v:
Neuro-Oncology. 23:vi33-vi34
BACKGROUND High-grade gliomas are among the most aggressive brain tumors across all age groups. BRAF is within the most frequently altered genes in pediatric glioma, sometimes connected with telomerase reverse transcriptase (TERT) promoter mutations,
Autor:
Dominik Kirchhofer, Daniela Lötsch-Gojo, Lisa Gabler, Carola N Jaunecker, Martin Piontek, Lisa Mayr, Bernhard Englinger, Christine Pirker, Thomas Mohr, Anna Lämmerer, Felix Schmitt-Hoffner, Bernd Boidol, Stefan Kubiceck, Andreas Peyrl, Amadeo A Azizi, Christian Dorfer, Christine Haberler, Marcel Kool, Walter Berger, Johannes Gojo
Publikováno v:
Neuro-Oncology. 24:i52-i52
Central nervous system (CNS) tumors with BCOR internal tandem duplications (CNS-BCOR ITD) are aggressive malignancies recently included in the 2021 WHO Classification of CNS tumors. This entity is characterized by ITDs within the PUFD domain of BCOR,
Autor:
Katharina Bruckner, Lisa Mayr, Romana Sickha, Aniello Frederico, Sibylle Madlener, Lisa Gabler, Dominik Kirchhofer, Karl Roessler, Natalie Jäger, Walter Berger, Marcel Kool, Stefan M Pfister, Julia Schueler, Johannes Gojo, Daniela Lötsch-Gojo
Publikováno v:
Neuro-Oncology. 24:i171-i171
Medulloblastoma (MB) is the most common embryonal brain tumor in children, characterized by a high level of heterogeneity within this entity. Four major molecular groups have been defined - WNT, Sonic hedgehog (SHH), Group 3 (G3), and Group 4 (G4) -