Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Dominick Anthony Quagliato"'
Autor:
Steve Jacobsen, Peter H. Reinhart, Albert J. Robichaud, William Ronald Solvibile, Michael S. Malamas, Jim Turner, Koi Michele Morris, Andrea Olland, Ping Zhou, Kristi Fan, Jim Erdei, Menelas N. Pangalos, David Riddell, Dominick Anthony Quagliato, Erik Wagner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6597-6605
The identification of small molecule aminohydantoins as potent and selective human β-secretase inhibitors is reported. These analogs exhibit good brain permeability (40-70%), low nanomolar potency for BACE1, and demonstrate >100-fold selectivity for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17719aeaede49b88c03aa1d414605290
https://doi.org/10.1016/j.bmcl.2010.09.029
https://doi.org/10.1016/j.bmcl.2010.09.029
Autor:
Betsy L. Joslyn, A. Wojdan, Paul Jeffrey Dollings, Terrence M. Dolak, David D. Deininger, Mary Ellen Morin, Richard M. Soll, Dominick Anthony Quagliato, Chris Bohan, George Oshiro, Sung J. Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 1:591-594
A series of benzopyran-related potassium channel activators were prepared and evaluated at the calculated ED 30 dose in the spontaneously hypertensive rat. The duration of the blood pressure lowering effect was found to be related to the lipophilicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84bf3d8f94803de94419b6fad768427c
https://doi.org/10.1016/s0960-894x(01)81157-4
https://doi.org/10.1016/s0960-894x(01)81157-4
Autor:
Chiacheng Shaw, Eric N.C. Browne, Dominick Anthony Quagliato, Richard M. Soll, Leslie G. Humber, Donna Van Engen, Betsy L. Joslyn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 1:39-42
The synthesis of the antihypertensive potassium channel activator WAY-120,491 (1) is described. X-ray crystallographic analysis of carbamate 15a established the 3S,4R configuration of 1. The large scale classical resolution of racemic 9 was facilitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c7915265a199e43a8269229c0b90f51
https://doi.org/10.1016/s0960-894x(01)81086-6
https://doi.org/10.1016/s0960-894x(01)81086-6
Autor:
Kristine Svenson, Youjun Yang, Dominick Anthony Quagliato, Shaughnessy M. Naughton, Guy Singh, Beth A. Rasmussen, Claudia Smeltzer, Tarek S. Mansour, Joel Bard, Girija Krishnamurthy, Schuyler Adam Antane, Peter Petersen, Koi Michele Morris, Rajiv Chopra, Anatoly Severin, Craig E. Caufield
Publikováno v:
ChemMedChem. 2(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53361d0de2b042c5d0e3842b984da14
https://pubmed.ncbi.nlm.nih.gov/17600795
https://pubmed.ncbi.nlm.nih.gov/17600795
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b883b65a185cb5a1788bee222bdc486
https://doi.org/10.1002/chin.200049027
https://doi.org/10.1002/chin.200049027
Publikováno v:
The Journal of organic chemistry. 65(16)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0548a433d21aa7616dc1775a7f5ad204
https://pubmed.ncbi.nlm.nih.gov/10956492
https://pubmed.ncbi.nlm.nih.gov/10956492
Autor:
Thomas M. Argentieri, D. Herbst, Geraldine Ruth Mcfarlane, N W Norton, Russell F. Graceffa, Chris Freeden, Dawn Warga, Jeffrey H. Sheldon, Joseph R. Lennox, A. Wojdan, Madelene Antane, G. D. Francisco, John A. Butera, Hirth Bradford Hammond, Adam M. Gilbert, Eric Gould Gundersen, Morgan Woods, Dominick Anthony Quagliato
Publikováno v:
Journal of medicinal chemistry. 43(6)
A novel series of benzylamine, potassium channel openers (KCOs) is presented as part of our program toward designing new, bladder-selective compounds for the treatment of urge urinary incontinence (UUI). We have found that the in vitro potency of (R)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe3c6987f3ee897709ddf1f0ebb8a8c
https://pubmed.ncbi.nlm.nih.gov/10737753
https://pubmed.ncbi.nlm.nih.gov/10737753
Autor:
Edward Martin Matelan, Russell F. Graceffa, Dawn Warga, Morgan Woods, Thomas M. Argentieri, Madelene Antane, John A. Butera, Walter Spinelli, Joseph R. Lennox, N. Wesley Norton, Dominick Anthony Quagliato, Hirth Bradford Hammond, Chris Freeden, and Alexandra Wojdan, Jeffrey H. Sheldon, Schuyler Adam Antane, Douglas John Jenkins
Publikováno v:
Journal of medicinal chemistry. 43(6)
A structurally novel series of adenosine 5'-triphosphate-sensitive potassium (K(ATP)) channel openers is described. As part of our efforts directed toward identifying novel, bladder-selective potassium channel openers (KCOs) targeted for urge urinary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deda2c64afdeddc908af1327f8b7dc56
https://pubmed.ncbi.nlm.nih.gov/10737752
https://pubmed.ncbi.nlm.nih.gov/10737752
Publikováno v:
The Journal of Organic Chemistry. 50:1621-1626
Le trimethylsilyl-1 phenylthio-1 ethylene reagit avec les chlorures d'acyle cycliques α, β insatures pour donner des β-mercaptophenylcyclopentenones. La reaction a ete appliquee a la synthese de l'hirsutene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49cfa013bb5fb960c69cf821aca65c27
https://doi.org/10.1021/jo00210a013
https://doi.org/10.1021/jo00210a013