Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Dominik Boos"'
Autor:
Matthew Day, Bilal Tetik, Milena Parlak, Yasser Almeida-Hernández, Markus Räschle, Farnusch Kaschani, Heike Siegert, Anika Marko, Elsa Sanchez-Garcia, Markus Kaiser, Isabel A. Barker, Laurence H. Pearl, Antony W. Oliver, Dominik Boos
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Activation of the replicative Mcm2-7 helicase by loading GINS and Cdc45 is crucial for replication origin firing, and as such for faithful genetic inheritance. Our biochemical and structural studies demonstrate that the helicase activator GI
Externí odkaz:
https://doaj.org/article/91e316aec1f548cab215f4d414dc36db
Autor:
Pedro Ferreira, Verena Höfer, Nora Kronshage, Anika Marko, Karl-Uwe Reusswig, Bilal Tetik, Christoph Dießel, Kerstin Köhler, Nikolai Tschernoster, Janine Altmüller, Nina Schulze, Boris Pfander, Dominik Boos
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Faithful genome duplication requires regulation of origin firing to determine loci, timing and efficiency of replisome generation. Established kinase targets for eukaryotic origin firing regulation are the Mcm2-7 helicase, Sld3/Treslin/TICRR
Externí odkaz:
https://doaj.org/article/92ce71894c5a4deda55584773b6d15ac
Publikováno v:
Biology, Vol 11, Iss 6, p 827 (2022)
The initiation step of replication at replication origins determines when and where in the genome replication machines, replisomes, are generated. Tight control of replication initiation helps facilitate the two main tasks of genome replication, to d
Externí odkaz:
https://doaj.org/article/4fcbec9084d640e9b96cc758e7a6cdb4
Autor:
Kerstin Köhler, Luis Sanchez-Pulido, Verena Höfer, Anika Marko, Chris P Ponting, Ambrosius P Snijders, Regina Feederle, Aloys Schepers, Dominik Boos
Publikováno v:
PLoS Biology, Vol 17, Iss 1, p e2006767 (2019)
Accurate genome duplication underlies genetic homeostasis. Metazoan Mdm2 binding protein (MTBP) forms a main regulatory platform for origin firing together with Treslin/TICRR and TopBP1 (Topoisomerase II binding protein 1 (TopBP1)-interacting replica
Externí odkaz:
https://doaj.org/article/cbe3c8776c044af9ab1fff82c10c7f32
Autor:
Matthew Day, Mathieu Rappas, Katie Ptasinska, Dominik Boos, Antony W Oliver, Laurence H Pearl
Publikováno v:
eLife, Vol 7 (2018)
TOPBP1 and its fission yeast homologue Rad4, are critical players in a range of DNA replication, repair and damage signalling processes. They are composed of multiple BRCT domains, some of which bind phosphorylated motifs in other proteins. They thus
Externí odkaz:
https://doaj.org/article/63e82e1173f6422187a3405f665b6d76
Publikováno v:
eLife, Vol 6 (2017)
DNA double strand breaks (DSBs) can be repaired by either recombination-based or direct ligation-based mechanisms. Pathway choice is made at the level of DNA end resection, a nucleolytic processing step, which primes DSBs for repair by recombination.
Externí odkaz:
https://doaj.org/article/ef8b448e2e54473fafcf2affafe50b11
Autor:
Dominik Boos
Publikováno v:
Zeitschrift Kunststofftechnik. 1:118-164
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ba1166d6a371da8a0e3f9828ac26403
https://doi.org/10.3139/o999.01032023
https://doi.org/10.3139/o999.01032023
Autor:
Matthew Day, Bilal Tetik, Milena Parlak, Yasser Almeida-Hernández, Markus Räschle, Farnusch Kaschani, Heike Siegert, Anika Marko, Elsa Sanchez-Garcia, Markus Kaiser, Isabel A. Barker, Laurence H. Pearl, Antony W. Oliver, Dominik Boos
How the replicative Mcm2-7 helicase is activated during replication origin firing remains largely unknown. Our biochemical and structural studies reported here, demonstrate that the helicase activator GINS interacts with TopBP1 through two separate b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c87ef96a2c3ea57289ac5d3d917811
https://doi.org/10.1101/2023.03.31.535063
https://doi.org/10.1101/2023.03.31.535063
Mutations do not occur uniformly across genomes but instead show biased associations with various genomic features, most notably late replication timing. However, it remains contested which mutation types in human cells relate to DNA replication dyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::949138457a508ac8bd9959054ad88f2f
https://doi.org/10.1101/2022.09.28.509938
https://doi.org/10.1101/2022.09.28.509938
Publikováno v:
Proceedings of the Munich Symposium on Lightweight Design 2021 ISBN: 9783662652152
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5cc901f1b63c60bcfd237c333aa2207
https://doi.org/10.1007/978-3-662-65216-9_4
https://doi.org/10.1007/978-3-662-65216-9_4