Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Dominik Awad"'
Autor:
Mack B. Reynolds, Benjamin Klein, Michael J. McFadden, Norah K. Judge, Hannah E. Navarrete, Britton C Michmerhuizen, Dominik Awad, Tracey L. Schultz, Paul W. Harms, Li Zhang, Teresa R. O’Meara, Jonathan Z. Sexton, Costas A. Lyssiotis, J. Michelle Kahlenberg, Mary X. O’Riordan
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114607- (2024)
Summary: Macrophage metabolic plasticity is central to inflammatory programming, yet mechanisms of coordinating metabolic and inflammatory programs during infection are poorly defined. Here, we show that type I interferon (IFN) temporally guides meta
Externí odkaz:
https://doaj.org/article/b80ebd8315f645efa79adec43f6f9598
Autor:
Carrow Wells, Yi Liang, Thomas L. Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O’Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, Opher Gileadi, Carina Gileadi, Rafael M. Couñago, Brittany Stork, Christopher G. Langendorf, Kevin Nay, Jonathan S. Oakhill, Debarati Mukherjee, Luigi Racioppi, Anthony R. Means, Brian York, Donald P. McDonnell, John W. Scott, Daniel E. Frigo, David H. Drewry
Publikováno v:
Cells, Vol 12, Iss 2, p 287 (2023)
The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a se
Externí odkaz:
https://doaj.org/article/22978372a9134263a1f17e8fa4cfa4d9
Autor:
Dominik Awad, Michael Prattes, Lisa Kofler, Ingrid Rössler, Mathias Loibl, Melanie Pertl, Gertrude Zisser, Heimo Wolinski, Brigitte Pertschy, Helmut Bergler
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-16 (2019)
Abstract Background Ribosome biogenesis is a central process in every growing cell. In eukaryotes, it requires more than 250 non-ribosomal assembly factors, most of which are essential. Despite this large repertoire of potential targets, only very fe
Externí odkaz:
https://doaj.org/article/eb6ec7c70eda484b842720925e25f15a
Autor:
Thomas L. Pulliam, Dominik Awad, Jenny J. Han, Mollianne M. Murray, Jeffrey J. Ackroyd, Pavithr Goli, Jonathan S. Oakhill, John W. Scott, Michael M. Ittmann, Daniel E. Frigo
Publikováno v:
Cells, Vol 11, Iss 12, p 1890 (2022)
Despite early studies linking calcium-calmodulin protein kinase kinase 2 (CAMKK2) to prostate cancer cell migration and invasion, the role of CAMKK2 in metastasis in vivo remains unclear. Moreover, while CAMKK2 is known to regulate systemic metabolis
Externí odkaz:
https://doaj.org/article/dc59b8044ecb48d8896b850966d1a71a
Autor:
Thomas L. Pulliam, Pavithr Goli, Dominik Awad, Chenchu Lin, Sandi R. Wilkenfeld, Daniel E. Frigo
Publikováno v:
Nature Reviews Urology. 19:367-380
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cd90795d9305673e06d19e154062e20
https://doi.org/10.1038/s41585-022-00588-z
https://doi.org/10.1038/s41585-022-00588-z
Autor:
Dominik Awad, Thomas L. Pulliam, Meredith Spradlin, Pham Hong-Anh Cao, Elavarasan Subramani, Tristen V. Tellman, Caroline F. Ribeiro, Hubert Pakula, Jeffrey J. Ackroyd, Mollianne M. Murray, Jenny J. Han, Badrajee Piyarathna, Justin M. Drake, Michael M. Ittmann, Cristian Coarfa, Mary C. Farach-Carson, Massimo Loda, Livia S. Eberlin, Daniel E. Frigo
SummaryLipid metabolism plays a central role in prostate cancer. To date, the major focus on prostate cancer lipid metabolism has centered onde novolipogenesis and lipid uptake with little consideration for how cancer cells access these lipids once t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e86730db8380faa6251dbcc590f0e44
https://doi.org/10.1101/2022.11.02.514910
https://doi.org/10.1101/2022.11.02.514910
Autor:
Thomas L, Pulliam, Dominik, Awad, Jenny J, Han, Mollianne M, Murray, Jeffrey J, Ackroyd, Pavithr, Goli, Jonathan S, Oakhill, John W, Scott, Michael M, Ittmann, Daniel E, Frigo
Publikováno v:
Cells. 11(12)
Despite early studies linking calcium-calmodulin protein kinase kinase 2 (CAMKK2) to prostate cancer cell migration and invasion, the role of CAMKK2 in metastasis in vivo remains unclear. Moreover, while CAMKK2 is known to regulate systemic metabolis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5817c09091fbc5ed3ad677af4364557c
https://pubmed.ncbi.nlm.nih.gov/35741020
https://pubmed.ncbi.nlm.nih.gov/35741020
Autor:
William J. Zuercher, Christopher G. Langendorf, Rafael M. Couñago, Chenchu Lin, Alfredo Picado, Mohammad Anwar Hossain, Jonathan S. Oakhill, Dominik Awad, Joseph R. Pilotte, David H. Drewry, Carolina M. C. Catta-Preta, Daniel E. Frigo, Carrow I. Wells, P.Z. Ramos, Christopher R. M. Asquith, Sean N. O’Byrne, Timothy M. Willson, Louisa Temme, A.S. Santiago, Kevin Nay, Thomas L. Pulliam, John W. Scott, Yi Liang, Benjamin J. Eduful
Publikováno v:
Journal of Medicinal Chemistry
CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation is linked with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to probe CAMKK2 signaling, has limitations. To identify promising scaffolds as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbcff8ed683ad253b52fbd8a7704dcb
https://acuresearchbank.acu.edu.au/item/8x148/hinge-binder-scaffold-hopping-identifies-potent-calcium-calmodulin-dependent-protein-kinase-kinase-2-camkk2-inhibitor-chemotypes
https://acuresearchbank.acu.edu.au/item/8x148/hinge-binder-scaffold-hopping-identifies-potent-calcium-calmodulin-dependent-protein-kinase-kinase-2-camkk2-inhibitor-chemotypes
Autor:
Chenchu Lin, David H. Drewry, Carrow I. Wells, Joseph R. Pilotte, John W. Scott, Benjamin J. Eduful, Yi Liang, Rafael M. Couñago, Carolina M. C. Catta-Preta, Alfredo Picado, Sean N. O’Byrne, Jonathan S. Oakhill, Dominik Awad, Christopher G. Langendorf, Christopher R. M. Asquith, Timothy M. Willson, Thomas L. Pulliam, Louisa Temme, Daniel E. Frigo, William J. Zuercher, P.Z. Ramos, A.S. Santiago, Kevin Nay
CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation is linked with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to probe CAMKK2 signaling, has limitations. To identify promising scaffolds as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103f4b3c66ec89afbef05608bfa9d132
https://doi.org/10.26434/chemrxiv.13484763
https://doi.org/10.26434/chemrxiv.13484763
Autor:
Dominik Awad, Christian González-Rivera, Peter J. Christie, Yang Grace Li, Pratick Khara, Maxim Bogisch, Roosheel S. Patel
Publikováno v:
Molecular Microbiology. 111:96-117
Mobile genetic elements (MGEs) encode type IV secretion systems (T4SSs) known as conjugation machines for their transmission between bacterial cells. Conjugation machines are composed of an envelope-spanning translocation channel, and those functioni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d01f4e4f9301dbdb43744f9764776a6
https://doi.org/10.1111/mmi.14141
https://doi.org/10.1111/mmi.14141