Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Dominik A Nahotko"'
Autor:
Ernst Lengyel, Marc Ferrer, Juan Marugan, Kyle R. Brimacombe, Yen-Ju Chen, Chun-Yi Chiang, Siquan Chen, Sarah Fazal, Kristen Wroblewski, Dominik A. Nahotko, Betul Kara, Min Shen, Madhu Lal-Nag, Hilary A. Kenny
Supplementary Figure S4 shows the activity of non-lead compounds in secondary biological assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa4da14d7c7e052f7a053a7c7a1cad7
https://doi.org/10.1158/1535-7163.22506267.v1
https://doi.org/10.1158/1535-7163.22506267.v1
Autor:
Ernst Lengyel, Marc Ferrer, Juan Marugan, Kyle R. Brimacombe, Yen-Ju Chen, Chun-Yi Chiang, Siquan Chen, Sarah Fazal, Kristen Wroblewski, Dominik A. Nahotko, Betul Kara, Min Shen, Madhu Lal-Nag, Hilary A. Kenny
Supplementary Figure S1 shows the primary screen, protocol, layout and performance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d8be9448fdbdd4b7d01233408e4c4b
https://doi.org/10.1158/1535-7163.22506276.v1
https://doi.org/10.1158/1535-7163.22506276.v1
Autor:
Ernst Lengyel, Marc Ferrer, Juan Marugan, Kyle R. Brimacombe, Yen-Ju Chen, Chun-Yi Chiang, Siquan Chen, Sarah Fazal, Kristen Wroblewski, Dominik A. Nahotko, Betul Kara, Min Shen, Madhu Lal-Nag, Hilary A. Kenny
Supplementary Figure S7 shows the effect of Milciclib and NCGC00117362 on mTOR, and PP-121 and NCGC00117362 on retinoblastoma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0dbd9ce6018ac009542c848f97ad0a
https://doi.org/10.1158/1535-7163.22506258
https://doi.org/10.1158/1535-7163.22506258
Autor:
Ernst Lengyel, Marc Ferrer, Juan Marugan, Kyle R. Brimacombe, Yen-Ju Chen, Chun-Yi Chiang, Siquan Chen, Sarah Fazal, Kristen Wroblewski, Dominik A. Nahotko, Betul Kara, Min Shen, Madhu Lal-Nag, Hilary A. Kenny
Supplementary Table S1 shows the gene and pathway analysis of genes regulated by NCGC00117362 in Kuramochi ovarian cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a687cc6a0b21cdc3190fc004856e02
https://doi.org/10.1158/1535-7163.22506243
https://doi.org/10.1158/1535-7163.22506243
Autor:
Ernst Lengyel, Marc Ferrer, Juan Marugan, Kyle R. Brimacombe, Yen-Ju Chen, Chun-Yi Chiang, Siquan Chen, Sarah Fazal, Kristen Wroblewski, Dominik A. Nahotko, Betul Kara, Min Shen, Madhu Lal-Nag, Hilary A. Kenny
The tumor microenvironment (TME) is a key determinant of metastatic efficiency. We performed a quantitative high-throughput screen (qHTS) of diverse medicinal chemistry tractable scaffolds (44,420 compounds) and pharmacologically active small molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e72eab370c62166cd7e7a4b4c63489d
https://doi.org/10.1158/1535-7163.c.6538335
https://doi.org/10.1158/1535-7163.c.6538335
Autor:
Ernst Lengyel, Marc Ferrer, Juan Marugan, Kyle R. Brimacombe, Yen-Ju Chen, Chun-Yi Chiang, Siquan Chen, Sarah Fazal, Kristen Wroblewski, Dominik A. Nahotko, Betul Kara, Min Shen, Madhu Lal-Nag, Hilary A. Kenny
Supplementary Methods describes the Proteomics and Gene Expression Analysis Methods and References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784ddf962fccbfa132187f45dfcd6358
https://doi.org/10.1158/1535-7163.22506246.v1
https://doi.org/10.1158/1535-7163.22506246.v1
Autor:
Ernst Lengyel, Marc Ferrer, Juan Marugan, Kyle R. Brimacombe, Yen-Ju Chen, Chun-Yi Chiang, Siquan Chen, Sarah Fazal, Kristen Wroblewski, Dominik A. Nahotko, Betul Kara, Min Shen, Madhu Lal-Nag, Hilary A. Kenny
Supplementary Figure S9 shows the testing of SAR analogs of NCGC00117362 in secondary confirmatory assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a15e911a7fcd81c44a0982b5b43cc1d
https://doi.org/10.1158/1535-7163.22506252.v1
https://doi.org/10.1158/1535-7163.22506252.v1
Autor:
Ernst Lengyel, Marc Ferrer, Juan Marugan, Kyle R. Brimacombe, Yen-Ju Chen, Chun-Yi Chiang, Siquan Chen, Sarah Fazal, Kristen Wroblewski, Dominik A. Nahotko, Betul Kara, Min Shen, Madhu Lal-Nag, Hilary A. Kenny
Supplementary Figure S2 shows the activity outcomes from confirmatory and counter screens.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c868577e01d7b85a44b66234d1e03af
https://doi.org/10.1158/1535-7163.22506273
https://doi.org/10.1158/1535-7163.22506273
Autor:
Ernst Lengyel, Marc Ferrer, Juan Marugan, Kyle R. Brimacombe, Yen-Ju Chen, Chun-Yi Chiang, Siquan Chen, Sarah Fazal, Kristen Wroblewski, Dominik A. Nahotko, Betul Kara, Min Shen, Madhu Lal-Nag, Hilary A. Kenny
Supplementary Figure S8 shows the validation of gene regulation by NCGC00117362 in ovarian cancer cell lines and effect of PP-121 and Milciclib on these genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0a82efb062565c6070520a36cc4c0e
https://doi.org/10.1158/1535-7163.22506255.v1
https://doi.org/10.1158/1535-7163.22506255.v1
Autor:
Ernst Lengyel, Marc Ferrer, Juan Marugan, Kyle R. Brimacombe, Yen-Ju Chen, Chun-Yi Chiang, Siquan Chen, Sarah Fazal, Kristen Wroblewski, Dominik A. Nahotko, Betul Kara, Min Shen, Madhu Lal-Nag, Hilary A. Kenny
Supplementary Figure S5 shows the activity of inert compounds and mTOR inhibitors in secondary biological in vivo adhesion/invasion assay.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1cff45ddd8a3588c33f68206597ce63
https://doi.org/10.1158/1535-7163.22506264
https://doi.org/10.1158/1535-7163.22506264