Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Dominik Haddad"'
Autor:
Jeremy W. Linsley, Kevan Shah, Nicholas Castello, Michelle Chan, Dominik Haddad, Zak Doric, Shijie Wang, Wiktoria Leks, Jay Mancini, Viral Oza, Ashkan Javaherian, Ken Nakamura, David Kokel, Steven Finkbeiner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Cell death is a critical process in health and disease, yet available markers record later stages of cell death once a cell has already begun to decompose. Here the authors show the use of a genetically encoded calcium indicator that demarcates an ir
Externí odkaz:
https://doaj.org/article/2c47160676034ab2bc322fd5c88405c2
Autor:
Sven Vilain, Giovanni Esposito, Dominik Haddad, Onno Schaap, Mariya P Dobreva, Melissa Vos, Stefanie Van Meensel, Vanessa A Morais, Bart De Strooper, Patrik Verstreken
Publikováno v:
PLoS Genetics, Vol 8, Iss 1, p e1002456 (2012)
Pink1 is a mitochondrial kinase involved in Parkinson's disease, and loss of Pink1 function affects mitochondrial morphology via a pathway involving Parkin and components of the mitochondrial remodeling machinery. Pink1 loss also affects the enzymati
Externí odkaz:
https://doaj.org/article/fab4c4340126431da8700027a5a93c2d
Autor:
Sangwook Jung, Pavel I. Zimin, Christian B. Woods, Ernst-Bernhard Kayser, Dominik Haddad, Colleen R. Reczek, Ken Nakamura, Jan-Marino Ramirez, Margaret M. Sedensky, Philip G. Morgan
Publikováno v:
Current biology : CB. 32(14)
The mechanisms of volatile anesthetic action remain among the most perplexing mysteries of medicine. Across phylogeny, volatile anesthetics selectively inhibit mitochondrial complex I, and they also depress presynaptic excitatory signaling. To explor
Autor:
Lauren Y. Shields, Zak Doric, Hwajin Kim, Meredith E. K. Calvert, Ken Nakamura, Dominik Haddad, Huihui Li, Kevin Nguyen, T. Michael Gill, Keith A. Vossel
Alterations in mitochondrial fission may contribute to the pathophysiology of several neurodegenerative diseases, including Alzheimer’s disease (AD). However, we understand very little about the normal functions of fission, or how fission disruptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca093d7ebf11e407d87f2bf33240f3b2
Autor:
Ken Nakamura, Kevin Nguyen, Dominik Haddad, Hwajin Kim, Keith A. Vossel, Meredith E. K. Calvert, Lauren Y. Shields, Zak Doric, T. Michael Gill, Joseph H. Garcia, Huihui Li
Publikováno v:
The Journal of Biological Chemistry
Alterations in mitochondrial fission may contribute to the pathophysiology of several neurodegenerative diseases, including Alzheimer’s disease (AD). However, we understand very little about the normal functions of fission or how fission disruption
Autor:
Ken Nakamura, Dominik Haddad
Publikováno v:
FEBS letters, vol 589, iss 24 Pt A
Mitochondria are undoubtedly changed in Parkinson's disease (PD), and mitochondrial functions are disrupted in genetic and pharmacologic models of PD. However, many of these changes might not truly drive neurodegeneration. PD is defined by the partic
Autor:
Patrik Verstreken, Bart De Strooper, Samer Matta, Rafaella M.P. Nascimento, Vanessa A. Morais, Hilde Van Esch, Angela Maria Vianna-Morgante, Dominik Haddad, Giovanni Esposito, Maarten Leyssen, Katleen Craessaerts, Vera M. Kalscheuer, Sven Vilain, Melissa Vos
Publikováno v:
Molecular Cell; Vol 50
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Molecular Cell
Europe PubMed Central
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Molecular Cell
Europe PubMed Central
The prevalence of intellectual disability is around 3%; however, the etiology of the disease remains unclear in most cases. We identified a series of patients with X-linked intellectual disability presenting mutations in the Rad6a (Ube2a) gene, which
Autor:
Patrik Verstreken, Dominik Haddad
Publikováno v:
Lysosomes: Biology, Diseases, and Therapeutics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54ebc6c46d610b3860fbf7843a72c58d
https://doi.org/10.1002/9781118978320.ch4
https://doi.org/10.1002/9781118978320.ch4
Autor:
Ken Nakamura, Dominik Haddad
Publikováno v:
Cell Chemical Biology. 24:429-430
Stimulating autophagy is a promising therapeutic strategy for slowing the progression of neurodegenerative disease. Neurons are insensitive to current approaches based on mTOR inhibition for activating autophagy, and instead may rely on the Parkinson
Publikováno v:
ISRN Microbiology
Molecular characterization of Staphylococcus aureus is of both clinical and infection control importance. Virulence determinants using PCR and multiple drug resistance profiles were studied in 130 S. aureus isolates. PCR-RFLP analysis of the 16S–23