An integrated organoid omics map extends modeling potential of kidney disease

Autor: Moritz Lassé, Jamal El Saghir, Celine C. Berthier, Sean Eddy, Matthew Fischer, Sandra D. Laufer, Dominik Kylies, Arvid Hutzfeldt, Léna Lydie Bonin, Bernhard Dumoulin, Rajasree Menon, Virginia Vega-Warner, Felix Eichinger, Fadhl Alakwaa, Damian Fermin, Anja M. Billing, Akihiro Minakawa, Phillip J. McCown, Michael P. Rose, Bradley Godfrey, Elisabeth Meister, Thorsten Wiech, Mercedes Noriega, Maria Chrysopoulou, Paul Brandts, Wenjun Ju, Linda Reinhard, Elion Hoxha, Florian Grahammer, Maja T. Lindenmeyer, Tobias B. Huber, Hartmut Schlüter, Steffen Thiel, Laura H. Mariani, Victor G. Puelles, Fabian Braun, Matthias Kretzler, Fatih Demir, Jennifer L. Harder, Markus M. Rinschen

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Abstract Kidney organoids are a promising model to study kidney disease, but their use is constrained by limited knowledge of their functional protein expression profile. Here, we define the organoid proteome and transcriptome trajectories over cultu

Externí odkaz: https://doaj.org/article/39ed8a12de7946c9bcf28c0777cf6607

Improvement of renal function after transcatheter aortic valve replacement and its impact on survival

Autor: Dominik Kylies, Sandra Freitag-Wolf, Florian Fulisch, Hatim Seoudy, Christian Kuhn, Lars Philipp Kihm, Thomas Pühler, Georg Lutter, Astrid Dempfle, Norbert Frey, Thorsten Feldkamp, Derk Frank

Publikováno v: BMC Nephrology, Vol 22, Iss 1, Pp 1-9 (2021)

Abstract Background Chronic kidney disease as well as acute kidney injury are associated with adverse outcomes after transcatheter aortic valve replacement (TAVR). However, little is known about the prognostic implications of an improvement in renal

Externí odkaz: https://doaj.org/article/44791d70c8994010ac9a9dc276ab3e5b

Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Autor: Joseph Tintelnot, Yang Xu, Till R. Lesker, Martin Schönlein, Leonie Konczalla, Anastasios D. Giannou, Penelope Pelczar, Dominik Kylies, Victor G. Puelles, Agata A. Bielecka, Manuela Peschka, Filippo Cortesi, Kristoffer Riecken, Maximilian Jung, Lena Amend, Tobias S. Bröring, Marija Trajkovic-Arsic, Jens T. Siveke, Thomas Renné, Danmei Zhang, Stefan Boeck, Till Strowig, Faik G. Uzunoglu, Cenap Güngör, Alexander Stein, Jakob R. Izbicki, Carsten Bokemeyer, Marianne Sinn, Alec C. Kimmelman, Samuel Huber, Nicola Gagliani

Publikováno v: Tintelnot, J, Xu, Y, Lesker, T R, Schönlein, M, Konczalla, L, Giannou, A D, Pelczar, P, Kylies, D, Puelles, V G, Bielecka, A A, Peschka, M, Cortesi, F, Riecken, K, Jung, M, Amend, L, Bröring, T S, Trajkovic-Arsic, M, Siveke, J T, Renné, T, Zhang, D, Boeck, S, Strowig, T, Uzunoglu, F G, Güngör, C, Stein, A, Izbicki, J R, Bokemeyer, C, Sinn, M, Kimmelman, A C, Huber, S & Gagliani, N 2023, ' Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer ', Nature, vol. 615, no. 7950, pp. 168-174 . https://doi.org/10.1038/s41586-023-05728-y

Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second most deadly cancer by 2040, owing to the high incidence of metastatic disease and limited responses to treatment1,2. Less than half of all patients respond to the primary treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6958462eedf5593c667bb2b17214d3f0
https://doi.org/10.1038/s41586-023-05728-y

The Amphiregulin/EGFR axis protects from lupus nephritis via downregulation of pathogenic CD4

Autor: Simon, Melderis, Matthias T, Warkotsch, Julien, Dang, Julia, Hagenstein, Laura-Isabell, Ehnold, Georg R, Herrnstadt, Christoph B, Niehus, Frederic C, Feindt, Dominik, Kylies, Victor G, Puelles, Carmen, Berasain, Matias A, Avila, Katrin, Neumann, Gisa, Tiegs, Tobias B, Huber, Pierre-Louis, Tharaux, Oliver M, Steinmetz

Publikováno v: Journal of autoimmunity. 129

Systemic lupus erythematosus (SLE) is a common autoimmune disorder with a complex and poorly understood immuno-pathogenesis. Lupus nephritis (LN) is a frequent and difficult to treat complication, which causes high morbidity and mortality. The multif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bf41c1ab010538e4f23762b31ee22de8
https://pubmed.ncbi.nlm.nih.gov/35468361

Clonal expansion and activation of tissue-resident memory-like T H 17 cells expressing GM-CSF in the lungs of patients with severe COVID-19

Autor: Francesco Siracusa, Ansgar W. Lohse, Dominik Kylies, Filippo Cortesi, Yu Zhao, Mascha Binder, Nicola Gagliani, Susanne Pfefferle, Milagros N. Wong, Victor G. Puelles, Marissa Herrmann, Lidia Bosurgi, Christoph Schultheiß, Leon U. B. Enk, Patricia Bartsch, Stefan Bonn, Malte Hellmig, Ulf Panzer, Kevin Roedl, Dominik Jarczak, Elisa Rosati, Samuel Huber, Petra Bacher, Jan-Eric Turner, Christoph Kilian, Christian Krebs, Jan-Peter Sperhake, Ann-Christin Gnirck, Marc Lütgehetmann, Julian Schulze Zur-Wiesch, Stefan Steurer, Alina Borchers, Nicola Scheibel, Stefan Kluge, Marylyn M. Addo, Hans-Joachim Paust, Tobias B. Huber, Fabian Hausmann

Publikováno v: Science Immunology. 6

Hyperinflammation contributes to lung injury and subsequent acute respiratory distress syndrome (ARDS) with high mortality in patients with severe coronavirus disease 2019 (COVID-19). To understand the underlying mechanisms involved in lung pathology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4a5ccddc6a55c72f86683a58fce8cc
https://doi.org/10.1126/sciimmunol.abf6692