Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Dominick DelGrande"'
Autor:
Paivi Jaana Kukkola, Suraj S. Shetty, Natalie A. Bilci, Paula Savage, Theodore Ikler, Arco Y. Jeng, Dominick DelGrande
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1737-1740
1,3-Disubstituted isoindolines have been discovered as a new class of potent functional ET A selective receptor antagonists through pharmacophore analysis of existing nonpeptide endothelin antagonists. The structure–activity relationships for both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6e1f77d9a18d7b3a45f6a318e01761
https://doi.org/10.1016/s0960-894x(01)00273-6
https://doi.org/10.1016/s0960-894x(01)00273-6
Autor:
Gary M. Coppola, Xilin Liu, Robert C. Anderson, Douglas C. Knorr, William S. Fillers, James L. Stanton, Jiaping Gao, Tomaselli Hc, Christine C. Vinluan, Thomas Daniel Aicher, Carol J. Dragland, Suraj S. Shetty, Wieslawa Maniara, A. Islam, Emma L. Kaplan, William R. Mann, Leonard J. Brand, Donald Mark Sperbeck, R. E. Walter, Dominick DelGrande, R. J. Lozito
Publikováno v:
Journal of Medicinal Chemistry. 43:236-249
N‘-Methyl-N-(4-tert-butyl-1,2,5,6-tetrahydropyridine)thiourea, SDZ048-619 (1), is a modest inhibitor (IC50 = 180 μM) of pyruvate dehydrogenase kinase (PDHK). In an optimization of the N-methylcarbothioamide moiety of 1, it was discovered that amid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a21921472d2095e7c5eea09d6d92805
https://doi.org/10.1021/jm990358+
https://doi.org/10.1021/jm990358+
Autor:
Emma L. Kaplan, Gary M. Coppola, Xilin Liu, Gregory Raymond Bebernitz, Donald Mark Sperbeck, Dominick DelGrande, Wieslawa Maniara, Leonard J. Brand, Suraj S. Shetty, Thomas Daniel Aicher, Robert C. Anderson, Charles F. Jewell, R. J. Lozito, Douglas C. Knorr, A. Islam, Chen Liu, Christine C. Vinluan, Jianping Gao, Robert J. Strohschein, William R. Mann, Carol J. Dragland, R. E. Walter
Publikováno v:
Journal of Medicinal Chemistry. 42:2741-2746
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80d109ec966714cd20d37ebc973dd61
https://doi.org/10.1021/jm9902584
https://doi.org/10.1021/jm9902584
Publikováno v:
Biochemical and Biophysical Research Communications. 191:459-464
IRL 1620 (Suc-[Glu9,Ala11,15]-ET-1 (8-21)) (0.1 nM - 1 microM), a novel ETB-selective endothelin (ET) agonist, produced endothelium-dependent relaxations in precontracted rabbit mesenteric artery (2 nM, EC50) and endothelium-independent contractions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1c4e6380f08788fc665024bb802cf3
https://doi.org/10.1006/bbrc.1993.1240
https://doi.org/10.1006/bbrc.1993.1240
Autor:
Arco Y. Jeng, Dominick DelGrande, Natalie A. Bilci, Paula Savage, Paivi Jaana Kukkola, Suraj S. Shetty, Theodore Ikler
Publikováno v:
ChemInform. 32
1,3-Disubstituted isoindolines have been discovered as a new class of potent functional ET A selective receptor antagonists through pharmacophore analysis of existing nonpeptide endothelin antagonists. The structure–activity relationships for both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c242b0772da276445eea28df4233ef0d
https://doi.org/10.1002/chin.200147099
https://doi.org/10.1002/chin.200147099
Autor:
Wei H. Wang, Christine C. Vinluan, Robert J. Strohschein, Xilin Liu, Emma L. Kaplan, Dominick DelGrande, Gregory Raymond Bebernitz, Douglas C. Knorr, Jennifer Tan, Jiaping Gao, Suraj S. Shetty, James L. Stanton, Charles Liu, Thomas Daniel Aicher, Carol J. Dragland, William R. Mann, Leonard J. Brand, Robert J. Lozito, Wieslawa Maniara, Amin Islam
Publikováno v:
Journal of medicinal chemistry. 43(11)
The optimization of a series of anilide derivatives of (R)-3,3, 3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase (PDHK) is described that started from N-phenyl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9230c1ef002859de18c4f7fe1f8ef950
https://pubmed.ncbi.nlm.nih.gov/10841803
https://pubmed.ncbi.nlm.nih.gov/10841803
Autor:
Shiling Hu, Joseph L. Balwierczak, Dominick DelGrande, Helen S. Kim, Christine M. Krulan, George B. Weiss
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 352(2)
The rank order of potency of a series of benzopyran and cyanoguanidine K+ channel openers (KCOs) for causing relaxation of the PGF2 alpha-precontracted porcine coronary artery was determined. Glyburide, an inhibitor of KATP channels, showed an appare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fef2bf1a0c36ae8fc70350cacbbb0c
https://pubmed.ncbi.nlm.nih.gov/7477446
https://pubmed.ncbi.nlm.nih.gov/7477446
Publikováno v:
Journal of biochemistry. 112(1)
Endothelin-1 (ET-1) is a potent peptidic vasoconstrictor. This peptide has been shown to be cleared rapidly by the kidney. The purpose of the present study was to assess the involvement of renal proteolytic enzymes in the clearance/degradation of ET-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5f20e705aca21de38d8d2ddf6e7515
https://pubmed.ncbi.nlm.nih.gov/1429507
https://pubmed.ncbi.nlm.nih.gov/1429507
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