Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dominik J. Otto"'
Autor:
Derek H. Janssens, Melodie Duran, Dominik J. Otto, Weifang Wu, Yiling Xu, Danielle Kirkey, Charles G. Mullighan, Joanna S. Yi, Soheil Meshinchi, Jay F. Sarthy, Kami Ahmad, Steven Henikoff
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Chromosomal translocations involving the mixed-lineage leukemia (MLL) locus generate potent oncogenic fusion proteins (oncoproteins) that disrupt regulation of developmental gene expression. By profiling the oncoprotein-target sites of 36 br
Externí odkaz:
https://doaj.org/article/ea636cfdd021408692f0ace826848682
Autor:
Michael Rade, Markus Kreuz, Angelika Borkowetz, Ulrich Sommer, Conny Blumert, Susanne Füssel, Catharina Bertram, Dennis Löffler, Dominik J. Otto, Livia A. Wöller, Carolin Schimmelpfennig, Ulrike Köhl, Ann-Cathrin Gottschling, Pia Hönscheid, Gustavo B. Baretton, Manfred Wirth, Christian Thomas, Friedemann Horn, Kristin Reiche
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-20 (2024)
Abstract Background Clinical manifestation of prostate cancer (PCa) is highly variable. Aggressive tumors require radical treatment while clinically non-significant ones may be suitable for active surveillance. We previously developed the prognostic
Externí odkaz:
https://doaj.org/article/c464d6da04a84fa9b2ebac3773083177
Autor:
Carolin Schimmelpfennig, Michael Rade, Susanne Füssel, Dennis Löffler, Conny Blumert, Catharina Bertram, Angelika Borkowetz, Dominik J. Otto, Sven-Holger Puppel, Pia Hönscheid, Ulrich Sommer, Gustavo B. Baretton, Ulrike Köhl, Manfred Wirth, Christian Thomas, Friedemann Horn, Markus Kreuz, Kristin Reiche
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-20 (2023)
Abstract Background Prostate cancer (PCa) is one of the most prevalent cancers worldwide. The clinical manifestations and molecular characteristics of PCa are highly variable. Aggressive types require radical treatment, whereas indolent ones may be s
Externí odkaz:
https://doaj.org/article/33f9e042a8f748879f7f4908f10f205d
Autor:
Derek H. Janssens, Dominik J. Otto, Michael P. Meers, Manu Setty, Kami Ahmad, Steven Henikoff
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Cleavage Under Targets and Tagmentation (CUT&Tag) is an antibody-directed transposase tethering strategy for in situ chromatin profiling in small samples and single cells. We describe a modified CUT&Tag protocol using a mixture of an antibod
Externí odkaz:
https://doaj.org/article/2363434c279348e18326a59aafb527f7
Autor:
Derek H. Janssens, Dominik J. Otto, Michael P. Meers, Manu Setty, Kami Ahmad, Steven Henikoff
SummaryCleavage Under Targets & Tagmentation (CUT&Tag) is an antibody-directed transposase tethering strategy for in situ chromatin profiling in small samples and single cells. We describe a modified CUT&Tag protocol using a mixture of an antibody to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dceb2640b4cc34ab92dc809eee77c2e
https://doi.org/10.1101/2021.12.19.473377
https://doi.org/10.1101/2021.12.19.473377
Autor:
Derek H. Janssens, Dominik J. Otto, Michael P. Meers, Manu Setty, Kami Ahmad, Steven Henikoff
Publikováno v:
Genome biology. 23(1)
Cleavage Under Targets and Tagmentation (CUT&Tag) is an antibody-directed transposase tethering strategy for in situ chromatin profiling in small samples and single cells. We describe a modified CUT&Tag protocol using a mixture of an antibody to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf45e5d97492f6cb437df7870591593e
https://pubmed.ncbi.nlm.nih.gov/35300717
https://pubmed.ncbi.nlm.nih.gov/35300717
Autor:
Markus Kreuz, Ulf-Dietrich Braumann, Markus Bauer, Georg Popp, Sebastian Zürner, Dominik J. Otto
Publikováno v:
Medical Imaging 2021: Digital Pathology.
In today’s clinical routine, malignant changes in the prostate’s structure are evaluated based on the Gleason grading system. An inevitable variability of the histopathological grading and thus a lack of reproducibility have led to a wide variety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d98ea5b710da6b72ab21b667c8472c6
https://doi.org/10.1117/12.2581043
https://doi.org/10.1117/12.2581043
Autor:
Catharina Bertram, Giorgio Gandaglia, Kristin Reiche, Sven Holger Puppel, Alberto Briganti, Kati Erdmann, Massimo Freschi, Susanne Fuessel, Sabina Christ, Dominik J. Otto, Tilo Buschmann, Michael Froehner, Michael H. Muders, Fabio Benigni, Maik Friedrich, Conny Blumert, Gustavo B. Baretton, Jörg Hackermüller, Friedemann Horn, Marieta Toma, Michael Rade, Markus Loeffler, Michael Specht, Stephan Schreiber, Dennis Loeffler, Markus Kreuz, Manfred P. Wirth, Sophie Bartsch
Background Prostate cancer (PCa) is the most prevalent solid cancer among men in Western Countries. The clinical behavior of localized PCa is highly variable. Some cancers are aggressive leading to death, while others can even be monitored safely. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88437996f93d01755328b909b7dc0a3
https://publica.fraunhofer.de/handle/publica/263245
https://publica.fraunhofer.de/handle/publica/263245