Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Dominica Willmann"'
Autor:
Sheng Wang, Sebastian O. Klein, Sylvia Urban, Maximilian Staudt, Nicolas P. F. Barthes, Dominica Willmann, Johannes Bacher, Manuela Sum, Helena Bauer, Ling Peng, Georg A. Rennar, Christian Gratzke, Katrin M. Schüle, Lin Zhang, Oliver Einsle, Holger Greschik, Calum MacLeod, Christopher G. Thomson, Manfred Jung, Eric Metzger, Roland Schüle
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Inhibition of epigenetic regulators by small molecules is an attractive strategy for cancer treatment. Recently, we characterised the role of lysine methyltransferase 9 (KMT9) in prostate, lung, and colon cancer. Our observation that the enz
Externí odkaz:
https://doaj.org/article/dd0315952e94463cb2a9a88ac996f944
Autor:
Milica Tosic, Anita Allen, Dominica Willmann, Christoph Lepper, Johnny Kim, Delphine Duteil, Roland Schüle
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Satellite cells can differentiate both into myocytes and brown adipocytes. Here, the authors show that the histone demethylase Lsd1 prevents adipogenic differentiation of satellite cells by repressing expression of Glis1, and that its ablation change
Externí odkaz:
https://doaj.org/article/3468bea8b20d48ef8bf865d12864b2d3
Autor:
Delphine Duteil, Milica Tosic, Franziska Lausecker, Hatice Z. Nenseth, Judith M. Müller, Sylvia Urban, Dominica Willmann, Kerstin Petroll, Nadia Messaddeq, Laura Arrigoni, Thomas Manke, Jan-Wilhelm Kornfeld, Jens C. Brüning, Vyacheslav Zagoriy, Michael Meret, Jörn Dengjel, Toufike Kanouni, Roland Schüle
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 1008-1021 (2016)
Previous work indicated that lysine-specific demethylase 1 (Lsd1) can positively regulate the oxidative and thermogenic capacities of white and beige adipocytes. Here we investigate the role of Lsd1 in brown adipose tissue (BAT) and find that BAT-sel
Externí odkaz:
https://doaj.org/article/15acdfef4129450fb67865a1bd83d169
Autor:
Roland Schüle, Jochen Maurer, Toufike Kanouni, Jeffrey A. Stafford, Michael B. Wallace, Jiangchun Xu, Elmar Stickeler, Melanie Boerries, Marie Follo, Amelie Proske, Peter Bronsert, Nicola Iovino, Fides Zenk, Anita Allen, Dominica Willmann, Sylvia Urban, Bogdan-Tiberius Preca, Juliane Strietz, Stella S. Stepputtis, Eric Metzger
This file contains the legends to all Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5761318b1f6435dcbf3e792e5a2fa818
https://doi.org/10.1158/0008-5472.22419060.v1
https://doi.org/10.1158/0008-5472.22419060.v1
Autor:
Roland Schüle, Jochen Maurer, Toufike Kanouni, Jeffrey A. Stafford, Michael B. Wallace, Jiangchun Xu, Elmar Stickeler, Melanie Boerries, Marie Follo, Amelie Proske, Peter Bronsert, Nicola Iovino, Fides Zenk, Anita Allen, Dominica Willmann, Sylvia Urban, Bogdan-Tiberius Preca, Juliane Strietz, Stella S. Stepputtis, Eric Metzger
H3K9me3 levels increase upon treatment with QC6352. Changes in H3K9me3 levels are depicted according to genomic location.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03971b883243e51d248ae86c72123875
https://doi.org/10.1158/0008-5472.22419069
https://doi.org/10.1158/0008-5472.22419069
Autor:
Roland Schüle, Eric Metzger, Rebecca Kesselring, Stefan Fichtner-Feigl, Florian R. Greten, Valentina Petrocelli, Mark Schmitt, Karsten Rippe, Lisa Marx, Stephan M. Tirier, Sylvia Urban, Dominica Willmann, Félicie Cottard, Christopher Berlin
File with all the Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a9cf8a88342f87eb3f53092e1c8605
https://doi.org/10.1158/0008-5472.22430692
https://doi.org/10.1158/0008-5472.22430692
Autor:
Roland Schüle, Eric Metzger, Rebecca Kesselring, Stefan Fichtner-Feigl, Florian R. Greten, Valentina Petrocelli, Mark Schmitt, Karsten Rippe, Lisa Marx, Stephan M. Tirier, Sylvia Urban, Dominica Willmann, Félicie Cottard, Christopher Berlin
Colorectal cancer is among the leading causes of cancer-associated deaths worldwide. Treatment failure and tumor recurrence due to survival of therapy-resistant cancer stem/initiating cells represent major clinical issues to overcome. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48d5c76e37676e1e58da97cf971dc2e8
https://doi.org/10.1158/0008-5472.c.6513688.v1
https://doi.org/10.1158/0008-5472.c.6513688.v1
Autor:
Roland Schüle, Eric Metzger, Rebecca Kesselring, Stefan Fichtner-Feigl, Florian R. Greten, Valentina Petrocelli, Mark Schmitt, Karsten Rippe, Lisa Marx, Stephan M. Tirier, Sylvia Urban, Dominica Willmann, Félicie Cottard, Christopher Berlin
File with all the Supplementary Tables (Supplementary Tables S1-S3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60306b50fa407b0ac15144745c072364
https://doi.org/10.1158/0008-5472.22430689.v1
https://doi.org/10.1158/0008-5472.22430689.v1
Autor:
Roland Schüle, Jochen Maurer, Toufike Kanouni, Jeffrey A. Stafford, Michael B. Wallace, Jiangchun Xu, Elmar Stickeler, Melanie Boerries, Marie Follo, Amelie Proske, Peter Bronsert, Nicola Iovino, Fides Zenk, Anita Allen, Dominica Willmann, Sylvia Urban, Bogdan-Tiberius Preca, Juliane Strietz, Stella S. Stepputtis, Eric Metzger
Traditional treatments for breast cancer fail to address therapy-resistant cancer stem–like cells that have been characterized by changes in epigenetic regulators such as the lysine demethylase KDM4. Here, we describe an orally available, selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::568147c1824ce1c828b615cb332bfec3
https://doi.org/10.1158/0008-5472.c.6510285.v1
https://doi.org/10.1158/0008-5472.c.6510285.v1
Autor:
Johannes Seitz, Marina Auth, Pavlos Tzortzoglou, Mirjam Hau, Johannes Schulz-Fincke, Dominica Willmann, Eric Metzger, Roland Schüle, Manfred Jung
Epigenetic modulators such as Lysine-specific Demethylase 1 (LSD1) and Histone Deacetylases (HDACs), are drug targets for cancer, neuropsychatric disease or inflammation but inhibitors of these enzymes exhibit considerable side effects. For a potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62d742a23d8f19e887f201859e8345d2
https://doi.org/10.26434/chemrxiv-2022-n11dq
https://doi.org/10.26434/chemrxiv-2022-n11dq